Xing Zhang,Robert M Blumenthal,Xiaodong Cheng
Xing Zhang
The post-genomic era has ushered in the extensive application of epigenetic editing tools, allowing for precise alterations of gene expression. The use of reprogrammable editors that carry transcriptional corepressors has significant potent...
Epigenetic Regulation of Neural Stem Cells in Developmental and Adult Stages [0.03%]
表观遗传调控神经干细胞的发育和成年期功能
Shu Kunoh,Hideyuki Nakashima,Kinichi Nakashima
Shu Kunoh
The development of the nervous system is regulated by numerous intracellular molecules and cellular signals that interact temporally and spatially with the extracellular microenvironment. The three major cell types in the brain, i.e., neuro...
Structural and Biochemical Characterization of the Nucleosome Containing Variants H3.3 and H2A.Z [0.03%]
含H3.3和H2A.Z变体的核小体的结构与生化分析
Harry Jung,Vladyslava Sokolova,Gahyun Lee et al.
Harry Jung et al.
Variant H3.3, along with H2A.Z, is notably enriched at promoter regions and is commonly associated with transcriptional activation. However, the specific molecular mechanisms through which H3.3 influences chromatin dynamics at transcription...
Emerging Approaches to Profile Accessible Chromatin from Formalin-Fixed Paraffin-Embedded Sections [0.03%]
新兴的从福尔马林固定石蜡包埋切片中绘制可访问染色质谱的方法
Vishnu Udayakumaran Nair Sunitha Kumary,Bryan J Venters,Karthikeyan Raman et al.
Vishnu Udayakumaran Nair Sunitha Kumary et al.
Nucleosomes are non-uniformly distributed across eukaryotic genomes, with stretches of 'open' chromatin strongly associated with transcriptionally active promoters and enhancers. Understanding chromatin accessibility patterns in normal tiss...
Statistical Models for High-Risk Intestinal Metaplasia with DNA Methylation Profiling [0.03%]
基于DNA甲基化谱的高危肠上皮内瘤变统计学模型研究
Tianmeng Wang,Yifei Huang,Jie Yang
Tianmeng Wang
We consider the newly developed multinomial mixed-link models for a high-risk intestinal metaplasia (IM) study with DNA methylation data. Different from the traditional multinomial logistic models commonly used for categorical responses, th...
The Role of Different TET Proteins in Cytosine Demethylation Revealed by Mathematical Modeling [0.03%]
数学建模揭示TET蛋白在胞嘧啶去甲基化中的作用
Karolina Kurasz,Joanna Rzeszowska-Wolny,Ryszard Oliński et al.
Karolina Kurasz et al.
In living cells, some reactions can be conducted by more than one enzyme and sometimes it is difficult to establish which enzyme is responsible. Such is the case with proteins from the TET family, capable of converting 5-methyl-2'-deoxycyti...
Blood Vitamin C Levels of Patients Receiving Immunotherapy and Relationship to Monocyte Subtype and Epigenetic Modification [0.03%]
免疫治疗患者的血液维生素C水平及其与单核细胞亚型和表观遗传修饰的关系
Ben Topham,Millie de Vries,Maria Nonis et al.
Ben Topham et al.
The treatment of metastatic melanoma has been revolutionised by immunotherapy, yet a significant number of patients do not respond, and many experience autoimmune adverse events. Associations have been reported between patient outcome and m...
Deciphering the Diversity in Bacterial Transporters That Salvage Queuosine Precursors [0.03%]
解读细菌转运蛋白的多样性以回收呫吨碱前体
Samia Quaiyum,Yifeng Yuan,Paul J Kuipers et al.
Samia Quaiyum et al.
Queuosine (Q) is a modification of the wobble base of tRNA harboring GUN anticodons with roles in decoding accuracy and efficiency. Its synthesis is complex with multiple enzymatic steps, and several pathway intermediates can be salvaged. T...
TNFR1 Absence Is Not Crucial for Different Types of Cell Reaction to TNF: A Study of the TNFR1-Knockout Cell Model [0.03%]
TNFR1缺失对肿瘤坏死因子的细胞反应类型不是至关重要—肿瘤坏死因子受体1基因敲除模型研究
Alina A Alshevskaya,Julia A Lopatnikova,Julia V Zhukova et al.
Alina A Alshevskaya et al.
Background: One of the mechanisms regulating the biological activity of tumor necrosis factor (TNF) in cells is the co-expression of TNFR1/TNFR2 receptors. A model with a differential level of receptor expression is requi...
Unveiling Gene Interactions in Alzheimer's Disease by Integrating Genetic and Epigenetic Data with a Network-Based Approach [0.03%]
基于网络的整合遗传和表观遗传数据揭示阿尔茨海默病中的基因互作
Keith L Sanders,Astrid M Manuel,Andi Liu et al.
Keith L Sanders et al.
Alzheimer's Disease (AD) is a complex disease and the leading cause of dementia in older people. We aimed to uncover aspects of AD's pathogenesis that may contribute to drug repurposing efforts by integrating DNA methylation and genetic dat...