Fabrication of Homogeneous High-Density Antibody Microarrays for Cytokine Detection [0.03%]
均一高密度抗体微阵列的制备用于细胞因子检测
Ingeborg Hospach,Yvonne Joseph,Michaela Kathrin Mai et al.
Ingeborg Hospach et al.
Cytokine proteins are known as biomarker molecules, characteristic of a disease or specific body condition. Monitoring of the cytokine pattern in body fluids can contribute to the diagnosis of diseases. Here we report on the development of ...
Expression Comparison of Oil Biosynthesis Genes in Oil Palm Mesocarp Tissue Using Custom Array [0.03%]
基于芯片的油棕果肉组织油脂合成基因表达谱分析
Yick Ching Wong,Qi Bin Kwong,Heng Leng Lee et al.
Yick Ching Wong et al.
Gene expression changes that occur during mesocarp development are a major research focus in oil palm research due to the economic importance of this tissue and the relatively rapid increase in lipid content to very high levels at fruit rip...
Alexander Nesterov-Mueller,Frieder Maerkle,Lothar Hahn et al.
Alexander Nesterov-Mueller et al.
In this review, we describe different methods of microarray fabrication based on the use of micro-particles/-beads and point out future tendencies in the development of particle-based arrays. First, we consider oligonucleotide bead arrays, ...
DNA Microarray Analysis on the Genes Differentially Expressed in the Liver of the Pufferfish, Takifugu rubripes, Following an Intramuscular Administration of Tetrodotoxin [0.03%]
市售河豚鱼肝脏中河豚毒素的基因差异表达分析
Takuya Matsumoto,Holger Feroudj,Ryosuke Kikuchi et al.
Takuya Matsumoto et al.
Pufferfish accumulate tetrodotoxin (TTX) mainly in the liver and ovary. This study aims at investigating the effect of TTX accumulation in the liver of cultured specimens of torafugu Takifugu rubripes on the hepatic gene expression by micro...
The Robustness of Pathway Analysis in Identifying Potential Drug Targets in Non-Small Cell Lung Carcinoma [0.03%]
肺癌潜在药物靶标鉴定的途径分析的稳健性
Andrew Dalby,Ian Bailey
Andrew Dalby
The identification of genes responsible for causing cancers from gene expression data has had varied success. Often the genes identified depend on the methods used for detecting expression patterns, or on the ways that the data had been nor...
A New Modified Histogram Matching Normalization for Time Series Microarray Analysis [0.03%]
一种新的用于时间序列微阵列分析的修改直方图匹配规范化方法
Laura Astola,Jaap Molenaar
Laura Astola
Microarray data is often utilized in inferring regulatory networks. Quantile normalization (QN) is a popular method to reduce array-to-array variation. We show that in the context of time series measurements QN may not be the best choice fo...
Chandra K Dixit,Gerson R Aguirre
Chandra K Dixit
Microfluidic-based micromosaic technology has allowed the pattering of recognition elements in restricted micrometer scale areas with high precision. This controlled patterning enabled the development of highly multiplexed arrays multiple a...
Laura Huth,Jörg Jäkel,Edgar Dahl
Laura Huth
Colorectal cancer, a clinically diverse disease, is a leading cause of cancer-related death worldwide. Application of novel molecular diagnostic tests, which are summarized in this article, may lead to an improved survival of colorectal can...
Alberto La Spada,Barnaba Rainoldi,Andrea De Blasio et al.
Alberto La Spada et al.
There is virtually an unlimited number of possible Tissue Microarray (TMA) applications in basic and clinical research and ultimately in diagnostics. However, to assess the functional importance of novel markers, researchers very often turn...
Qualitative and Quantitative Requirements for Assessing Prognostic Markers in Prostate Cancer [0.03%]
前列腺癌诊断标志物的定性和定量要求评估
Christoph Burdelski,Aleksandra Matuszewska,Martina Kluth et al.
Christoph Burdelski et al.
Molecular prognostic markers are urgently needed in order to improve therapy decisions in prostate cancer. To better understand the requirements for biomarker studies, we re-analyzed prostate cancer tissue microarray immunohistochemistry (I...