Protection and Duration of 23-Valent Pneumococcal Polysaccharide Vaccine Against Hospitalization for Community-Acquired Pneumonia in Older Adults with Low Vaccination Coverage: A Multicenter Matched Case-Control Study in China [0.03%]
中国低疫苗接种率的社区老年人群中，23价肺炎球菌多糖疫苗对社区获得性肺炎住院保护效力和持续时间的多中心病例对照研究
Tianchi Yang,Xingqiu Ying,Xiaoqing Wu et al.
Tianchi Yang et al.
Background/Objectives: 23-valent pneumococcal polysaccharide vaccine (PPV23) effectiveness against community-acquired pneumonia (CAP) remains controversial, with critical gaps in low-coverage settings and beyond 5 years post-vaccination. We...
Influenza Vaccination Status and Associated Factors Among Older Adults in Suzhou, China: A Comparative Cross-Sectional Survey [0.03%]
中国苏州市老年人流感疫苗接种状况及影响因素的比较横断面调查
Ningning Du,Shuai Shao,Yuanyuan Zhang et al.
Ningning Du et al.
Background: Influenza poses a serious threat to the health of older adults, and vaccination is a key strategy for prevention. As an economically developed city, Suzhou has a rapidly aging population, yet the influenza vaccination rate among...
Site-Specific Glycosylation Profiling of Protein Subunit and Inactivated Virus Vaccines [0.03%]
蛋白质亚单位和灭活病毒疫苗的位点特异性糖型分析
Zachary C Goecker,Meghan C Burke,Yi Liu et al.
Zachary C Goecker et al.
Background/Objectives: Glycosylation can affect vaccine antigen structure and function, making site-specific glycan characterization relevant to antigen quality and comparability. However, quantitative approaches for comparing glycan microh...
Preventive Strategies and Determinants of Vaccination Compliance Among Older Adults in Rural Amazonian Communities [0.03%]
亚马逊农村社区老年人群疫苗接种影响因素及预防策略研究
Luciana T Pasquel-Muñoz,Ana Lucía Ramírez-Béjar,Joaquín Eduardo Chávez Cano et al.
Luciana T Pasquel-Muñoz et al.
Background/objectives: Respiratory infections are a major cause of morbidity and mortality among older adults. However, vaccination coverage against respiratory pathogens remains suboptimal, particularly in rural and vuln...
Anastasia Kovpak,Sergey Pashkov,Mariia Kostrova et al.
Anastasia Kovpak et al.
Objectives: Antiviral vaccines are usually created by inactivating viruses using physical or chemical methods. Inactivation of poliovirus with β-propiolactone (BPL) has advantages, including the absence of a requirement ...
GnRH-Based Immunocastration Vaccines: Comparative Analysis and Role in Boar Taint Reduction [0.03%]
基于 GnRH 的免疫去势疫苗：比较分析及其在减少公猪异味中的作用
Jisang Kim,Mariusz Skwarczynski,Rachel J Stephenson
Jisang Kim
Boar taint is a persistent challenge in pork production, caused primarily by the accumulation of androstenone and skatole in adipose tissue. It affects 5-40% of uncastrated male pigs and is perceived negatively by a substantial proportion o...
Immunogenicity of a Candidate Hepatitis C Vaccine Based on Non-Structural DNA-Protein Sequences and a Novel Complex Adjuvant [0.03%]
基于非结构DNA-蛋白质序列和新型复杂免疫佐剂的丙型肝炎候选疫苗的免疫原性
Olga V Masalova,Ekaterina I Lesnova,Vyacheslav V Kozlov et al.
Olga V Masalova et al.
Global elimination of hepatitis C virus (HCV) infection requires not only direct-acting antivirals (DAAs) but also the development of a highly effective prophylactic and/or therapeutic vaccine. Background/Objectives: Our aim was to optimize...
Challenges and Future Perspectives for Vaccines Targeting the Tumor Microenvironment [0.03%]
针对肿瘤微环境的疫苗面临的挑战及未来前景
Devin B Lowe,Neda Feizi,Walter J Storkus
Devin B Lowe
Immunotherapies integrating immune checkpoint inhibitors (ICI) represent the current standard of care for many solid cancers, yet they effectively treat only a minority of patients due to intrinsic or acquired resistance mechanisms [...].
Balzhan N Tatibekova,Daniel Yakubovich,Ademi K Sagatbayeva et al.
Balzhan N Tatibekova et al.
Background: Advances in neonatal intensive care in Kazakhstan have improved the survival of preterm infants, including those with very low birth weight (VLBW) and extremely low birth weight (ELBW). However, after hospital...
Vaccination Coverage Among Mothers and Close Contacts of Neonates Hospitalized in NICU in Southern Greece: A Cocooning Strategy Approach [0.03%]
希腊南部NICU住院新生儿母亲及密切接触者的疫苗接种率：一种群落策略的方法
Angeliki Irakleous,Eleni Vergadi,Despoina Gkentzi et al.
Angeliki Irakleous et al.
Background: Neonates and young infants are susceptible to vaccine-preventable diseases because of immature immune responses and delayed acquisition of vaccine-induced protection. As household members and caregivers are a major source of exp...