Recent Advances, Bottlenecks, and Future Directions in Plasmodium falciparum Vaccine Development [0.03%]
近期恶性疟原虫疫苗研发的进展、瓶颈和未来方向
Gulbuse Turan,Maxence J Boggio,Ahmad Syibli Othman et al.
Gulbuse Turan et al.
Malaria remains a major global health burden, with an estimated 282 million cases and 610,000 deaths reported in 2024, disproportionately affecting children under five years of age and pregnant women in sub-Saharan Africa. Although antimala...
Dissolvable Microneedle Delivery of a Replication-Deficient Orthopoxvirus Vaccine: Formulation Screening and Immunogenicity Evaluation for Monkeypox Prevention [0.03%]
可降解微针递送无复制能力正痘病毒疫苗：用于预防猴痘的配方筛选和免疫原性评估
Bin Wang,Kehui Wang,Zhiyao Xu et al.
Bin Wang et al.
Background: The global spread of monkeypox virus (MPXV) highlights an urgent need for thermostable and easily administrable vaccines. Current orthopoxvirus vaccines are limited by cold-chain dependence and inconvenient injection-based deliv...
Generation and Evaluation of a Multi-Epitope Vaccine Against Acinetobacter baumannii, a Nosocomial Bacterial Pathogen [0.03%]
用于医院获得性细菌病原体不动杆菌的多抗原疫苗的设计及评价
Nicolas D Prather,Jadelynn Aki,Sean Jeffreys et al.
Nicolas D Prather et al.
Background/objectives: Multidrug-resistant (MDR) Acinetobacter baumannii (Ab) has emerged as a significant bacterial pathogen responsible for nosocomial infections. The most common clinical manifestations of Ab infection ...
Examining Discordance in Perceptions of COVID-19 and Influenza Vaccine Safety During Pregnancy Among a Cohort of US Adults [0.03%]
从美国成人队列中审视孕期新冠和流感疫苗安全性的知觉分歧
Rachael Piltch-Loeb,Bai Xi Jasmine Chan,Josefina Nuñez Sahr et al.
Rachael Piltch-Loeb et al.
Background/objectives: Vaccination is an important strategy to protect pregnant people, fetuses, and infants from severe influenza and COVID-19. However, as of April 2025 in the United States, only 14% of pregnant women h...
Rational Design of a Chimpanzee Adenoviral-Vector Vaccine Against Yellow Fever Through the Modification of Antigen Transmembrane Domains [0.03%]
通过改变抗原跨膜区进行合理设计的 chimpanzee 腺病毒载体黄热病疫苗
Marta Ulaszewska,Ji Ma,Susan J Morris et al.
Marta Ulaszewska et al.
Background/Objectives: Chimpanzee adenoviral-vectored vaccines have proven to be both safe and effective, with a manufacturing and distribution pipeline capable of rapid global supply, as demonstrated during the COVID-19 pandemic. Yellow fe...
The Status of Measles and Rubella Outbreak Detection, Early Alerts, and Response in Eastern Mediterranean Region (EMR), 2023 [0.03%]
2023年东地中海区域 measles 和 rubella 疫情监测、早期预警和应对情况
Eman Elmahdy,Eltayeb Elfakki,Amany Ghoniem et al.
Eman Elmahdy et al.
Background: Measles and rubella remain major public health concerns in the Eastern Mediterranean Region (EMR), despite regional elimination goals. In 2023, the region experienced an increase in measles outbreaks. This study assessed outbrea...
Impact of the COVID-19 Pandemic on Routine Childhood Vaccination in Oklahoma [0.03%]
COVID-19大流行对俄克拉荷oma儿童常规接种疫苗的影响
Jessica Beetch,Laura A Beebe,Amanda Janitz et al.
Jessica Beetch et al.
Background/Objectives: The COVID-19 pandemic substantially disrupted routine childhood vaccination practices across the United States. Oklahoma, a state characterized by lower socioeconomic indicators and higher levels of vaccine hesitancy,...
Rui M Gil da Costa
Rui M Gil da Costa
Vaccination against human papillomavirus (HPV) has been widely adopted, aiming at preventing infection and, ultimately, the development of HPV-driven uterine cervical neoplasia [...].
Prophylactic HPV Vaccination in Gynaecological Practice: Recommendations, Practices, and Challenges Reported in the ESGO-PERCH HPV Survey [0.03%]
欧洲妇科肿瘤学会（ESGO）人乳头瘤病毒（HPV）调查中关于妇科临床实践中的HPV疫苗预防接种的建议、操作和挑战
Joanna Kacperczyk-Bartnik,Marc Arbyn,Sophie Denoël et al.
Joanna Kacperczyk-Bartnik et al.
Background/objectives: HPV vaccination is highly effective in preventing HPV-related cancers when administered before viral exposure. However, vaccination practices for patients already diagnosed with gynaecological cance...
How to Employ Trained Immunity and Trained Immunity-Based Vaccines to Inhibit Allergic Inflammation [0.03%]
训练免疫在抑制过敏性炎症中的应用及基于训练免疫的疫苗研发进展
Wonho Kim,Dooil Jeoung
Wonho Kim
Trained immunity confers protection against subsequent unrelated infections through metabolic and epigenetic reprogramming. Unlike adaptive immunity, trained innate immunity provides broad, non-specific protection against diverse heterologo...