Pathogenesis of PM2.5-Related Disorders in Different Age Groups: Children, Adults, and the Elderly [0.03%]
不同年龄段PM2.5相关疾病发病机制研究——儿童、成人和老年人
Teerachai Amnuaylojaroen,Nichapa Parasin
Teerachai Amnuaylojaroen
The effects of PM2.5 on human health fluctuate greatly among various age groups, influenced by a range of physiological and immunological reactions. This paper compares the pathogenesis of the disease caused by PM2.5 in people of different ...
Opposite and Differently Altered Postmortem Changes in H3 and H3K9me3 Patterns in the Rat Frontal Cortex and Hippocampus [0.03%]
大鼠前额叶皮质和海马神经元中组蛋白H3和H3K9三甲基化在死亡后不同模式的改变
Karolina Dulka,Noémi Lajkó,Kálmán Nacsa et al.
Karolina Dulka et al.
Temporal and spatial epigenetic modifications in the brain occur during ontogenetic development, pathophysiological disorders, and aging. When epigenetic marks, such as histone methylations, in brain autopsies or biopsy samples are studied,...
Exploring Transcriptional Regulation of Beta Cell SASP by Brd4-Associated Proteins and Cell Cycle Control Protein p21 [0.03%]
探索Brd4相关蛋白和细胞周期调控蛋白p21对β细胞分泌作用的影响机制研究
Jasmine Manji,Jasmine Pipella,Gabriel Brawerman et al.
Jasmine Manji et al.
Type 1 diabetes (T1D) is a metabolic disease resulting from progressive autoimmune destruction of insulin-producing pancreatic beta cells. Although the majority of beta cells are lost in T1D, a small subset undergoes senescence, a stress re...
Wiesława Leśniak
Wiesława Leśniak
Epidermis is the outer skin layer built of specialized cells called keratinocytes. Keratinocytes undergo a unique differentiation process, also known as cornification, during which their gene expression pattern, morphology and other propert...
Inheritance of Stress Responses via Small Non-Coding RNAs in Invertebrates and Mammals [0.03%]
无脊椎动物和哺乳动物通过小非编码RNA传递应激反应遗传性状
Maria C Ow,Sarah E Hall
Maria C Ow
While reports on the generational inheritance of a parental response to stress have been widely reported in animals, the molecular mechanisms behind this phenomenon have only recently emerged. The booming interest in epigenetic inheritance ...
Epigenetic Features in Newborns Associated with Preadolescence Lung Function and Asthma Acquisition during Adolescence [0.03%]
新生儿表观遗传特征与学龄前肺功能及青春期哮喘发病的关系
Mohammad Nahian Ferdous Abrar,Yu Jiang,Hongmei Zhang et al.
Mohammad Nahian Ferdous Abrar et al.
The association between newborn DNA methylation (DNAm) and asthma acquisition (AA) during adolescence has been suggested. Lung function (LF) has been shown to be associated with asthma risk and its severity. However, the role of LF in the a...
A Comparative Analysis of Mouse Imprinted and Random X-Chromosome Inactivation [0.03%]
小鼠印记X染色体与随机X染色体失活的比较分析
Rebecca M Malcore,Sundeep Kalantry
Rebecca M Malcore
The mammalian sexes are distinguished by the X and Y chromosomes. Whereas males harbor one X and one Y chromosome, females harbor two X chromosomes. To equalize X-linked gene expression between the sexes, therian mammals have evolved X-chro...
Targeting SWI/SNF Complexes in Cancer: Pharmacological Approaches and Implications [0.03%]
靶向癌症中的SWI/SNF复合物：药理学方法及其意义
Megan R Dreier,Jasmine Walia,Ivana L de la Serna
Megan R Dreier
SWI/SNF enzymes are heterogeneous multi-subunit complexes that utilize the energy from ATP hydrolysis to remodel chromatin structure, facilitating transcription, DNA replication, and repair. In mammalian cells, distinct sub-complexes, inclu...
Samuel Jesus Luchsinger-Morcelle,Joost Gribnau,Hegias Mira-Bontenbal
Samuel Jesus Luchsinger-Morcelle
Compensation for the gene dosage disequilibrium between sex chromosomes in mammals is achieved in female cells by repressing one of its X chromosomes through a process called X chromosome inactivation (XCI), exemplifying the control of gene...
Angio-Long Noncoding RNA MALAT1 (rs3200401) and MIAT (rs1061540) Gene Variants in Ovarian Cancer [0.03%]
血管长链非编码RNA MALAT1（rs3200401）和MIAT（rs1061540）基因变异与卵巢癌的关系
Manal S Fawzy,Afaf T Ibrahiem,Dalia Mohammad Osman et al.
Manal S Fawzy et al.
The genotyping of long non-coding RNA (lncRNA)-related single-nucleotide polymorphisms (SNPs) could be associated with cancer risk and/or progression. This study aimed to analyze the angiogenesis-related lncRNAs MALAT1 (rs3200401) and MIAT ...