Simplified MethylRAD Sequencing to Detect Changes in DNA Methylation at Enhancer Elements in Differentiating Embryonic Stem Cells [0.03%]
简化甲基化RAD测序检测分化胚胎干细胞中增强子元件DNA甲基化的改变
Debapriya Saha,Allison B Norvil,Nadia A Lanman et al.
Debapriya Saha et al.
Differential DNA methylation is characteristic of gene regulatory regions, such as enhancers, which mostly constitute low or intermediate CpG content in their DNA sequence. Consequently, quantification of changes in DNA methylation at these...
Ultra-Low DNA Input into Whole Genome Methylation Assays and Detection of Oncogenic Methylation and Copy Number Variants in Circulating Tumour DNA [0.03%]
超低DNA输入全基因组甲基化测定及循环肿瘤DNA中致癌甲基化和拷贝数变异的检测
Celina Whalley,Karl Payne,Enric Domingo et al.
Celina Whalley et al.
Abnormal CpG methylation in cancer is ubiquitous and generally detected in tumour specimens using a variety of techniques at a resolution encompassing single CpG loci to genome wide coverage. Analysis of samples with very low DNA inputs, su...
Ultra-Low DNA Input into Whole Genome Methylation Assays and Detection of Oncogenic Methylation and Copy Number Variants in Circulating Tumour DNA [0.03%]
超低DNA输入全基因组甲基化测定及循环肿瘤DNA中致癌甲基化和拷贝数变异的检测
Celina Whalley,Karl Payne,Enric Domingo et al.
Celina Whalley et al.
Abnormal CpG methylation in cancer is ubiquitous and generally detected in tumour specimens using a variety of techniques at a resolution encompassing single CpG loci to genome wide coverage. Analysis of samples with very low DNA inputs, su...
Tanner Wright,Yalong Wang,Mark T Bedford
Tanner Wright
Arginine methylation is an essential post-translational modification (PTM) deposited by protein arginine methyltransferases (PRMTs) and recognized by Tudor domain-containing proteins. Of the nine mammalian PRMTs, PRMT5 is the primary enzyme...
Valery Filippov,Karen Jaceldo-Siegl,Alexey Eroshkin et al.
Valery Filippov et al.
Epigenetic studies in animal models have demonstrated that diet affects gene regulation by altering methylation patterns. We interrogated methylomes in humans who have different sources of protein in their diet. We compared methylation of D...
The Roles of the Histone Protein Modifier EZH2 in the Uterus and Placenta [0.03%]
EZH2组蛋白修饰酶在子宫和胎盘的作用
Ana M Mesa,Cheryl S Rosenfeld,Geetu Tuteja et al.
Ana M Mesa et al.
Epigenetic modifications regulate normal physiological, as well as pathological processes in various organs, including the uterus and placenta. Both organs undergo dramatic and rapid restructuring that depends upon precise orchestration of ...
Murat Toruner,Martin E Fernandez-Zapico,Christopher L Pin
Murat Toruner
Pancreatic cancer remains among the deadliest forms of cancer with a 5 year survival rate less than 10%. With increasing numbers being observed, there is an urgent need to elucidate the pathogenesis of pancreatic cancer. While both contribu...
Epigenetic Dynamics of the Infant Immune System Reveals a Tumor Necrosis Factor Superfamily Signature in Early Human Life [0.03%]
婴儿免疫系统的表观遗传动力学揭示了早期人类生命的肿瘤坏死因子超家族特征
Maria J Gutierrez,Gustavo Nino,Xiumei Hong et al.
Maria J Gutierrez et al.
DNA methylation (DNAm) is an essential mechanism governing normal development in humans. Although most DNAm patterns in blood cells are established in utero, the genes associated with immune function undergo postnatal DNAm modifications, an...
Molecular and Epigenetic Mechanisms Underlying Cognitive and Adaptive Responses to Stress [0.03%]
应激下的认知和适应性反应的分子及表观遗传机制
Alexandra F Trollope,Karen R Mifsud,Emily A Saunderson et al.
Alexandra F Trollope et al.
Consolidation of contextual memories after a stressful encounter is essential for the survival of an organism and in allowing a more appropriate response to be elicited should the perceived threat reoccur. Recent evidence has explored the c...
Nuclear Envelope Regulation of Oncogenic Processes: Roles in Pancreatic Cancer [0.03%]
细胞核膜对致癌过程的调节在胰腺癌中的作用
Claudia C Preston,Randolph S Faustino
Claudia C Preston
Pancreatic cancer is an aggressive and intractable malignancy with high mortality. This is due in part to a high resistance to chemotherapeutics and radiation treatment conferred by diverse regulatory mechanisms. Among these, constituents o...