Small-Molecule Inhibition of Rho/MKL/SRF Transcription in Prostate Cancer Cells: Modulation of Cell Cycle, ER Stress, and Metastasis Gene Networks [0.03%]
前列腺癌细胞中小分子抑制Rho/MKL/SRF转录：细胞周期、内质网应激及转移基因网络的调节作用
Chris R Evelyn,Erika M Lisabeth,Susan M Wade et al.
Chris R Evelyn et al.
Metastasis is the major cause of cancer deaths and control of gene transcription has emerged as a critical contributing factor. RhoA- and RhoC-induced gene transcription via the actin-regulated transcriptional co-activator megakaryocytic le...
Rebecca Jonczyk,Tracy Kurth,Antonina Lavrentieva et al.
Rebecca Jonczyk et al.
Living cell microarrays are a highly efficient cellular screening system. Due to the low number of cells required per spot, cell microarrays enable the use of primary and stem cells and provide resolution close to the single-cell level. Apa...
Giuseppe Merlino,Patrizia Miodini,Biagio Paolini et al.
Giuseppe Merlino et al.
Background: The tumor microenvironment participates in the regulation of tumor progression and influences treatment sensitivity. In breast cancer, it also may play a role in determining the fate of non-invasive lesions su...
Microarray-Based Comparative Genomic and Transcriptome Analysis of Borrelia burgdorferi [0.03%]
基于DNA微阵列的Lyme病螺旋体基因组和转录组比较分析
Radha Iyer,Ira Schwartz
Radha Iyer
Borrelia burgdorferi, the spirochetal agent of Lyme disease, is maintained in nature in a cycle involving a tick vector and a mammalian host. Adaptation to the diverse conditions of temperature, pH, oxygen tension and nutrient availability ...
Time-Resolved Study of Nanoparticle Induced Apoptosis Using Microfabricated Single Cell Arrays [0.03%]
利用微加工单细胞阵列研究纳米颗粒诱导的细胞凋亡动态过程
Peter J F Röttgermann,Kenneth A Dawson,Joachim O Rädler
Peter J F Röttgermann
Cell fate decisions like apoptosis are heterogeneously implemented within a cell population and, consequently, the population response is recognized as sum of many individual dynamic events. Here, we report on the use of micro-patterned sin...
A Mismatch EndoNuclease Array-Based Methodology (MENA) for Identifying Known SNPs or Novel Point Mutations [0.03%]
一种基于错配内切酶阵列(MENA)的检测已知SNP或新点突变的方法学
Josep M Comeron,Jordan Reed,Matthew Christie et al.
Josep M Comeron et al.
Accurate and rapid identification or confirmation of single nucleotide polymorphisms (SNPs), point mutations and other human genomic variation facilitates understanding the genetic basis of disease. We have developed a new methodology (call...
A Double-Hybridization Approach for the Transcription- and Amplification-Free Detection of Specific mRNA on a Microarray [0.03%]
一种用于微阵列上的特异性mRNA的无转录和扩增检测的双杂交方法
Michaela Haider,Thomas Haselgrübler,Alois Sonnleitner et al.
Michaela Haider et al.
A double-hybridization approach was developed for the enzyme-free detection of specific mRNA of a housekeeping gene. Targeted mRNA was immobilized by hybridization to complementary DNA capture probes spotted onto a microarray. A second hybr...
Glycoarray Technologies: Deciphering Interactions from Proteins to Live Cell Responses [0.03%]
糖芯片技术：从蛋白质到活细胞应答的相互作用分析
Tania M Puvirajesinghe,Jeremy E Turnbull
Tania M Puvirajesinghe
Microarray technologies inspired the development of carbohydrate arrays. Initially, carbohydrate array technology was hindered by the complex structures of glycans and their structural variability. The first designs of glycoarrays focused o...
Identification of Critical Region Responsible for Split Hand/Foot Malformation Type 3 (SHFM3) Phenotype through Systematic Review of Literature and Mapping of Breakpoints Using Microarray Data [0.03%]
通过系统文献回顾和使用微阵列数据定位断点来识别裂手/足畸形3型表型的关键区域
Catherine F Li,Katie Angione,Jeff M Milunsky
Catherine F Li
Split hand/foot malformation (SHFM) is a limb malformation with underdeveloped or absent central digital rays, clefts of hands and feet, and variable syndactyly of the remaining digits. There are six types of SHFM. Here, we report a boy wit...
Jinming Song,Haipeng Shao
Jinming Song
Cytogenetic analysis is essential for the diagnosis and prognosis of hematopoietic neoplasms in current clinical practice. Many hematopoietic malignancies are characterized by structural chromosomal abnormalities such as specific translocat...