Biopolymer-Conjugated Human C-Peptide Provides Sustained Neuroprotection and Preserves Axonal Transport in a Mouse Model of NMDA-Induced Retinal Degeneration via Antioxidative Mechanisms [0.03%]
人C肽与生物聚合物结合通过抗氧化机制为NMDA诱导的视网膜退行性变小鼠模型提供持续神经保护并保持轴突运输
Ji-Seok Yoon,Chan-Hee Moon,Tae-Yong Koh et al.
Ji-Seok Yoon et al.
Glutamate excitotoxicity is a key contributor to the pathogenesis of glaucoma, a leading cause of irreversible blindness worldwide; however, the molecular events driving progressive retinal ganglion cell (RGC) loss and axonal degeneration r...
Comparative Phytochemical Profiling and Cellular Antioxidant and Anti-Inflammatory Effects of Wild and Cultivated Vaccinium Berries [0.03%]
野生与栽培越桔的植物化学分析及其细胞抗氧化和抗炎活性比较研究
Denisia Pașca,Ionel Fizeșan,Letiția-Elena Mateș et al.
Denisia Pașca et al.
Vaccinium berries are rich in polyphenolic compounds with recognized health properties; however, studies integrating phytochemical characterization with functional cellular assays remain limited. This study comparatively evaluated wild (Vac...
Identification of Salt-Tolerant Germplasm and Salt-Responsive Genes in Brassica napus Through Phenotypic and Transcriptomic Analyses [0.03%]
基于表型和转录组分析鉴定油菜耐盐种质及响应基因
Lingyu Li,Qi Zhang,Le Tang et al.
Lingyu Li et al.
China's edible oil self-sufficiency rate is only about 30%, and approximately 100 million acres of saline-alkali land are potentially available for rapeseed cultivation. However, salt stress severely inhibits rapeseed growth and yield, maki...
Convergent Lower Expression of Redox-Linked Stress-Adaptation and Synaptic-Plasticity Genes in Major Depressive Disorder Across Seven Postmortem dlPFC Cohorts [0.03%]
氧化还原相关应激适应和突触可塑性基因在主要抑郁障碍中的表达下调：来自死后dlPFC队列的证据
Hubert Klepacki,Michal Ordak,Krystyna Kowalczuk et al.
Hubert Klepacki et al.
Major depressive disorder (MDD) has been linked to oxidative stress, mitochondrial dysfunction, and impaired neuronal plasticity, but the reproducibility of related transcriptomic alterations across postmortem brain cohorts remains uncertai...
Comparative Transcriptomics Reveals Potential Regulatory Mechanisms Underlying Changes in Antioxidant, Anti-Inflammatory, and Other Immune Functions Induced by Bellamya purificata Polysaccharides in Cherax quadricarinatus [0.03%]
比较转录组学揭示了Bellamya purificata多糖诱导的红耳龟能量代谢、抗氧化、抗炎和其它免疫功能变化的潜在调控机制
Chang Yuan,Huizan Yang,Xianhui Pan et al.
Chang Yuan et al.
This study investigated the potential effects of Bellamya purificata polysaccharide (BPP) supplementation in feed on Cherax quadricarinatus, aiming to elucidate its impact on immune function and the underlying regulatory mechanisms. A 60-da...
Neuroprotective Effects of Polyphenol-Rich Corinthian Currant Against a Rotenone Parkinson's Disease Model: Mitigation of MAO-B and Pro-Inflammatory Cytokines Upregulation in Motor and Limbic Brain Regions [0.03%]
富含棓儿茶素的科林斯黑加仑子对罗通定帕金森病模型的神经保护作用：减少运动和边缘脑区MAO-B及促炎细胞因子上调的作用
Eleni Fanarioti,Martha Tsarouchi,Christina Mountaki et al.
Eleni Fanarioti et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder of motor function, while at advanced stages it includes memory deficits and neuropsychiatric conditions. It is characterized primarily by the loss of dopaminergic neurons ...
Hedgehog/GLI Signaling at the Interface of Sterol Metabolism, Mitochondrial ROS Signaling and Cellular Plasticity [0.03%]
刺猬/Gli信号在类固醇代谢、线粒体ROS信号传导和细胞可塑性之间的界面作用
Nicolas Jullien,Sabine François
Nicolas Jullien
Classically, Hedgehog (Hh)/GLI signaling is recognized as a developmental pathway. Increasing evidence indicates that it also contributes to cellular metabolism and adaptation to stress. In this review, we examine the involvement of Hh/GLI ...
Mechanistic Insights into Redox-Dependent Macropinocytosis in Primary Human Neutrophils [0.03%]
原代人中性粒细胞中红氧势态依赖型巨胞饮的机制研究
Stephen A Addo,Imre Babay,Amritha Sreekumar et al.
Stephen A Addo et al.
Macropinocytosis is an actin-driven endocytic process mediating nonspecific uptake of extracellular fluid through membrane ruffling. Neutrophil macropinocytosis has been reported only in limited descriptive studies, and its signaling mechan...
Protective Effects of Natural Products, Functional Foods, and Probiotics on NSAID-Induced Small Intestinal Injury: A Systematic Review with Mechanistic Considerations of Oxidative Stress and Microbiome Modulation [0.03%]
天然产物、功能性食品和益生菌对非甾体抗炎药所致小肠损伤的保护作用：氧化应激和微生物组调节机制的系统评价
Ji Hye Hwang,You-Kyung Choi
Ji Hye Hwang
NSAID-induced small intestinal injury is a clinically significant complication among chronic NSAID and aspirin users, yet effective treatment options remain limited. This systematic review evaluated natural products, functional foods, and p...
Integrated Valorization of Rice Husk by Pressurized Liquid Extraction: Phenolic-Rich Extract Recovery, Reduced 5-HMF Formation, and Preservation of a Cellulosic Co-Product [0.03%]
通过加压液相萃取实现稻壳的综合利用：富含酚类物质的提取物回收，降低羟甲基糠醛生成量和保留纤维质副产物
Milagros Sofia Bustamante-Bernedo,Francisco Paraguay-Delgado,Enrique D Gomez et al.
Milagros Sofia Bustamante-Bernedo et al.
Rice husk, a by-product of rice processing, is a natural source of phenolic compounds and cellulose. Although pressurized liquid extraction (PLE) is an efficient technique for recovering antioxidant compounds, its application to rice husk u...