Vaccination with Carbapenemase KPC-2 and Virulence Factor Pal Provided Robust Protection Against Klebsiella pneumoniae Lung Infection [0.03%]
KPC-2碳青霉烯酶和毒力因子Pal疫苗可有效预防肺炎克雷伯菌肺部感染
Shichun Jiang,Yue Yuan,Yuanda Tang et al.
Shichun Jiang et al.
Objectives: Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) merges multidrug resistance with hypervirulence, posing unprecedented therapeutic challenges. This study aimed to evaluate the efficacy of a recombinant fusion p...
Therapeutic Strategies for Hepatocellular Carcinoma: Current Advances and Future Perspectives [0.03%]
肝细胞癌的治疗策略：目前进展与未来展望
Palaniyandi Muthukutty,Jeong Heo,So Young Yoo
Palaniyandi Muthukutty
Hepatocellular carcinoma (HCC) accounts for approximately 90% of primary liver cancers and remains a leading cause of cancer-related mortality worldwide. The management of HCC poses a major therapeutic challenge due to its pronounced molecu...
A Multi-Country Comparison of Number Needed to Vaccinate for PCV20 and PCV15 in Infants [0.03%]
PCV20和PCV15在各国的婴儿群体中所需接种人数比较研究
Euan Dawson,Maria J Tort,An Ta et al.
Euan Dawson et al.
Background/Objectives: Infant pneumococcal conjugate vaccines (PCV) have significantly reduced pneumococcal morbidity and mortality. Newer vaccines, 15-valent (PCV15) and 20-valent (PCV20), offer broader serotype coverage, potentially preve...
Vaccination with an African Swine Fever Virus Multiepitope Protein Chitosan Nanoparticle-Based Subunit Vaccine Elicits Robust Immune Responses In Vivo [0.03%]
基于壳聚糖纳米颗粒的非洲猪瘟病毒多表位蛋白亚单位疫苗诱导强大的体液免疫和细胞免疫应答
Carolyn M Lee,Raksha Suresh,Patricia A Boley et al.
Carolyn M Lee et al.
Background/objectives: African swine fever virus (ASFV), the causative agent of African swine fever (ASF), is a highly contagious virus affecting both domestic and feral pig populations with mortality rates approaching 10...
Comparative Evaluation of Mucosal Adjuvants for Intranasal Immunization with a Recombinant RSV Prefusion F Protein [0.03%]
鼻内免疫重组RSV融合前F蛋白的粘膜佐剂的比较评估研究
Hongqiao Hu,Lei Cao,Jie Jiang et al.
Hongqiao Hu et al.
Background: Respiratory syncytial virus (RSV) remains a major etiologic agent of acute lower respiratory tract infection (ALRTI). Currently licensed RSV vaccines are administered by intramuscular injection and induce limi...
Comparison of Immune Cell Transfection by Different Vaccine Vectors After Intradermal Injection [0.03%]
不同疫苗载体 intradermal 注射后的免疫细胞转染比较研究
Jiani Liu,Destin T Hinson,Michael J Hansen et al.
Jiani Liu et al.
Background/Objectives: Antigen presenting cells (APCs) and immune cells have unique properties to drive or suppress immune responses. They are therefore key targets for the expression of vaccine antigens or transgene proteins. To better det...
Immunization Against a Conserved Short 13-Amino Acid Receptor-Binding Epitope of FSHβ Reduces Spermatogenesis and Sperm Motility in Male Mice [0.03%]
靶向FSHβ保守的13个氨基酸受体结合表位免疫接种可降低小鼠精子发生和精子运动能力
Xuanti Liu,Like Ran,Jingyi He et al.
Xuanti Liu et al.
Background: Follicle-stimulating hormone (FSH)-based vaccines show the potential to disrupt spermatogenesis without disturbing sexual function and libido in males. Herein, we developed a novel FSH vaccine based on the tan...
Impact of Vaccines Across the Lifespan: A New Perspective in Public Health-Conclusions of an Expert Panel-Part 1 [0.03%]
疫苗的终身影响：公共卫生的新视角——专家小组结论（一）
Roberto Debbag,María L Ávila-Agüero,José Brea et al.
Roberto Debbag et al.
Population aging is the most significant demographic transformation of the 21st century, reshaping health systems, economies, and societies. The biological processes of immunosenescence and inflammaging weaken host defenses, reduce vaccine ...
Impact of Seasonal Nirsevimab Administration in Infants Born During the RSV Circulation Period on RSV-Related Hospitalizations: A Population-Based Study from Emilia-Romagna, Northern Italy [0.03%]
季节性 nirsevimab预防用药对RSV 流行期出生的婴幼儿住院人数的影响：来自意大利北部艾米利亚-罗马涅地区的基于人口的研究
Susanna Esposito,Matteo Puntoni,Giuseppe Maglietta et al.
Susanna Esposito et al.
Background: Respiratory syncytial virus (RSV) is a leading cause of hospitalization in early infancy, with the greatest burden occurring in the first months of life. Following the COVID-19 pandemic, many countries experie...
Immunogenic Properties and Safety of a Quadrivalent Inactivated Subunit Adjuvanted Influenza Vaccine in Adults Aged 18 to 85 Years at the End of the COVID-19 Pandemic in the 2022-2023 Season [0.03%]
在2022-2023年COVID-19大流行结束时，四价裂解亚单位佐剂流感疫苗在18至85岁成人中的免疫原性和安全性
Mikhail P Kostinov,Aristitsa M Kostinova,Sofia Iushkova et al.
Mikhail P Kostinov et al.
Background: SARS-CoV-2 infection has raised concerns about altered immune responses, creating a need to evaluate influenza vaccine performance in the post-COVID period. This study aimed to compare the immunogenicity and safety of a quadriva...