Profiling Pre-MicroRNA and Mature MicroRNA Expressions Using a Single Microarray and Avoiding Separate Sample Preparation [0.03%]
利用单一微阵列对原前体和成熟MicroRNA表达进行分类及避免单独样本准备
Lin Gan,Bernd Denecke
Lin Gan
Mature microRNA is a crucial component in the gene expression regulation network. At the same time, microRNA gene expression and procession is regulated in a precise and collaborated way. Pre-microRNAs mediate products during the microRNA t...
Testing a Microarray to Detect and Monitor Toxic Microalgae in Arcachon Bay in France [0.03%]
测试一种用于在法国阿卡雄湾检测和监测有毒微藻的微阵列技术
Jessica U Kegel,Yolanda Del Amo,Laurence Costes et al.
Jessica U Kegel et al.
Harmful algal blooms (HABs) occur worldwide, causing health problems and economic damages to fisheries and tourism. Monitoring agencies are therefore essential, yet monitoring is based only on time-consuming light microscopy, a level at whi...
Can Archival Tissue Reveal Answers to Modern Research Questions?: Computer-Aided Histological Assessment of Neuroblastoma Tumours Collected over 60 Years [0.03%]
陈旧组织切片能否解答现代研究问题吗？六十年病理会诊数据的计算机辅助分析：神经母细胞瘤分类案例
Albert Chetcuti,Nicole Mackie,Siamak Tafavogh et al.
Albert Chetcuti et al.
Despite neuroblastoma being the most common extracranial solid cancer in childhood, it is still a rare disease. Consequently, the unavailability of tissue for research limits the statistical power of studies. Pathology archives are possible...
Identifying Potential Regions of Copy Number Variation for Bipolar Disorder [0.03%]
鉴定与双相情感障碍相关的拷贝数变异的潜在区域
Yi-Hsuan Chen,Ru-Band Lu,Hung Hung et al.
Yi-Hsuan Chen et al.
Bipolar disorder is a complex psychiatric disorder with high heritability, but its genetic determinants are still largely unknown. Copy number variation (CNV) is one of the sources to explain part of the heritability. However, it is a chall...
Comparative Analysis of Biologically Relevant Response Curves in Gene Expression Experiments: Heteromorphy, Heterochrony, and Heterometry [0.03%]
基因表达实验中生物相关反应曲线的比较分析：异形态、异时性和异度性
Stuart G Baker
Stuart G Baker
To gain biological insights, investigators sometimes compare sequences of gene expression measurements under two scenarios (such as two drugs or species). For this situation, we developed an algorithm to fit, identify, and compare biologica...
Xiaofei Wang,Shannon Byers
Xiaofei Wang
DNA sequence variations include nucleotide substitution, deletion, insertion, translocation and inversion. Deletion or insertion of a large DNA segment in the genome, referred to as copy number variation (CNV), has caught the attention of m...
Pigeons: A Novel GUI Software for Analysing and Parsing High Density Heterologous Oligonucleotide Microarray Probe Level Data [0.03%]
斑鸠：一种新型GUI软件用于分析和解析高密度异源寡核苷酸微阵列探针水平数据
Hung-Ming Lai,Sean T May,Sean Mayes
Hung-Ming Lai
Genomic DNA-based probe selection by using high density oligonucleotide arrays has recently been applied to heterologous species (Xspecies). With the advent of this new approach, researchers are able to study the genome and transcriptome of...
t-Test at the Probe Level: An Alternative Method to Identify Statistically Significant Genes for Microarray Data [0.03%]
探针水平的T检验：一种识别显微镜阵列数据中具有统计显著性的基因的替代方法
Marcelo Boareto,Nestor Caticha
Marcelo Boareto
Microarray data analysis typically consists in identifying a list of differentially expressed genes (DEG), i.e., the genes that are differentially expressed between two experimental conditions. Variance shrinkage methods have been considere...
Variation of RNA Quality and Quantity Are Major Sources of Batch Effects in Microarray Expression Data [0.03%]
RNA的质量和数量的变异是导致基因微阵表达数据批次效应的主要原因
Mario Fasold,Hans Binder
Mario Fasold
The great utility of microarrays for genome-scale expression analysis is challenged by the widespread presence of batch effects, which bias expression measurements in particular within large data sets. These unwanted technical artifacts can...
Niccolò P Bassani,Federico Ambrogi,Elia M Biganzoli
Niccolò P Bassani
Over the last few years, miRNA microarray platforms have provided great insights into the biological mechanisms underlying the onset and development of several diseases. However, only a few studies have evaluated the concordance between dif...