Determinants of COVID-19 and Influenza Vaccination Among People with Diabetes Mellitus in Primary Health Care [0.03%]
糖尿病患者接受新冠和流感疫苗接种的影响因素——基于基层医疗卫生机构的研究
Mariana Rodrigues Fernandes Alves Lemos,Stela de Azevedo Camtamos,Maria Eduarda Perpétuo Vilano et al.
Mariana Rodrigues Fernandes Alves Lemos et al.
Background/Objectives: People with diabetes are more susceptible to viral respiratory infections and worse clinical outcomes related to COVID-19 and influenza. Vaccination is considered an important prevention strategy. This study aimed to ...
A Randomized, Double-Blind, Placebo-Controlled Phase I Study to Evaluate the Safety, Tolerability, and Immunogenicity of an Outer Membrane Vesicle (OMV) Platform-Based Vaccine Administered Intranasally to Healthy Adults [0.03%]
一项随机、双盲、安慰剂对照的I期研究，评估通过鼻腔给药的基于外膜囊泡(OMV)平台疫苗在健康成人受试者中的安全性、耐受性和免疫原性
Heleen Kraan,Anne van der Geest,Dinja Oosterhoff et al.
Heleen Kraan et al.
Background: The COVID-19 pandemic exposed critical gaps in pandemic preparedness and highlighted the need for vaccine platforms capable of rapid adaptation. Outer membrane vesicle (OMV)-based platforms utilizing vesicles derived from geneti...
Development of DuoChol, a Thermostable Inactivated Whole-Cell/B-Subunit Oral Cholera Vaccine in Enteric Capsule [0.03%]
双层霍乱疫苗杜可适的研发及其肠溶胶囊化研究
Manuela Terrinoni,Michael R Lebens,Stefan L Nordqvist et al.
Manuela Terrinoni et al.
Background/Objectives: Cholera remains an important global health problem. Inactivated oral cholera vaccines (OCVs) are essential in the WHO/GTFCC (World Health Organization/Global Task Force on Cholera Control) strategy to end cholera by 2...
Roman Y Kotlyarov,Nikolai V Ravin,Eugenia S Mardanova
Roman Y Kotlyarov
Influenza B virus (IBV) represents a significant global health threat, contributing 20-30% of annual influenza cases and causing substantial morbidity and mortality across all age groups. Current seasonal vaccines demonstrate variable effec...
Assessing Geographic Inequalities in Childhood Immunisation Coverage: A Critical Scoping Review of Spatial Analysis Methods [0.03%]
评估儿童免疫接种覆盖率的地理不平等：空间分析方法批判性综述
Adrien Allorant,Nicole Bergen,M Carolina Danovaro-Holliday et al.
Adrien Allorant et al.
Background: Spatial analysis methods, including model-based geostatistics (MBG), small-area estimation (SAE), and cluster detection, are increasingly used to map subnational immunisation coverage and identify geographic inequalities in low-...
Arming Inactivated Enveloped Virus Vaccines with the GGTA1 Gene: A Potent Method for Amplification of Viral Vaccines Effectiveness and Protection Against Variants [0.03%]
用GGTA1基因武装灭活 enveloped 病毒疫苗：一种增强病毒疫苗效力和防止变体的有效方法
Uri Galili
Uri Galili
This review describes a novel method for increasing the effectiveness of inactivated enveloped whole-virus vaccines by targeting them for extensive uptake by antigen-presenting cells (APCs). Several inactivated whole-virus vaccines with den...
Adult Seroprotection Gaps Against Diphtheria and Tetanus in Urban China: Repeated Cross-Sectional Serosurveillance in Pudong, Shanghai, 2017-2025 [0.03%]
中国城市地区成人白喉和破伤风抗体保护缺口：以上海浦东2017-2025年横断面血清学监测为例
Wanran Cheng,Juan Li,Tian Yang et al.
Wanran Cheng et al.
Background: Adult susceptibility to diphtheria and tetanus may increase as vaccine-induced immunity wanes, yet repeated population-based serosurveillance data in China are limited. Methods: We analyzed annual serosurveys conducted in Pudong...
Family Vaccination Context Predicts HPV Vaccine Uptake Among Medical Students [0.03%]
医学生人乳头瘤病毒疫苗接种情况的家庭背景预测因素
Farah Harb,Shakhnozakhon Mukhtorova,Akarsh Lal et al.
Farah Harb et al.
Background/Objectives: Human papillomavirus (HPV) vaccination is an important cancer prevention strategy, yet uptake remains incomplete. Although provider recommendation is a key driver of HPV vaccination, less is known about how future phy...
Rationally Modified SARS-CoV-2 Spike Protein Impairs ACE2 Binding While Preserving Immunogenicity in Mice [0.03%]
经过理性改造的SARS-CoV-2刺突蛋白在小鼠中削弱ACE2结合但保留免疫原性
Elia Tamagnini,Luca Simonelli,Martin Palus et al.
Elia Tamagnini et al.
Background: While vaccines are designed to elicit targeted immune responses, in some cases, the immunogenic molecules employed can inherently interact with broader host cellular pathways as a secondary consequence. This p...
Zinc: An Emerging Axis of Host-Pathogen Interaction in Tuberculosis [0.03%]
锌：宿主与病原菌在结核分枝杆菌感染过程中相互作用的新轴心
Jordan Holl,Jamie Corro,Bibhuti B Mishra et al.
Jordan Holl et al.
Zinc is an essential micronutrient required by all forms of life, including Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis. Mtb can persist within the host for years and requires a prolonged, multidrug treatment reg...