Márió Gajdács,Fernando Albericio
Márió Gajdács
The introduction of antibiotics into routine clinical practice in the 1950s marked a new era in medical care, allowing for the treatment of bacterial infections that were previously life-threatening or lethal [...].
Public Knowledge, Attitudes, and Perceptions of Antimicrobial Resistance in Brazil: Insights from a Nationwide Online Survey [0.03%]
巴西的公众对抗微生物药物耐药性的知识、态度和认知：来自全国在线调查的见解
Victória Ribeiro Silvestre,Gustavo Guimarães Fernandes Viana,Isha Agrawal et al.
Victória Ribeiro Silvestre et al.
Background: Antimicrobial resistance (AMR) poses an escalating threat to global health, agriculture, and the environment, demanding urgent multisectoral action under the One Health framework. Despite global awareness efforts, understanding ...
Pentacyclic Triterpenoid Acids Inhibit the Expression of Quorum Sensing-Related Virulence Factors and the Formation of Biofilm in Pseudomonas aeruginosa PAO1 [0.03%]
五环三萜酸抑制绿脓杆菌QS系统相关毒力因子表达及生物被膜形成能力
Tsiry Rasamiravaka,Adeline Mol,Pierre Duez et al.
Tsiry Rasamiravaka et al.
Background/Objectives: Numerous natural compounds have been reported to exhibit anti-virulence properties against pathogenic bacteria. Particularly, plants constitute a rich source of anti-quorum-sensing (QS) and anti-biofilm compounds with...
Early Antibiotic Prophylaxis in Comatose Patients to Prevent Early-Onset Ventilator-Associated Pneumonia: A Systematic Review and Bayesian Meta-Analysis [0.03%]
昏迷患者早期使用抗生素预防早发性呼吸机相关性肺炎：系统评价和贝叶斯荟萃分析
Riccardo Antolini,Filippo Violini,Roberta Domizi et al.
Riccardo Antolini et al.
Background: Early-onset ventilator-associated pneumonia (EO-VAP) is a frequent complication in comatose patients requiring endotracheal intubation. This systematic review and Bayesian meta-analysis assesses the effectiveness of antibiotic p...
Determinants of Carbapenem-Resistant Klebsiella pneumoniae: Clinical Outcomes and Epidemiological Risk Factors in a Single-Center Cohort Dataset [0.03%]
碳青霉烯耐药肺炎克雷伯菌的决定因素：单一中心队列数据集中的临床结局和流行病学危险因素
Cristiana Ana-Maria Olguța Penea,Violeta Melinte,Claudia Simona Cambrea et al.
Cristiana Ana-Maria Olguța Penea et al.
Background: Carbapenem-resistant K. pneumoniae (CRKP) represents a major challenge in hospitalized patients because of its association with healthcare exposure, restricted antimicrobial options, and adverse clinical outcomes. Microbiologica...
Impact of Narrow Empiric Antibiotic Spectrum and Patient Characteristics on Clinical Outcomes in Bone and Joint Infections: A Retrospective Cohort Study [0.03%]
抗菌谱窄的经验性抗生素治疗及患者特征对骨和关节感染临床结局的影响：一项回顾性队列研究
Lasse Bæk Krag,Anton Alexander Nolte Peterlin,Emil Gleipner-Andersen et al.
Lasse Bæk Krag et al.
Background: Bone and joint infections (BJIs) are a significant clinical challenge due to their tendency to recur, increased healthcare expenses, reduced quality of life, and mortality. Patients with BJIs are a heterogeneous group due to the...
Real-World Evidence: Cefiderocol Therapeutic Drug Monitoring in Critically Ill, Obese Patients with Klebsiella pneumoniae Infections [0.03%]
真实世界证据：头孢迪洛治疗肥胖的难治病原菌肺炎克雷伯杆菌感染患者的用药监测
Alessandra Manca,Alice Palermiti,Silvia Corcione et al.
Alessandra Manca et al.
Background/Objectives: Cefiderocol (FDC) is a siderophore-containing cephalosporin that retains activity against many β-lactamase-producing bacteria, such as New Delhi metallo-β-latamase-producing (NDM) K. pneumoniae. Its use in criticall...
Comparative Biological and Functional Profiling of Single-Position Cysteine Substitutions in the HNP-1-Derived Peptide Pep-H Against Mycobacterium tuberculosis [0.03%]
针对结核分枝杆菌的HNP-1衍生肽Pep-H单点半胱氨酸替代物的生物学及功能特征比较分析
Christian S Carnero Canales,Letícia Oliveira Catarin Nunes,Ariani Rodrigues Aragão et al.
Christian S Carnero Canales et al.
Background/Objectives: Tuberculosis remains a major public health challenge due to the persistence of Mycobacterium tuberculosis (Mtb) and the emergence of multidrug-resistant strains. In this study, Pep-H, an HNP-1-derived antimicrobial pe...
Antimicrobial Resistance in Pediatric Infections: Current Status, Challenges, and Future Directions [0.03%]
儿童感染的抗菌药物耐药性：现状、挑战及未来方向
Clare Dinh,Keykavous Parang
Clare Dinh
Background/Objectives: Antimicrobial resistance in pediatric infections presents a worsening global public health challenge, with antimicrobial resistance (AMR) accounting for more than one million deaths annually and disproportionately aff...
Targeting Membrane Transport and Energy Metabolism for the Identification of Repurposed Drug Candidates Against Neisseria gonorrhoeae Using an In Silico Strategy [0.03%]
基于计算策略的膜转运和能量代谢靶点再利用药物筛选以对抗淋球菌
Inês Pereira,André Pina,Inês Vítor et al.
Inês Pereira et al.
Background/objectives: Neisseria gonorrhoeae is a high-priority pathogen for the development of new therapeutic alternatives. Efflux pumps are attractive drug targets because their inactivation influences N. gonorrhoeae s...