Outpatient Parenteral Antimicrobial Therapy in a Setting with High Prevalence of Multidrug Resistance: Challenges, Opportunities, and Stewardship Considerations [0.03%]
多重耐药高发背景下门诊抗菌药物静脉应用的挑战、机遇与使用管理考虑因素
Giacomo Ciusa,Giuseppe Pipitone,Bianca Catania et al.
Giacomo Ciusa et al.
Background: Outpatient parenteral antimicrobial therapy (OPAT) is increasingly used for complex infections, but data from settings with high prevalence of multidrug-resistant organisms (MDROs) are limited. Methods: We conducted a retrospect...
Sequence of Antibiotic Administration for the Treatment of Mycobacterium avium subsp. hominissuis Infection Might Influence the Response Outcome [0.03%]
克雷伯氏菌感染治疗中抗生素给药顺序可能会影响最终的治疗效果响应情况
Amy Leestemaker-Palmer,Stephanie Nuss,Luiz E Bermudez
Amy Leestemaker-Palmer
Background/objectives: Mycobacterium avium subsp. hominissuis is a cause of disseminated infections in immunosuppressed patients and pulmonary infections in individuals with chronic lung conditions. The treatment of this ...
Pharmacy-Led Digital Education for Rational Antibiotic Use in Companion Animals: A Randomized Controlled Trial [0.03%]
一种合理使用伴侣动物抗菌药物的药师主导的数字化教育模式：一项随机对照试验
Chanuttha Ploylearmsang,Chayanan Panmawong,Thanwarat Chinnachak et al.
Chanuttha Ploylearmsang et al.
Background: Inappropriate antibiotic use in companion animals contributes to antimicrobial resistance within the One Health context. Educational interventions targeting non-health companion animal owners, particularly undergraduate students...
Cooperative Oligomeric Peptide Combinations Enhance the Predicted Therapeutic Profile of SET-M33 [0.03%]
协同寡聚肽组合增强SET-M33的预期治疗作用
Ismael Castanon,Giovanni Cappello,Alessandro Rencinai et al.
Ismael Castanon et al.
Background/Objectives: Antimicrobial peptides (AMPs) are promising candidates against multidrug-resistant bacteria, although their clinical translation is frequently limited by cytotoxicity. In this study, we investigated whether combinatio...
Differential Regulation of Oxidative Burst by First Line Drugs Used Against Multi Drug-Resistant Tuberculosis in Naïve Human Innate Immune Cells [0.03%]
一线药物通过调控先天免疫细胞的氧化爆发抵抗耐多药结核病研究
Josephine Gal,Volda Gabro Stenback,Michaela Jonsson Nordvall et al.
Josephine Gal et al.
Background/Objectives: Reactive oxygen species (ROS) are key effectors of innate immunity but can also contribute to inflammation and tissue injury when their production is dysregulated. Although antibiotics are primarily selected for their...
Elongation Factor-G (fusA) Mutations That Confer Fusidic Acid Resistance in Staphylococcus haemolyticus [0.03%]
血红病葡萄球菌中赋予 fusidic 苄素抗性的 EF-G (fusA) 突变体
Cheng-Mao Ho,Lee-Chung Lin,Yu-Hsiang Ou et al.
Cheng-Mao Ho et al.
Background/Objectives:Staphylococcus haemolyticus is a common skin commensal that has emerged as a multidrug-resistant nosocomial pathogen, with sequence type 42 frequently implicated in clinical settings. The genetic basis of fusidic acid ...
Tracking Extended-Spectrum β-Lactamase-Producing Escherichia coli Across Human Communities and Dairy Ecosystems: A One Health Investigation [0.03%]
人社区和乳品生态系统之间的肠杆菌科Extended-spectrum β-内酰胺酶的传播：“同一健康”调查
Cassandra Klaas,Shawn Hoogstra,David Mahoney et al.
Cassandra Klaas et al.
Background: The rising prevalence of Extended-spectrum β-lactamase-producing (ESBL) Escherichia coli poses a significant threat to human and animal health. ...
National and Hospital Level Antimicrobial Consumption Patterns in Kenya [0.03%]
肯尼亚抗菌药物消耗的国家和医院水平的模式
Kizito M Mariita,Loice A Ombajo,Christine M Ngacha et al.
Kizito M Mariita et al.
Background: Robust antimicrobial consumption monitoring and correlation with antibiotic resistance trends is critical to informing evidence-based antimicrobial stewardship and is recommended by the World Health Organization Global Action Pl...
Antibiotic Prescribing Patterns for Pulpitis in Pediatric Dentistry: A Systematic Review and Meta-Analysis [0.03%]
儿科牙科中用于治疗牙髓炎的抗生素处方模式：系统评价和meta分析
Carmen Machuca-Portillo,Cira Suárez-Marchena,Lucy Chandler-Gutiérrez et al.
Carmen Machuca-Portillo et al.
Background: Pulpitis is a common cause of dental pain in children and is primarily an inflammatory condition that can be effectively managed with local operative treatment. Although antibiotics are indicated only in cases of systemic involv...
How Health Policies Shape Antibiotic Use: A Nationwide Study of "Access"-Group Antibiotics Availability and Consumption in a Middle-Income Country: The Case of Kazakhstan [0.03%]
抗生素使用受卫生政策影响的研究——以中等收入国家哈萨克斯坦的“获得”组抗生素可得性和使用情况全国性研究为例分析相关政策的影响：案例来自哈萨克斯坦
Antonio Sarria-Santamera,Márió Gajdács,Aliya Raimbayeva et al.
Antonio Sarria-Santamera et al.
Background/Objectives: Few studies have examined how health policies may influence antibiotic consumption at a global level, particularly with respect to the World Health Organization (WHO) "Access" group antibiotics. Our present study aims...