M2 Macrophage-Derived Exosomes Ameliorate BPD by Inhibiting Ferroptosis via Suppression of the ZAKα-p38 Signaling Pathway [0.03%]
M2型巨噬细胞源外泌体通过抑制ZAKα-p38信号通路缓解BPD中的铁死亡
Yuhan Pu,Mingyue Lv,Ru Yan et al.
Yuhan Pu et al.
Background: Bronchopulmonary dysplasia (BPD) is a common lung disease in premature infants. Hyperoxia-induced oxidative stress and ferroptosis are key pathological mechanisms leading to alveolar epithelial (AT) cell injur...
Reshaping Antioxidant Activity via Photoisomerization: A Comparative Theoretical Study of Pterostilbene and Resveratrol [0.03%]
光异构化抗氧化活性的重塑——通过理论计算比较pterostilbene和resveratrol的性质研究
Lei Wang,Chaofan Sun
Lei Wang
This study elucidates the regulatory mechanisms of methoxy substitution and photoexcitation on the antioxidant properties of pterostilbene (PTE) versus resveratrol (RES), employing a combined approach of multi-reference calculations, densit...
Protein Arginine Methyltransferases in γ-Globin Regulation and Sickle Cell Disease: Emerging Connections to Oxidative Stress [0.03%]
蛋白质精氨酸甲基转移酶在γ-珠蛋白调节和镰状细胞病中的作用：与氧化应激的新兴联系
Waseem Chauhan,Rahima Zennadi
Waseem Chauhan
Reactive oxygen species (ROS) are unavoidable byproducts of cellular metabolism and are normally controlled by tightly regulated antioxidant systems. Red blood cells (RBCs) are particularly susceptible to oxidative stress due to their high ...
Apigenin Prevents Ovarian Aging by Regulating Ca2+-Mediated Endoplasmic Reticulum Stress in Laying Chickens [0.03%]
芹菜素通过调节Ca2+介导的内质网应激防止产蛋鸡卵巢衰老
Wanyue Gao,Jing Dong,Yingyu Xiao et al.
Wanyue Gao et al.
The sustainability of egg production in the poultry industry is frequently challenged by the progressive decline in ovarian function as laying chickens age. A primary driver of this reproductive transition is the functional deterioration of...
Polyphenols as Adjuvant Treatment for Heart Failure with Preserved Ejection Fraction (HFpEF): A Review [0.03%]
花青素作为射血分数保留的心力衰竭（HFpEF）辅助治疗的疗效：综述文章
Selma Guimarães Ferreira Medeiros,Rita de Cássia Avellaneda Guimarães,Aline Carla Inada et al.
Selma Guimarães Ferreira Medeiros et al.
Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome driven by systemic inflammation, persistent oxidative stress, endothelial dysfunction, and impaired mitochondrial bioenergetics. Despite recent therapeuti...
Beetroot Juice Enhances Nitrate Metabolism and Endothelial Function but Not Cardiovascular or Strength Performance in Bodybuilders with a History of Anabolic-Androgenic Steroid Abuse: A Crossover Trial [0.03%]
甜菜根汁可改善硝酸盐代谢和血管内皮功能但不能提高使用合成代谢类固醇的健美者的心血管或肌肉性能：交叉试验
Leonardo Santos L da Silva,Leonardo Da Silva Gonçalves,Marcio F Tasinafo Junior et al.
Leonardo Santos L da Silva et al.
Inorganic nitrate (NO3-) has demonstrated therapeutic efficacy in several populations characterised by cardiovascular risk. However, it is unknown whether increasing nitric oxide (NO) bioavailability affects vascular and cardiovascular resp...
Activation of the Nrf2 Signaling Pathway by a Ginseng-Salvia Root-Notoginseng Composite Alleviates Ulcerative DSS-Induced Colitis via Restoring Gut Microbiota and the Intestinal Barrier [0.03%]
人参-丹参-三七复方激活Nrf2信号通路通过恢复肠道菌群和肠屏障缓解DSS诱导的溃疡性结肠炎
Xinao Lyu,Liurong Zhang,Jia Si et al.
Xinao Lyu et al.
Current treatments for ulcerative colitis (UC) often fail to adequately address its multifactorial pathogenesis, which involves oxidative stress, barrier dysfunction, and gut microbiota dysbiosis. This study evaluated the therapeutic potent...
Next-Generation Dietary Antioxidants in Women's Reproductive Health: Mechanisms, Reproductive Outcomes, and Therapeutic Potential [0.03%]
新一代饮食抗氧化剂在女性生殖健康中的作用：机制、生殖结局和治疗潜力
Md Ataur Rahman,Maroua Jalouli,Mohammed Al-Zharani et al.
Md Ataur Rahman et al.
Oxidative stress has emerged as a key factor regulating female fertility, reproductive aging, and the development of various gynecologic and pregnancy-associated diseases. While physiological concentrations of reactive oxygen species play a...
Boric Acid Mitigates Alcohol-Induced Renal Podocyte Injury, Apoptosis, and Oxidative Stress in HBV Transgenic Mice [0.03%]
硼酸缓解酒精引起的HBV转基因小鼠肾足细胞损伤、凋亡和氧化应激
Kubra Sevgin,Pelin Erguven,Sevda Tanrikulu-Kucuk et al.
Kubra Sevgin et al.
Chronic alcohol consumption exacerbates kidney injury, particularly in individuals with hepatitis B virus (HBV) infection. This study investigated the protective effects of boric acid supplementation against alcohol-induced renal damage in ...
Hydroxytyrosol Modulates Arachidonic Acid Metabolism and Purine Catabolism in Individuals with Prediabetes: An Untargeted Metabolomics Study in a Randomized Controlled Trial [0.03%]
羟基酪醇调节空腹血糖受损人群中的花生四烯酸代谢及嘌呤分解代谢：一项非靶向代谢组学的随机对照试验研究
Ignacio Moratilla-Rivera,Elisa Fernández-Millán,Jara Pérez-Jiménez et al.
Ignacio Moratilla-Rivera et al.
Background: Hydroxytyrosol (HT) is a phenolic compound found in extra virgin olive oil that modulates oxidative and inflammatory status. However, clinical trials evaluating HT as a stand-alone supplement remain scarce, and its underlying me...