Overview on Techniques to Construct Tissue Arrays with Special Emphasis on Tissue Microarrays [0.03%]
构造组织阵列技术概要及组织芯片的强调要点
Ulrich Vogel
Ulrich Vogel
With the advent of new histopathological staining techniques (histochemistry, immunohistochemistry, in situ hybridization) and the discovery of thousands of new genes, mRNA, and proteins by molecular biology, the need grew for a technique t...
Identification of New Players in Hepatocarcinogenesis: Limits and Opportunities of Using Tissue Microarray (TMA) [0.03%]
组织芯片(TMA)在肝癌发生新角色鉴定中的应用极限与机会
Luca Quagliata,Manuel Schlageter,Cristina Quintavalle et al.
Luca Quagliata et al.
Liver tumours are among the leading causes of cancer-related death worldwide and hepatocellular carcinoma (HCC) accounts for the vast majority of liver tumours. When detected at an early stage of disease, patients might still be eligible fo...
Andrea Flannery,Jared Q Gerlach,Lokesh Joshi et al.
Andrea Flannery et al.
Carbohydrates play a crucial role in host-microorganism interactions and many host glycoconjugates are receptors or co-receptors for microbial binding. Host glycosylation varies with species and location in the body, and this contributes to...
Mining the Dynamic Genome: A Method for Identifying Multiple Disease Signatures Using Quantitative RNA Expression Analysis of a Single Blood Sample [0.03%]
利用单份血液样本的定量RNA表达分析鉴定多种疾病特征的方法
Samuel Chao,Changming Cheng,Choong-Chin Liew
Samuel Chao
Background: Blood has advantages over tissue samples as a diagnostic tool, and blood mRNA transcriptomics is an exciting research field. To realize the full potential of blood transcriptomic investigations requires improv...
Cancer Biomarkers from Genome-Scale DNA Methylation: Comparison of Evolutionary and Semantic Analysis Methods [0.03%]
基因组规模DNA甲基化癌症生物标志物的演化与语义分析方法比较研究
Ioannis Valavanis,Eleftherios Pilalis,Panagiotis Georgiadis et al.
Ioannis Valavanis et al.
DNA methylation profiling exploits microarray technologies, thus yielding a wealth of high-volume data. Here, an intelligent framework is applied, encompassing epidemiological genome-scale DNA methylation data produced from the Illumina's I...
Integrating Colon Cancer Microarray Data: Associating Locus-Specific Methylation Groups to Gene Expression-Based Classifications [0.03%]
结肠癌微阵列数据的整合：基于基因表达分类的特异甲基化组的关联分析
Ana Barat,Heather J Ruskin,Annette T Byrne et al.
Ana Barat et al.
Recently, considerable attention has been paid to gene expression-based classifications of colorectal cancers (CRC) and their association with patient prognosis. In addition to changes in gene expression, abnormal DNA-methylation is known t...
A Liposome-Based Approach to the Integrated Multi-Component Antigen Microarrays [0.03%]
一种基于脂质体的集成多组分抗原微阵列的方法
Denong Wang
Denong Wang
This report describes an experimental procedure for constructing integrated lipid, carbohydrate, and protein microarrays. In essence, it prints liposomes on nitrocellulose-coated micro-glass slides, a biochip substrate for spotting protein ...
An Overview of NCA-Based Algorithms for Transcriptional Regulatory Network Inference [0.03%]
基于NCA的推断转录调控网络算法综述
Xu Wang,Mustafa Alshawaqfeh,Xuan Dang et al.
Xu Wang et al.
In systems biology, the regulation of gene expressions involves a complex network of regulators. Transcription factors (TFs) represent an important component of this network: they are proteins that control which genes are turned on or off i...
Efficient SNP Discovery by Combining Microarray and Lab-on-a-Chip Data for Animal Breeding and Selection [0.03%]
结合微阵列和芯片实验室数据高效发现SNP以进行动物育种和选种
Chao-Wei Huang,Yu-Tsung Lin,Shih-Torng Ding et al.
Chao-Wei Huang et al.
The genetic markers associated with economic traits have been widely explored for animal breeding. Among these markers, single-nucleotide polymorphism (SNPs) are gradually becoming a prevalent and effective evaluation tool. Since SNPs only ...
Maryam Etebari,Mohsen Navari,Pier Paolo Piccaluga
Maryam Etebari
The traditional methods for detection of chromosomal aberrations, which included cytogenetic or gene candidate solutions, suffered from low sensitivity or the need for previous knowledge of the target regions of the genome. With the advent ...