α-Crystalline Domains and Intrinsically Disordered Regions Can Work in Parallel to Induce Accumulation of MBD6 at Chromocenters in Arabidopsis thaliana [0.03%]
拟南芥MBD6在染色中心积累依赖于其自身α-晶状体结构域和内在无序区的并行作用
Brandon A Boone,Cristy P Mendoza,Noah J Behrendt et al.
Brandon A Boone et al.
Proteins are localized and concentrated at cellular and genomic locations for specific and efficient functions. Efforts to understand protein accumulation in eukaryotic organisms have primarily focused on multivalent interactions between in...
Genome-Wide Methylation Profiling of Peripheral T-Cell Lymphomas Identifies TRIP13 as a Critical Driver of Tumor Proliferation and Survival [0.03%]
全基因组甲基化谱分析外周T细胞淋巴瘤鉴定出TRIP13是肿瘤增殖和存活的关键驱动因素
Pawel Nowialis,Julian Tobon,Katarina Lopusna et al.
Pawel Nowialis et al.
Cytosine methylation contributes to the regulation of gene expression and normal hematopoiesis in mammals. It is catalyzed by the family of DNA methyltransferases that include DNMT1, DNMT3A, and DNMT3B. Peripheral T-cell lymphomas (PTCLs) r...
Sex-Specific Associations between Prenatal Exposure to Bisphenols and Phthalates and Infant Epigenetic Age Acceleration [0.03%]
孕期接触双酚和邻苯二甲酸盐与婴幼儿表观遗传学老化之间的性别特异性关联
Gillian England-Mason,Sarah M Merrill,Jiaying Liu et al.
Gillian England-Mason et al.
We examined whether prenatal exposure to two classes of endocrine-disrupting chemicals (EDCs) was associated with infant epigenetic age acceleration (EAA), a DNA methylation biomarker of aging. Participants included 224 maternal-infant pair...
Unravelling the Epigenetic Code: DNA Methylation in Plants and Its Role in Stress Response [0.03%]
植物表观遗传密码之DNA甲基化及其应激反应中的作用机制研究
Emanuela Talarico,Alice Zambelli,Fabrizio Araniti et al.
Emanuela Talarico et al.
Environmental stress significantly affects plant growth, development, and survival. Plants respond to stressors such as temperature fluctuations, water scarcity, nutrient deficiencies, and pathogen attacks through intricate molecular and ph...
Multiomics Screening Identified CpG Sites and Genes That Mediate the Impact of Exposure to Environmental Chemicals on Cardiometabolic Traits [0.03%]
多组学筛选识别出介导环境化学物质暴露影响心代谢性状的CpG位点和基因
Majid Nikpay
Majid Nikpay
An understanding of the molecular mechanism whereby an environmental chemical causes a disease is important for the purposes of future applications. In this study, a multiomics workflow was designed to combine several publicly available dat...
DNA Methylation as Drug Sensitivity Marker in RCC: A Systematic Review [0.03%]
肾癌中DNA甲基化作为药物敏感性标志物的系统评价
Antonios Koudonas,Georgios Dimitriadis,Anastasios Anastasiadis et al.
Antonios Koudonas et al.
Patient response after treatment of renal cell cancer (RCC) with systemic agents, which include various drug categories, is generally poor and unpredictable. In this context, the ideal drug administration includes tools to predict the sensi...
Soren Impey,Jacob Raber
Soren Impey
The response of the brain to radiation is important for cancer patients receiving whole or partial brain irradiation or total body irradiation, those exposed to irradiation as part of a nuclear accident or a nuclear war or terrorism event, ...
Ahhyun Kim,Claudia A Benavente
Ahhyun Kim
Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is an essential protein involved in the maintenance of repressive epigenetic marks, ensuring epigenetic stability and fidelity. As an epigenetic regulator, UHRF1 comprises several fu...
Isaiah K Mensah,Humaira Gowher
Isaiah K Mensah
The heart is the first organ formed during mammalian development and functions to distribute nutrients and oxygen to other parts of the developing embryo. Cardiomyocytes are the major cell types of the heart and provide both structural supp...
DNA Hypomethylation Underlies Epigenetic Swapping between AGO1 and AGO1-V2 Isoforms in Tumors [0.03%]
DNA低甲基化使AGO1和AGO1-V2异构体在肿瘤中发生表观遗传转换
Jean S Fain,Camille Wangermez,Axelle Loriot et al.
Jean S Fain et al.
Human tumors progress in part by accumulating epigenetic alterations, which include gains and losses of DNA methylation in different parts of the cancer cell genome. Recent work has revealed a link between these two opposite alterations by ...