W Aline Ingelson-Filpula,Kenneth B Storey
W Aline Ingelson-Filpula
The winter months are challenging for many animal species, which often enter a state of dormancy or hypometabolism to "wait out" the cold weather, food scarcity, reduced daylight, and restricted mobility that can characterize the season. To...
Epigenetic Immune Remodeling of Mesothelioma Cells: A New Strategy to Improve the Efficacy of Immunotherapy [0.03%]
免疫细胞的表观遗传重编程：提高免疫疗法疗效的新策略
Maria Fortunata Lofiego,Sara Cannito,Carolina Fazio et al.
Maria Fortunata Lofiego et al.
Malignant pleural mesothelioma (MPM) is an aggressive malignancy with a severe prognosis, and with a long-standing need for more effective therapeutic approaches. However, treatment with immune checkpoint inhibitors is becoming an increasin...
The Histone H3 K4me3, K27me3, and K27ac Genome-Wide Distributions Are Differently Influenced by Sex in Brain Cortexes and Gastrocnemius of the Alzheimer's Disease PSAPP Mouse Model [0.03%]
阿尔茨海默病PSAPP小鼠模型脑皮层和腓肠肌染色体组蛋白H3 K4me3，K27me3和K27ac全基因组分布受性别影响不同
Francesca Casciaro,Giuseppe Persico,Martina Rusin et al.
Francesca Casciaro et al.
Background: Women represent the majority of Alzheimer's disease patients and show typical symptoms. Genetic, hormonal, and behavioral mechanisms have been proposed to explain sex differences in dementia prevalence. Howeve...
Vladimir Brukhin,Emidio Albertini
Vladimir Brukhin
Plants are exposed to highly fluctuating effects of light, temperature, weather conditions, and many other environmental factors throughout their life. As sessile organisms, unlike animals, they are unable to escape, hide, or even change th...
The Regulation of Plant Vegetative Phase Transition and Rejuvenation: miRNAs, a Key Regulator [0.03%]
植物营养生长阶段转换和返老还童的调控：miRNA——关键因子
Tajbir Raihan,Robert L Geneve,Sharyn E Perry et al.
Tajbir Raihan et al.
In contrast to animals, adult organs in plants are not formed during embryogenesis but generated from meristematic cells as plants advance through development. Plant development involves a succession of different phenotypic stages and the t...
One Omics Approach Does Not Rule Them All: The Metabolome and the Epigenome Join Forces in Haematological Malignancies [0.03%]
单模态组学不足以解释血液系统恶性肿瘤的表观遗传与代谢特征及其临床意义：多组学联合分析揭示调控新机制
Antonia Kalushkova,Patrick Nylund,Alba Atienza Párraga et al.
Antonia Kalushkova et al.
Aberrant DNA methylation, dysregulation of chromatin-modifying enzymes, and microRNAs (miRNAs) play a crucial role in haematological malignancies. These epimutations, with an impact on chromatin accessibility and transcriptional output, are...
Shailendra S Maurya
Shailendra S Maurya
Enhancers are cis-regulatory elements containing short DNA sequences that serve as binding sites for pioneer/regulatory transcription factors, thus orchestrating the regulation of genes critical for lineage determination. The activity of en...
Joyce K Thompson,Filip Bednar
Joyce K Thompson
Pancreatic cancer is a molecularly heterogeneous disease. Epigenetic changes and epigenetic regulatory mechanisms underlie at least some of this heterogeneity and contribute to the evolution of aggressive tumor biology in patients and the t...
Exploring DNA Methylation Diversity in the Honey Bee Brain by Ultra-Deep Amplicon Sequencing [0.03%]
通过超深扩增子测序在蜜蜂大脑中探索DNA甲基化多样性
Robert Kucharski,Ryszard Maleszka
Robert Kucharski
Understanding methylation dynamics in organs or tissues containing many different cell types is a challenging task that cannot be efficiently addressed by the low-depth bisulphite sequencing of DNA extracted from such sources. Here we explo...
Promoter and Terminator Optimization for DNA Methylation Targeting in Arabidopsis [0.03%]
拟南芥DNA甲基化靶向的启动子和终止子优化
Jason Gardiner,Jenny M Zhao,Kendall Chaffin et al.
Jason Gardiner et al.
DNA methylation is an important epigenetic mark involved in gene regulation and silencing of transposable elements. The presence or absence of DNA methylation at specific sites can influence nearby gene expression and cause phenotypic chang...