Decentralized Clinical Trials: Governance, Ethics and Medico-Legal Issues for the New Paradigm of Research with a Focus on Cardiovascular Field [0.03%]
去中心化临床试验：新研究范式下的治理、伦理和医学法律问题（以心血管领域为重点）
Elena Tenti,Giuseppe Basile,Claudia Giorgetti et al.
Elena Tenti et al.
The evolution of decentralized clinical trials, driven by advanced digital technologies, is transforming traditional clinical research. It introduces innovative methods for informed consent, remote patient monitoring, and data analysis, enh...
Sex-Specific Safety Signals of Trelegy Ellipta: A FAERS Pharmacovigilance Analysis [0.03%]
Trelegy Ellipta的FAERS药物警戒分析中的性别特异性安全性信号研究
Josef Yayan,Christian Biancosino,Marcus Krüger et al.
Josef Yayan et al.
Background: Trelegy Ellipta is a widely prescribed triple inhaler therapy for chronic obstructive pulmonary disease (COPD). Although its clinical efficacy is well established, evidence on sex-specific differences in adverse event (AE) profi...
Reproducibility Examination of Histopathological Growth Patterns of Liver Metastases in a Retrospective, Consecutive, Single-Center, Cohort Study with Literature Review [0.03%]
回顾性连续单中心队列研究中肝脏转移病灶的病理生长模式的可重复性分析及文献回顾
Anita Sejben,Szintia Almási,Boglárka Pósfai et al.
Anita Sejben et al.
Objectives: Histopathological growth patterns (HGPs) of liver metastases have been shown to possess prognostic significance. To date, only 2 studies have evaluated the reproducibility of HGP assessment. The aim of our stu...
Prevalence and Mortality Outcomes of Melioidosis in Thalassemia: A Systematic Review and Meta-Analysis [0.03%]
地中海贫血患者贝氏菌病的患病率和死亡结局：系统评价和.meta.分析
Jongkonnee Thanasai,Kritsada Singha,Atthaphong Phongphithakchai et al.
Jongkonnee Thanasai et al.
Background. Melioidosis is a severe infection caused by Burkholderia pseudomallei and is endemic in regions with a high prevalence of thalassemia. Patients with thalassemia are thought to be at increased risk due to iron overload, splenecto...
Efficacy of Extracorporeal Shockwave Therapy in the Management of Chronic Diabetic Foot Ulcer: A Systematic Review and Meta-Analysis [0.03%]
体外冲击波治疗糖尿病慢性足溃疡疗效的系统评价和meta分析研究
Maria Ruiz-Muñoz,Lidia Rueda-Zapata,Francisco-Javier Martinez-Barrios et al.
Maria Ruiz-Muñoz et al.
Introduction: This study will explore the effectiveness of current extracorporeal shockwave therapies in ulcer healing in diabetic foot disease compared to the standard of care. Methods: The systematic review and meta-analysis were performe...
Genetic Variations of the FUT3 Gene in Le(a-b-) Individuals and Their Association with Lewis Antibody Responses [0.03%]
Lewis(a-b-)个体FUT3基因遗传多态性及其与Lewis抗体反应的关系研究
Oytip Nathalang,Piyathida Khumsuk,Wiradee Sasikarn et al.
Oytip Nathalang et al.
Background: The biosynthesis of Lewis (Le) antigens depends on the FUT3 gene, encoding an α(1,3/4)-fucosyltransferase. Individuals lacking functional FUT3 exhibit a Le(a-b-) phenotype, regardless of secretor status. Methods: This study det...
The Pathophysiology of Wharton's Jelly and Its Impact on Fetal and Neonatal Outcomes: A Comprehensive Literature Review [0.03%]
沃顿胶的病理生理学及其对胎儿和新生儿结局的影响：全面文献综述
Tudor-Andrei Butureanu
Tudor-Andrei Butureanu
Wharton's jelly (WJ), the mucoid connective tissue of the umbilical cord, provides essential protection to the umbilical vessels against mechanical stress. While research into WJ-derived stem cells for regenerative medicine has surged, the ...
The Role of Delayed Interval Debulking Surgery (DIDS) in the Surgical Treatment of Advanced Epithelial Ovarian Cancer: A Retrospective Cohort from an ESGO-Certified Center [0.03%]
延迟间隔减瘤术(DIDS)在晚期卵巢上皮性癌外科治疗中的作用：来自欧洲妇科肿瘤学会（ESGO）认证中心的回顾队列研究
Dimitrios Zouzoulas,Iliana Sofianou,Panagiotis Tzitzis et al.
Dimitrios Zouzoulas et al.
Background/Objectives: Patients with advanced ovarian cancer with a high tumor burden typically undergo neoadjuvant chemotherapy (NACT) followed by interval debulking surgery. The optimal number of NACT cycles remains undefined: although th...
A Bioinformatics-Driven ceRNA Network in Stomach Adenocarcinoma: Identification of Novel Prognostic mRNA-miRNA-lncRNA Interactions [0.03%]
胃腺癌中基于生物信息学的ceRNA网络的研究：新型mRNA-miRNA-lncRNA互作及预后标志物识别
Ebtihal Kamal,Zainab Mohammed Mahmoud Omar,Ayman Geddawy et al.
Ebtihal Kamal et al.
Background: Stomach adenocarcinoma is a major contributor to worldwide mortality and significantly impacts life expectancy. The main objective of the current study was to identify a prognostic biomarker for stomach adenoc...
The Validation of the Persian Version of the ID-Migraine Questionnaire [0.03%]
波斯语ID-Migraine量表的有效性验证
Amirreza Nasirzadeh,Amir Ghasemi,Alireza Afshari-Safavi et al.
Amirreza Nasirzadeh et al.
Background: Migraine is often not diagnosed or treated properly, despite being a common condition. The ID-migraine is a brief, self-administered test developed as a valuable tool for screening and diagnosing migraine in primary care setting...