Targeting the Kynureninase-HDAC6-Complement Axis as a Novel Therapeutic Strategy in Glioblastoma [0.03%]
靶向犬尿酸酶-HDAC6-补体轴作为胶质母细胞瘤的新型治疗策略
Arif Ul Hasan,Sachiko Sato,Mami Obara et al.
Arif Ul Hasan et al.
Background/Objectives: Glioblastoma (GBM) is an aggressive brain tumor known for its profound heterogeneity and treatment resistance. Dysregulated complement signaling and epigenetic alterations have been implicated in GBM progression. This...
Epigenomic Interactions Between Chronic Pain and Recurrent Pressure Injuries After Spinal Cord Injury [0.03%]
脊髓损伤后慢性疼痛与反复性压力伤的表观基因组相互作用
Letitia Y Graves,Melissa R Alcorn,E Ricky Chan et al.
Letitia Y Graves et al.
Background/objectives: This study investigated variations in DNA methylation patterns associated with chronic pain and propensity for recurrent pressure injuries (PrI) in persons with spinal cord injury (SCI). ...
Elena-Cristina Găitănaru,Roua Gabriela Popescu,Andreea-Angelica Stroe et al.
Elena-Cristina Găitănaru et al.
Background/Objectives: Advances in nanopore sequencing have opened new avenues for studying DNA methylation at single-base resolution, yet their application in epigenetic ageing research remains underdeveloped. Methods: We present a novel f...
Trends in DNA Methylation over Time Between Parous and Nulliparous Young Women [0.03%]
初产与未产妇年轻女性间DNA甲基化随时间变化的趋势
Su Chen,John W Holloway,Wilfried Karmaus et al.
Su Chen et al.
Background/objectives: The experience of pregnancy and parturition has been associated with long-term health effects in mothers, imparting protective effects against some diseases while the risk of other diseases is incre...
The Fundamental Role of Nutrients for Metabolic Balance and Epigenome Integrity Maintenance [0.03%]
营养物质在代谢平衡和表观基因组完整性维持中的基本作用
Ana Paula de Souza,Vitor Marinho,Marcelo Rocha Marques
Ana Paula de Souza
Epigenetic modifications act as crucial regulators of gene activity and are influenced by both internal and external environmental factors, with diet being the most impactful external factor. On the other hand, cellular metabolism encompass...
Methylation of the Glucocorticoid Receptor Gene in Children with Somatic Symptom Disorder: A Case-Control Study [0.03%]
儿童躯体症状障碍的糖皮质激素受体基因甲基化研究：病例对照研究
Kyoko Hatta,Masato Kantake,Kyoko Tanaka et al.
Kyoko Hatta et al.
Background: Somatic symptom disorder (SSD) in children may be influenced by stress reactivity and psychosocial factors. The glucocorticoid receptor (GR), encoded by NR3C1, is a key mediator of stress responses. However, the relationship bet...
The Dynamic Interactions of m6A Modification and R-Loops: Implications for Genome Stability [0.03%]
m6A修饰与R-loop的动态互作及其对基因组稳定性的调控作用
Nicholas Kim,Hong Sun
Nicholas Kim
R-loops, three-stranded RNA-DNA hybrid nucleic acid structures, are recognized for their roles in both physiological and pathological processes. Regulation of R-loops is critical for genome stability as disruption of R-loop homeostasis can ...
Epigenetic Insights into Tuberous Sclerosis Complex, Von Hippel-Lindau Syndrome, and Ataxia-Telangiectasia [0.03%]
表观遗传学视野下的结节性硬化症、von Hippel-Lindau 病和共济失调毛细血管扩张症
Gavriel Hadjigavriel,Christina Stylianides,Evangelos Axarloglou et al.
Gavriel Hadjigavriel et al.
Neurocutaneous syndromes represent a clinically and genetically heterogeneous group of disorders, with tuberous sclerosis complex (TSC), von Hippel-Lindau syndrome (VHL), and ataxia-telangiectasia (A-T) exemplifying some of the most complex...
Elena Pozdysheva,Vitaly Korchagin,Tatiana Rumyantseva et al.
Elena Pozdysheva et al.
Background: To date, there are no precise clinical and laboratory methods to accurately predict the onset of fertility decline in women, with chronological age being the ultimate predictor. This has led to increased inter...
Himani Vaidya,Jaroslav Jelinek,Jean-Pierre J Issa
Himani Vaidya
Aging and cancer, though distinct biological processes, share overlapping molecular pathways, particularly in epigenetic regulation. Among these, DNA methylation is central to mediating gene expression, maintaining cellular identity, and re...