5-Methylcytosine and 5-Hydroxymethylcytosine Signatures Underlying Pediatric Cancers [0.03%]
儿童肿瘤中的5-甲基胞嘧啶和5-羟甲基胞嘧啶特征(signature)
Shalu Jhanwar,Ajinkya Deogade
Shalu Jhanwar
In addition to the genetic variations, recent evidence has shown that DNA methylation of both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) underlies the pathogenesis of pediatric cancer. Given the high mortality rate, there is ...
Editorial
Epigenomes. 2019 May 9;3(2):9. DOI:10.3390/epigenomes3020009 2019
Bonnie Cantrell,Hannah Lachance,Brenda Murdoch et al.
Bonnie Cantrell et al.
To elucidate the extent to which DNA methylation varies across multiple tissues in the brain and between animals, we have quantified global DNA methylation in tissues comprising the limbic system for six Red Angus x Simmental steers. Global...
A Brief Overview of lncRNAs in Endothelial Dysfunction-Associated Diseases: From Discovery to Characterization [0.03%]
内皮细胞功能障碍相关疾病中的长链非编码RNA研究进展：从发现到表征
Rashidul Islam,Christopher Lai
Rashidul Islam
Long non-coding RNAs (lncRNAs) are a novel class of regulatory RNA molecules and they are involved in many biological processes and disease developments. Several unique features of lncRNAs have been identified, such as tissue-and/or cell-sp...
Martijn R H Zwinderman,Sander de Weerd,Frank J Dekker
Martijn R H Zwinderman
Around three million patients die due to airway inflammatory diseases each year. The most notable of these diseases are asthma and chronic obstructive pulmonary disease (COPD). Therefore, new therapies are urgently needed. Promising targets...
Behavioral Epigenetics: Perspectives Based on Experience-Dependent Epigenetic Inheritance [0.03%]
基于体验依赖的表观遗传学继承的行为表观遗传学研究观点
You-Yuan Pang,Rita Jui-Hsien Lu,Pao-Yang Chen
You-Yuan Pang
Epigenetic regulation plays an important role in gene regulation, and epigenetic markers such as DNA methylation and histone modifications are generally described as switches that regulate gene expression. Behavioral epigenetics is defined ...
Epigenetic Modifications in Generalized Autoimmune Epithelitis: Sjögren's Syndrome and Primary Biliary Cholangitis [0.03%]
原发性免疫性 epithelitis 的表观遗传修饰：Sjogren 综合征和原发性胆汁性肝硬化
Pinelopi Arvaniti,Kalliopi Zachou,Aggeliki Lyberopoulou et al.
Pinelopi Arvaniti et al.
Sjögren's syndrome (SjS) and primary biliary cholangitis (PBC) can be classified as a model of generalized autoimmune epithelitis based on their frequent coexistence in clinical practice and the highly specific immune mediated injury of ta...
Alessandro Fiorenzano,Emilia Pascale,Eduardo Jorge Patriarca et al.
Alessandro Fiorenzano et al.
The power of embryonic stem cells (ESCs) lies in their ability to self-renew and differentiate. Behind these two unique capabilities is a fine-tuned molecular network that shapes the genetic, epigenetic, and epitranscriptomic ESC plasticity...
Cristina D&#x;Aniello,Federica Cermola,Eduardo J Patriarca et al.
Cristina D&#x;Aniello et al.
Cell state transition (CST) occurs during embryo development and in adult life in response to different stimuli and is associated with extensive epigenetic remodeling. Beyond growth factors and signaling pathways, increasing evidence point ...
Jessica L Flesher,David E Fisher
Jessica L Flesher
Epigenetic regulation is a crucial component of DNA maintenance and cellular identity. As our understanding of the vast array of proteins that contribute to chromatin accessibility has advanced, the role of epigenetic remodelers in disease ...
The Dynamic Partnership of Polycomb and Trithorax in Brain Development and Diseases [0.03%]
Polycomb和Trithorax在大脑发育及疾病中的动态互作关系
Janise N Kuehner,Bing Yao
Janise N Kuehner
Epigenetic mechanisms, including DNA and histone modifications, are pivotal for normal brain development and functions by modulating spatial and temporal gene expression. Dysregulation of the epigenetic machinery can serve as a causal role ...