Antibiotic Resistance Profiles of Invasive Bacterial Isolates from Hospitalized Pediatric Patients in Serbia: A Multicenter Surveillance Study, 2020-2024 [0.03%]
塞尔维亚住院儿科患者侵袭性细菌分离株的抗生素耐药谱：一项多中心监测研究（2020-2024年）
Deana Medic,Dusan Mihajlo Spasic,Marija Kukuric et al.
Deana Medic et al.
Background: Antimicrobial resistance (AMR) threatens empirical therapy for invasive pediatric infections, but contemporary data from Serbia and the Western Balkans remain limited for blood and cerebrospinal fluid isolates. Methods: We perfo...
Ceftazidime-Avibactam as Early Empiric Therapy for Gram-Negative Nosocomial Infections: A Risk-Stratified Empiric Use Informed by National AMR Surveillance Data 2024 [0.03%]
碳青霉烯酶抑制剂头孢他啶-阿维巴坦作为早发性经验用药治疗院内获得性革兰阴性感染：基于全国抗微生物药物耐药监测数据分层的经验性用药策略（2024年）
Ahmad Subhi,Ruby Subhi,Yousef Sattar et al.
Ahmad Subhi et al.
Background: International evidence supports early initiation of ceftazidime-avibactam (CAZ-AVI) in carbapenem-resistant Enterobacterales (CRE) infections, with superior outcomes when therapy is initiated within 72 h. The ...
Field Evaluation of the ClaID PCR System Reveals Predominance of Clade I-Associated Molecular Profiles Among Clinical Candida auris Isolates Recovered in İstanbul, Türkiye [0.03%]
ClaID PCR系统现场评估揭示了临床分离株中Candida auris在伊斯坦布尔地区以Clade I关联分子谱系为主导
Feray Ferda Şenol,Zülal Aşçı Toraman,Uğur Vural et al.
Feray Ferda Şenol et al.
Background:Candida auris has emerged globally as a multidrug-resistant fungal pathogen responsible for healthcare-associated outbreaks and invasive infections. Whole-genome sequencing studies have demonstrated the existence of genetically d...
The Pharmacology of Bacterial Persistence: From Antibiotic Tolerance to Antimicrobial Resistance [0.03%]
细菌持留的药理学：从抗生素耐受性到抗菌药物抗性
Maria Cristina Caroleo,Maria Pisano,Erika Cione et al.
Maria Cristina Caroleo et al.
Background/Objectives: Persistent infections are characterized by recurrent treatment failure and relapse despite apparent antibiotic susceptibility by standard testing, a clinical reality not fully explained by conventional resistance para...
Use of Ceftazidime-Avibactam in a Late-Preterm Newborn with Multidrug-Resistant Enterobacter hormaechei Sepsis [0.03%]
新生儿期迟发性多重耐药恩不动杆菌血流感染使用头孢他啶-阿维巴坦治疗1例报告
Marcello Trizzino,Veronica Notarbartolo,Luca Pipitò et al.
Marcello Trizzino et al.
Background: Neonatal sepsis caused by multidrug-resistant (MDR) Gram-negative pathogens poses significant therapeutic challenges in neonatal intensive care units (NICUs), particularly in surgical neonates. Ceftazidime-avibactam (CAZ-AVI), a...
Outpatient Parenteral Antimicrobial Therapy in Asia: Evolution, Models, and Challenges over the Past Decade-A Narrative Review [0.03%]
亚洲十年来门诊抗菌治疗的发展、模式和挑战：叙述性回顾
Hsien-Po Huang,Po-Hsiu Huang,Wei-Hsuan Huang et al.
Hsien-Po Huang et al.
Background: Outpatient Parenteral Antimicrobial Therapy (OPAT) has long been established as a safe and cost-effective alternative to inpatient care in Western healthcare systems. In contrast, its implementation across Asia has historically ...
Antibiotic-Driven Gut Microbiome Dysbiosis: Resistome Dynamics, Metabolic Disruption, and Paths to Restoration [0.03%]
抗生素驱动的肠道微生物组失调：抗性基因库动态变化、代谢紊乱及恢复路径
Adelina-Gabriela Niculescu,Cristina-Maria Iacob,Elvira Brătilă et al.
Adelina-Gabriela Niculescu et al.
The gut microbiome is a dynamic ecosystem that plays essential roles in host metabolism, immune regulation, colonization resistance, and maintenance of intestinal homeostasis. Antibiotic exposure profoundly disrupts this ecosystem by reduci...
Solidagoic Acids L and M: Novel Antibacterial cis-Clerodane Diterpenoids Isolated from the Inflorescences of Solidago gigantea via a Bioassay-Guided Approach [0.03%]
通过生物测定指导从加拿大菊花中分离得到的新型抗菌顺式cleodane倍半萜类茋酸L和M
Márton Baglyas,Zoltán Bozsó,Ágnes M Móricz
Márton Baglyas
Background/Objectives: Plant secondary metabolites remain an invaluable source of novel antibacterial phytochemicals in the fight against antibiotic resistance. The medicinal plant Solidago gigantea Ait. (giant goldenrod) is an invasive spe...
Rivka F Kayser,Danielle Kamsan,Zvi G Loewy
Rivka F Kayser
Urinary tract infections (UTIs) are considered a significant public health issue due to their high incidence and prevalence, most notably among women. The potential for complications, including recurrent infections and antibiotic resistance...
Evaluation of Short Versus Long Course of Tobramycin Combined with Piperacillin/Tazobactam Against Antibiotic-Resistant Pseudomonas aeruginosa in a Hollow Fibre Infection Model [0.03%]
评估短程和长程托溴铵与哌拉西林他唑巴坦联合治疗抗药性铜绿假单胞菌的疗效：空纤维感染模型研究
Yalew M Wale,Jason A Roberts,Hayoung Won et al.
Yalew M Wale et al.
Aminoglycosides are commonly partnered with β-lactam antibiotics for empirical treatment of severe Gram-negative bacterial infections, including those caused by Pseudomonas aeruginosa. However, the optimal duration of aminoglycoside therap...