Ortho- and Meta-monochlorinated Biphenyls Suppress Humoral Immunity and Exert Toxic Effects on Mouse Liver Cells [0.03%]
邻、间单氯化联苯抑制体液免疫及对小鼠肝细胞的毒性作用
D O Egorova,S V Gein,N A Korolev et al.
D O Egorova et al.
Widespread environmental contamination with polychlorinated biphenyls (PCBs) leads to serious health problems for humans and animals. Our main focus should be on studying the negative effects of exposure to medium- and highly chlorinated PC...
PepString Server As a Tool to Search for Short Amino Acid Subsequences: Identification of Potential Amyloid-Beta Targets [0.03%]
PepString服务器作为一个搜索短氨基酸亚序列的工具：识别潜在的β淀粉样肽目标服务器作为一个搜索短氨基酸亚序列的工具：识别潜在的amyloid-beta目标
S A Kozin,A A Anashkina,D G Matsuga et al.
S A Kozin et al.
This paper presents a new bioinformatics tool to meet the needs of researchers in the search for short (≥ 3) amino acid subsequences in protein sequences annotated in public databases (UniprotKB, SwissProt) and illustrates its efficacy wit...
The Design, Synthesis, and Evaluation of the Biological Activity of Hydroxamic Derivatives of Sorafenib [0.03%]
索拉非尼羟胺衍生物的设计、合成及生物活性评价
A A Kleymenova,I A Abramov,Ya V Tkachev et al.
A A Kleymenova et al.
Sorafenib is a multiple tyrosine kinase inhibitor that is used in the treatment of liver and renal cancers. We synthesized the hydroxamic derivatives of sorafenib bearing the pharmacophore elements of zinc-dependent histone deacetylase inhi...
p2rx3 Knockout Mice Have Altered Energy Metabolism in Hippocampal Neurons [0.03%]
P2RX3基因敲除小鼠海马神经元能量代谢改变
A S Zelentsova,M V Pokrovskii,E A Patrakhanov et al.
A S Zelentsova et al.
The hippocampus is a key component of the brain that is associated with the formation of longterm memory, the energy metabolism of neurons playing a pivotal role in its mechanisms. The P2X3 receptor in the hippocampus is considered an attra...
The Generation and Characterization of a Mouse Embryonic Stem Cell Line with Psmb9 Immunoproteasome Gene Knockout [0.03%]
一株不含免疫蛋白酶体基因的鼠胚胎干细胞系的建立与鉴定
D V Kriger,U I Podenkova,A A Kuzmin et al.
D V Kriger et al.
Immunoproteasomes, a unique type of proteasome complex, play a critical role in antigen presentation and cellular homeostasis. Unlike the constitutive 20S proteasome, the catalytic subunits β1, β2, and β5 in the immunoproteasome are repl...
The Impact of the Intracellular Domains of Chimeric Antigenic Receptors on the Properties of CAR T-cells [0.03%]
嵌合抗原受体胞内结构域对CAR-T细胞特性的影响
D V Volkov,V M Stepanova,I A Yaroshevich et al.
D V Volkov et al.
The advent of the T-cell engineering technology using chimeric antigen receptors (CARs) has revolutionized the treatment of hematologic malignancies and reoriented the direction of research in the field of immune cell engineering and immuno...
Test System for Studying Biotin Transport upon SLC5A6 Gene Inactivation [0.03%]
SLC5A6基因失活下的生物素转运检测系统研究
A Yu Rudenko,P A Zotova,O A Averina et al.
A Yu Rudenko et al.
This paper introduces a test system for the investigation of biotin transport following inactivation of the SLC5A6 gene, which encodes the sodium-dependent multivitamin transporter SLC5A6. The aim was to develop a method for assessing the e...
Targeted Nanoliposomes for the Delivery of Boronophenylalanine into HER2-Positive Cells [0.03%]
靶向纳米脂质体将硼苯丙氨酸递送进入HER2阳性细胞中
G M Proshkina,E I Shramova,A B Mirkasymov et al.
G M Proshkina et al.
Boron neutron capture therapy (BNCT) is a rapidly developing field of radiation therapy for cancer that is based on the accumulation of the radiosensitive 10B isotope in cancer cells, followed by tumor irradiation with thermal neutrons. Wid...
RNA Interference of the Genes Associated with the Invasion of Brain Tumor Cells [0.03%]
与脑肿瘤细胞侵袭有关的基因的RNA干扰作用研究
M A Dymova,O A Kartina,D V Drokov et al.
M A Dymova et al.
High-grade gliomas are among the most aggressive malignant pathologies of the brain. The high invasive potential of tumor cells causes relapses of the disease even after radical resection of the tumor. The signatures of the genes associated...
Store-Operated Calcium Entry As an Important Mechanism of Tumor Adaptation to an Aggressive Microenvironment [0.03%]
store-operated钙离子进入作为肿瘤适应侵袭性微环境的重要机制
A Yu Skopin,E V Kaznacheyeva
A Yu Skopin
Calcium signaling ensures efficient cellular functioning; calcium homeostasis disruption leaves behind detrimental sequelae for the cell both under calcium excess and deficiency conditions. Malignant transformation is accompanied by signifi...