Isothiocyanates Enhance the Anti-Melanoma Effect of Zebularine Through Modulation of Apoptosis and Regulation of DNMTs' Expression, Chromatin Configuration and Histone Posttranslational Modifications Associated with Altered Gene Expression Patterns [0.03%]
异硫氰酸酯通过调节 apoptosis 和影响基因表达模式相关的 DNMTs 的表达，染色质构型和组蛋白翻译后修饰来增强塞巴列丁对黑素瘤的抑制作用
Ioannis Anestopoulos,Ioannis Paraskevaidis,Sotiris Kyriakou et al.
Ioannis Anestopoulos et al.
Background: In the present study, we aimed to characterize the cytotoxic efficacy of Zebularine either as a single agent or in combination with various isothiocyanates in an in vitro model consisting of human melanoma (A375, Colo-679) as we...
Novel Epigenetics Control (EpC) Nanocarrier for Cancer Therapy Through Dual-Targeting Approach to DNA Methyltransferase and Ten-Eleven Translocation Enzymes [0.03%]
用于癌症治疗的新型表观遗传调控(EpC)纳米载体通过双重靶向方法针对DNA甲基转移酶和Ten-Eleven易位酶
Risa Mitsuhashi,Kiyoshi Sato,Hiroyoshi Kawakami
Risa Mitsuhashi
Background/objectives: Aberrant hypermethylation in the promoter regions of tumor suppressor genes facilitates the pathogenesis and progression of cancer. Therefore, inhibitors targeting DNA methyltransferase (DNMT) have ...
Epigenomic Echoes-Decoding Genomic and Epigenetic Instability to Distinguish Lung Cancer Types and Predict Relapse [0.03%]
表观基因组的回声—解析基因组和表观遗传不稳定以区分肺癌类型和预测复发
Alexandra A Baumann,Zholdas Buribayev,Olaf Wolkenhauer et al.
Alexandra A Baumann et al.
Genomic and epigenomic instability are defining features of cancer, driving tumor progression, heterogeneity, and therapeutic resistance. Central to this process are epigenetic echoes, persistent and dynamic modifications in DNA methylation...
Single-Molecule Nanopore Sequencing of the CpG Island from the Promoter of O6-Methylguanine-DNA Methyltransferase Provides Insights into the Mechanism of De Novo Methylation of G/C-Rich Regions [0.03%]
O6-甲基鸟嘌呤-DNA甲基转移酶启动子的CpG岛的单分子纳米孔测序为富含G/C区域的从头甲基化机制提供了洞见
Alexander V Sergeev,Daniil P Malyshev,Adelya I Genatullina et al.
Alexander V Sergeev et al.
Background: The methylation of cytosine residues at CpG sites within the O6-methylguanine-DNA methyltransferase (MGMT) promoter is a key biomarker in glioblastoma therapy. The MGMT promoter (MGMTp) contains multiple guani...
Iasonas Dermitzakis,Stella Aikaterini Kyriakoudi,Sofia Chatzianagnosti et al.
Iasonas Dermitzakis et al.
The skin, the largest organ of the human body, plays numerous essential roles, including protection against environmental hazards and the regulation of body temperature. The processes of skin homeostasis and ageing are complex and influence...
DNA and RNA Methylation in Rheumatoid Arthritis-A Narrative Review [0.03%]
DNA和RNA甲基化与类风湿性关节炎的关系：综述性文章
Kajetan Kiełbowski,Estera Bakinowska,Anna Gorący-Rosik et al.
Kajetan Kiełbowski et al.
Rheumatoid arthritis (RA) is a progressive autoimmune disease leading to structural and functional joint damage and, eventually, to physical disability. The pathogenesis of the disease is highly complex and involves interactions between fib...
Two Clinically Implementable Digital PCR Assessments of DNA Methylation for Diagnosing Heavy Alcohol Consumption [0.03%]
两种可在临床实施的用于诊断重度饮酒的数字pcrdna甲基化评估方法
Robert Philibert,Steven R H Beach,Allan M Andersen
Robert Philibert
Background: Heavy alcohol consumption (HAC) has a profound adverse effect on human health. Unfortunately, there is a relative lack of tools that are easily implementable in clinical settings and that can be used to supple...
Epigenome-Wide and Methylation Risk Score Analysis of Body Mass Index Among People with HIV [0.03%]
BMI与HIV患者表观基因组和甲基化风险评分的广泛分析
Nanzha Abi,Alexandra Young,Pradeep Tiwari et al.
Nanzha Abi et al.
Background/Objectives: People with HIV (PWH) on antiretroviral therapy (ART) often gain weight, which increases their risk of type 2 diabetes and cardiovascular disease. The role of DNA methylation (DNAm) markers in obesity among PWH is und...
DNA Imprinting and Differentially Expressed Genes in Longissimus thoracis Muscle of Bos indicus Submitted to Early Weaning Management [0.03%]
布拉罕牛早期断奶管理对长肌纤维基因印记及差异表达基因的影响研究
Gustavo Tinoco,Gustavo Russo,Rogério Curi et al.
Gustavo Tinoco et al.
Background/Objectives: Early weaning management followed by energy supplementation can lead to metabolic alterations in the calf that exert long-term effects on the animal's health and performance. It is believed that the main molecular bas...
Environmental Factor Index (EFI): A Novel Approach to Measure the Strength of Environmental Influence on DNA Methylation in Identical Twins [0.03%]
环境因素指数(EIF)：衡量环境对单卵双胞胎DNA甲基化影响的新方法
Yoichi Takenaka,Osaka Twin Research Group,Mikio Watanabe
Yoichi Takenaka
Background/objectives: The dynamic interaction between genomic DNA, epigenetic modifications, and phenotypic traits was examined in identical twins. Environmental perturbations can induce epigenetic changes in DNA methyla...