Engineered mRNA Nanoparticle Platforms for Respiratory Mucosal Delivery [0.03%]
用于呼吸道粘膜递送的工程化mRNA纳米颗粒平台
Rui Jin,Bao-Zhong Wang,Wandi Zhu
Rui Jin
Respiratory mucosal vaccination can induce robust humoral and cellular immune responses, as well as effective mucosal immunity at the primary site of pathogen entry, and has been shown to provide superior protection against respiratory vira...
Post-Pandemic Resurgence of Pertussis in Southeastern Romania, 2024: Vaccination Gaps, Clinical Severity, and Regional Surveillance Performance [0.03%]
2024年罗马尼亚东南部新冠疫情后百日咳复发：疫苗接种缺口、临床严重性及地区监测性能
Alina Plesea Condratovici,Mihaela Debita,Valerian Ionut Stoian et al.
Alina Plesea Condratovici et al.
Background/objectives: Following the COVID-19 pandemic, pertussis resurged sharply across Europe, with 209,674 cases reported in the EU/EEA in 2024. This study characterises the epidemiology of the 2024 pertussis resurgen...
Leveraging Large Language Models to Address Common Vaccination Myths and Misconceptions [0.03%]
利用大型语言模型应对常见的疫苗谣言和误解
Florian Reis,Lea J Bayer,Claudius Malerczyk et al.
Florian Reis et al.
Background/Objectives: Large language models (LLMs) are increasingly used by the public to seek health information, yet their accuracy in addressing common vaccine myths remains unclear. Sycophantic LLM behavior, where models align with rat...
Influenza Vaccination During Pregnancy: A Narrative Review on Maternal and Neonatal Outcomes Associated with Seasonal Influenza Infection [0.03%]
孕期流感疫苗接种：与季节性流感感染相关的母体和新生儿结局的叙述性回顾
María Morales-Suárez-Varela,Isabel Peraita-Costa,Agustín Llopis-Morales et al.
María Morales-Suárez-Varela et al.
Seasonal influenza remains an important public health concern worldwide, and pregnant women represent a particularly vulnerable population due to physiological and immunological changes associated with gestation. Influenza infection during ...
Development and Qualification of a VSV-N IgG ELISA to Assess Vector-Directed Humoral Immunity in VSV-Vectored Vaccine Studies [0.03%]
评估VSV载体疫苗研究中向量定向的体液免疫的VSV-N IgG ELISA的开发和鉴定
Morolayo Ayorinde,Claire Streatfield,Vanaja Kakarla et al.
Morolayo Ayorinde et al.
Background/Objectives: Vesicular Stomatitis Virus (VSV)-vectored vaccines represent a versatile platform for the development of vaccines against infectious diseases. Replication-competent recombinant VSV vectors in which the native glycopro...
Economic Evaluations of New Vaccine Introduction in Middle-Income Countries in the Middle East and North Africa Region: A Systematic Review [0.03%]
中低收入国家引入新疫苗的经济学评价：系统综述中东和北非地区的疫苗经济学评价：系统综述
Chrissy Bishop,Konstantina Politopoulou,Maria Bermudez et al.
Chrissy Bishop et al.
Background/objectives: Middle-income countries (MICs) in the Middle East and North Africa (MENA) face financial and health system barriers when introducing new vaccines. The Gavi MICs approach has supported the introducti...
Potential Roles of Gamma-Delta T Cells in a Bacterial Immun-Ization Model [0.03%]
细菌免疫模型中伽玛德尔塔T细胞的潜在作用
Lee Anne Talbot,Raffi Manjikian,Constantine Bitsaktsis
Lee Anne Talbot
Background/Objective: Francisella tularensis is a highly infectious intracellular pathogen that causes severe pulmonary tularemia following aerosol exposure, yet no licensed vaccine exists. Because infection initiates at the respiratory muc...
Oral HPV Dynamics in MSM Living with HIV in the Nine-Valent HPV Vaccination Era [0.03%]
九价HPV疫苗接种时代HIV感染者MSM人群的口腔HPV自然史研究
Verdiana Zulian,Martina De Sanctis,Silvia Pauciullo et al.
Verdiana Zulian et al.
Background/Objectives: Oral human papillomavirus (HPV) infection is emerging as a key driver of HPV-associated oropharyngeal cancer, especially in high-risk groups such as men who have sex with men (MSM) living with HIV (PLWH). However, evi...
Rosine Ingabire,Julien Nyombayire,Felix Sayinzoga et al.
Rosine Ingabire et al.
Background/objectives: Ebola Virus Disease (EVD) remains a public health threat in sub-Saharan Africa. The 10th Ebola outbreak in the Democratic Republic of the Congo (DRC) in 2018-2020 led the Rwanda Ministry of Health t...
Cost-Effectiveness of Recombinant Versus Live-Attenuated Herpes Zoster Vaccination in China: A Modeling Study Under Self-Paid and National Immunization Scenarios [0.03%]
中国重组水痘带状疱疹疫苗与减毒活疫苗的卫生经济学评价：自费和国家免疫规划情景下的建模研究
Wei Zhang,Song Li,Tianming Yan et al.
Wei Zhang et al.
Objective: The aim was to evaluate the cost-effectiveness of self-paid vaccination using Zoster Vaccine Live (ZVL) and Recombinant Zoster Vaccine (RZV) in China, as well as their inclusion in China's National Immunization...