Reconstruction and Paleogenetic Characterization of the Genome of Princess Maria Vsevolozha, Wife of Grand Prince Vsevolod the Big Nest [0.03%]
重建并进行古基因组特征分析公主玛丽亚·韦谢沃洛日卡的基因组，她是大公弗拉基米尔·大窠的儿子弗谢沃洛德的大窠的妻子
K V Zhur,M V Leonova,F S Sharko et al.
K V Zhur et al.
Grand Prince of Vladimir Vsevolod the Big Nest and his wife Maria Vsevolozha (Shvarnovna) had twelve children, eight of whom were sons; Grand Prince Alexander Yaroslavich Nevsky was their grandson. Two competing hypotheses exist regarding t...
COGcollator 2.0: A Tool for Analyzing Distant Evolutionary Relationships Among Families of Homologous Proteins [0.03%]
COG拼接器2.0：一种分析同源蛋白家族之间遥远进化关系的工具
D V Dibrova,S Y Rykov
D V Dibrova
The analysis of protein evolutionary relationships is of both theoretical and practical significance. Identifying and characterizing evolutionary relationships between the components of protein complexes and metabolic enzymes fosters a deep...
S D Margasyuk,A L Kuznetsova,D A Skvortsov et al.
S D Margasyuk et al.
Genital lichen sclerosus (GLS) is a chronic inflammatory dermatosis that affects the genital skin. Despite different clinical manifestations, the pathogenesis of GLS in men and women is believed to be common and is attributed to a combinati...
Effect of Endocytosis Inhibitors on the Cytotoxicity and Antitumor Activity of Anti-GD2 ADCs [0.03%]
内吞抑制剂对GD2抗体药物偶联物细胞毒性和抗肿瘤活性的影响
M M Titov,I V Kholodenko,D V Kalinovsky et al.
M M Titov et al.
Cancer remains a critical public health challenge, and developing novel approaches to cancer therapy is highly relevant. Targeted tumor therapy using antibody-drug conjugates (ADCs) has already demonstrated its efficacy in multiple tumors. ...
The Transcriptional Kinases CDK8/19 in the Regulation of the Macrophage Inflammatory Response [0.03%]
调控巨噬细胞炎性反应的转录激酶CDK8/19
A N Neznamov,Yu A Oparina,D M Dolmatova et al.
A N Neznamov et al.
Macrophage dysfunction is a key pathogenetic mechanism in the progression of a wide range of human chronic inflammation conditions, including atherosclerosis, rheumatoid arthritis, and metabolic disorders. The CDK8 and CDK19 paralogous kina...
The Potential Role of the Bacterial Persister Formation Gene ptsH in Hypervirulence Development in Klebsiella pneumoniae [0.03%]
肺炎克雷伯菌ptsH基因与耐药及高毒力之间的关系研究进展
A V Tutel&#x;yan,N V Vlasenko,V M Pisarev et al.
A V Tutel&#x;yan et al.
Persistence - i.e., the ability to exist in a metabolically inactive form - allows bacteria to accumulate genetic advantages. The evolution of the pathogenic potential of Klebsiella pneumoniae has led to the emergence of strains simultaneou...
Isolation of Monoclonal Neutralizing Single-Domain Antibodies Against Clostridioides difficile Toxin B [0.03%]
抗艰难梭菌毒素B单域中和抗体的筛选及鉴定
I A Alekseeva,A S Ungur,I A Favorskaya et al.
I A Alekseeva et al.
The Clostridioides difficile infection (CDI) is one of the most common nosocomial infections around. The key pathogenicity factors of this bacterium include the toxins A and B that cause the disease symptoms. Neutralization of these toxins ...
Genetic Determinants of Cellular Homeostasis Contributing to the Risk of Type 2 Diabetes [0.03%]
遗传决定因子与细胞稳态及2型糖尿病风险的关系
Y R Timasheva,O V Kochetova,T R Nasibullin et al.
Y R Timasheva et al.
Genetic variation in the genes involved in the maintenance of cellular homeostasis may influence susceptibility to type 2 diabetes (T2D). However, the nature of the interplay among these loci and their prognostic value remains unclear. In t...
T F Kikhai,A V Mashkovskaia,T S Oretskaya et al.
T F Kikhai et al.
significant impact on the pathogenesis of viral infections by acting as both positive and negative regulators of viral gene expression. This review summarizes the available data on lncRNAs associated with human immunodeficiency virus type 1...
Senolytic Properties of DR5-Selective TRAIL in Pancreatic Cancer Cell Lines [0.03%]
在胰腺癌细胞系中选择性激活DR5的TRAIL具有senolytic作用
A A Isakova,N V Antipova,D V Mazur et al.
A A Isakova et al.
Pancreatic adenocarcinoma is one of the most aggressive cancers. Its treatment relies on conventional chemotherapy agents; particularly gemcitabine. Chemotherapy is known to induce cell cycle arrest and the development of a senescent phenot...