Impact of Light-Activated Nanocomposite with Erythrosine B on agr Quorum Sensing System in Staphylococcus aureus [0.03%]
光敏纳米复合材料激活剂 erythrosine B 对金黄色葡萄球菌agr群体感应系统的干扰作用
Larysa Bugyna,Ľubomír Švantner,Katarína Bilská et al.
Larysa Bugyna et al.
Backround: The agr (accessory gene regulator) quorum sensing (QS) system of Staphylococcus aureus participates significantly in its virulence and biofilm formation-either through its activation or suppression. The aim of ...
Establishing Priority Pediatric Antimicrobial Stewardship Interventions in the US: Findings from a Delphi Consensus Study [0.03%]
美国优先儿童抗菌药物管理干预措施的建立：德尔菲共识研究的结果
Harry Obeng,Emmanuel Tetteh,Sara Malone et al.
Harry Obeng et al.
Background/objectives: Antimicrobial resistance (AMR) is a major global health threat, with children at higher risk due to developmental differences in drug metabolism, limited treatment options and inappropriate antibiot...
The Potential for Sample Testing at the Pen Level to Inform Prudent Antimicrobial Selection for Bovine Respiratory Disease Treatment: Investigations Using a Feedlot Simulation Tool [0.03%]
基于饲料模拟工具的牛呼吸系统疾病治疗中以精确诊断为基础的抗菌药物选择的潜力评估：采样检测环节的重要作用
Dana E Ramsay,Wade McDonald,Sheryl P Gow et al.
Dana E Ramsay et al.
Background: Antimicrobial drugs are used to treat bacterial diseases in livestock production systems, including bovine respiratory disease (BRD) in feedlot cattle. It is recommended that therapeutic antimicrobial use (AMU) in food animals b...
Cerebrospinal Pharmacokinetic Modeling and Pharmacodynamic Simulation of High-Dose Cefazolin for Meningitis Caused by Methicillin-Susceptible Staphylococcus aureus [0.03%]
用于甲氧西林敏感金黄色葡萄球菌所致脑膜炎的高频塞唑匹钠的脑脊液药代动力学建模及药效学模拟研究
Tetsushu Onita,Kazuro Ikawa,Noriyuki Ishihara et al.
Tetsushu Onita et al.
Background: Cefazolin is being increasingly used to treat central nervous system infections caused by methicillin-susceptible Staphylococcus aureus (MSSA) to mitigate the side effects of existing anti-Staphylococcal drugs. This study aims t...
Imipenem/Relebactam Plus Aztreonam: First Reported Use in MDR Klebsiella pneumoniae Sternal Infection Complicated by Bacteremia [0.03%]
伊米培南/雷利巴坦联合亚胺培南治疗耐药克雷伯菌导致的复杂感染首例报告
Luca Pipitò,Raffaella Rubino,Rita Immordino et al.
Luca Pipitò et al.
Background: Carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a significant therapeutic challenge, particularly when multiple resistance mechanisms, such as metallo-β-lactamases (MBLs) and Klebsiella pneumoniae car...
In Silico Identification and Molecular Characterization of Lentilactobacillus hilgardii Antimicrobial Peptides with Activity Against Carbapenem-Resistant Acinetobacter baumannii [0.03%]
链格孢乳杆菌抗菌肽的计算机筛选及其分子特性分析——针对耐碳青霉烯类抗生素鲍曼不动杆菌的活性研究
Amanda Appel,Lily Velazco,Adit B Alreja et al.
Amanda Appel et al.
Background/objectives: Biofilm formation by Acinetobacter baumannii contributes to its persistence in clinical settings and resistance to antibiotic treatment. This study aims to identify and characterize antimicrobials f...
Impact of Antimicrobial-Resistant Bacterial Pneumonia on In-Hospital Mortality and Length of Hospital Stay: A Retrospective Cohort Study in Spain [0.03%]
一项西班牙回顾性队列研究：抗菌药物耐药细菌所致肺炎对住院死亡率和住院时间的影响
Iván Oterino-Moreira,Montserrat Pérez-Encinas,Francisco J Candel-González et al.
Iván Oterino-Moreira et al.
Objectives: Antimicrobial resistance is a major global health threat. This study aimed to assess the impact of antimicrobial-resistant bacterial pneumonia on in-hospital mortality and length of hospital stay in Spain usin...
Genomic Insights into an Environmental Vibrio parahaemolyticus Biofilm Isolate: Deciphering Alternative Resistance Mechanisms and Mobilizable Genetic Elements [0.03%]
海洋致病菌条件依赖型生物被膜形成机制及适应性遗传进化研究取得进展
Huiyu Liu,Yujian Dong,Zhongyang Lin et al.
Huiyu Liu et al.
Background/objectives: Biofilms are key in spreading antibiotic resistance in various ecosystems. This study employed comparative genomics to examine the resistance and adaptability mechanisms of the Vibrio parahaemolytic...
Bicarinalin Enhances the Antibacterial Activity of Levofloxacin and Clarithromycin Against Helicobacter pylori [0.03%]
bicarinalin增强左氧氟沙星和克拉霉素对幽门螺旋杆菌的抗菌活性
Iman Saleh,Pınar Küce Çevik
Iman Saleh
Background/Objectives:Helicobacter pylori (H. pylori) is a Gram-negative bacterium that colonizes the human stomach and causes various gastrointestinal diseases. Although antibiotic therapy is the most effective method for its eradication, ...
ICE Cle SHZ29: Novel Integrative and Conjugative Element (ICE)-Carrying Tigecycline Resistance Gene tet(X6) in Chryseobacterium lecithinasegens [0.03%]
新型整合与接合元件(ICE)携带者四环素耐药基因tet(X6)的Chryseobacterium lecithinasicum ICE Cle SHZ29
Xi Chen,Yifei Zhang,Chunling Jiang et al.
Xi Chen et al.
Background/Objectives: The global dissemination of tet(X) variants critically threatens tigecycline efficacy as a last-resort antibiotic. The aim of this study was to characterize a tet(X6)-carrying integrative and conjugative element (ICE)...