Sustained Higher Levels of Plasma hsa-miR-17-5p Expression During Gestational Diabetes Mellitus and Postpartum [0.03%]
妊娠期糖尿病患者血浆hsa-miR-17-5p高水平表达的持续性研究
Arathi Pillai,Sibin M Kandi,Nidhi Tripathy et al.
Arathi Pillai et al.
Background: The role of circulatory miRNAs in gestational diabetes mellitus (GDM) was explored extensively in previous studies. However, there was limited literature on longitudinal studies exploring the changes in miRNA expression during p...
m6A RNA Methylation in Psychiatric Disorders: An Emerging Epitranscriptomic Axis [0.03%]
精神疾病中的m6A RNA甲基化：新兴的表转录组轴线
Ambrose Loc Ngo,Linda Nguyen,Niki Gharavi Alkhansari et al.
Ambrose Loc Ngo et al.
N6-methyladenosine (m6A) is the most prevalent internal modification in eukaryotic messenger RNA (mRNA) and plays a vital role in post-transcriptional gene regulation. In recent years, m6A has emerged as a pivotal epitranscriptomic signal i...
Comparative Mapping of N6-Methyladenine, C5-Methylcytosine, and C5-Hydroxymethylcytosine in a Single Species Reveals Constitutive, Somatic- and Germline-Specific, and Age-Related Genomic Context Distributions and Biological Functions [0.03%]
N6-甲基腺嘌呤、C5-甲基胞嘧啶和C5-羟甲基胞嘧啶在同一物种中的比较图谱揭示了基因组背景分布与生物功能的组成型、体细胞及生殖细胞特异型以及年龄相关性
Thibaut Renard,Serge Aron
Thibaut Renard
Background/objectives: The DNA methylome allows environmental signals to be converted into stable and adaptive changes in gene expression. While 5-methylcytosine (5mC) has been extensively studied, alternative epigenetic ...
Deciphering the Heterogeneity of Pancreatic Cancer: DNA Methylation-Based Cell Type Deconvolution Unveils Distinct Subgroups and Immune Landscapes [0.03%]
破解胰腺癌的异质性：基于DNA甲基化的细胞类型解卷积揭示了不同的亚组和免疫图谱
Barbara Mitsuyasu Barbosa,Alexandre Todorovic Fabro,Roberto da Silva Gomes et al.
Barbara Mitsuyasu Barbosa et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly heterogeneous malignancy, characterized by low tumor cellularity, a dense stromal response, and intricate cellular and molecular interactions within the tumor microenvironment ...
Yalong Wang
Yalong Wang
The innate immune system protects against infection and cellular damage by recognizing conserved pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Emerging evidence suggests that aberrant epige...
An Epigenomic Meta-Analysis of Differentially Methylated Sites in Pre- and Post-Metabolic/Bariatric Surgery Adult Female Patients [0.03%]
代谢和减肥手术前后成人女性差异甲基化位点的表观基因组元分析
Agnieszka Lovett,Graham A Hitman,Georgios K Dimitriadis et al.
Agnieszka Lovett et al.
Background/objectives: Metabolic/bariatric surgery is currently the most successful treatment for patients with obesity; however, a fifth of patients undergoing surgery may not lose enough weight to be considered successf...
Dynamics and Malleability of Plant DNA Methylation During Abiotic Stresses [0.03%]
植物在非生物胁迫过程中DNA甲基化的动态变化及可塑性
Niraj Lodhi,Rakesh Srivastava
Niraj Lodhi
Epigenetic regulation, particularly DNA methylation, plays a crucial role in plant adaptation to environmental stresses by modulating gene expression without altering the underlying DNA sequence. In response to major abiotic stresses such a...
Christina Stylianides,Gavriel Hadjigavriel,Paschalis Theotokis et al.
Christina Stylianides et al.
Neurocutaneous syndromes, known as phakomatoses, encompass a diverse group of congenital conditions affecting the nervous system and skin, with neurofibromatosis type 1 (NF1) and neurofibromatosis type 2 (NF2) among the most clinically sign...
Role of Ionizing Radiation in Shaping the Complex Multi-Layered Epigenome [0.03%]
电离辐射在塑造复杂多层表观基因组中的作用
Claudia E Rübe,Mutaz A Abd Al-Razaq,Carola Meier et al.
Claudia E Rübe et al.
The impact of ionizing radiation (IR) with induction of various DNA damage is based not only on genetic but also on epigenetic effects. Epigenetic modifications determine the chromatin structure and DNA accessibility, thereby regulating cel...
DNA Methylation Status of Regulatory Regions of Apoptosis-Associated Genes in Dystropy «Huntington's Disease-Non-Small Cell Lung Cancer» [0.03%]
凋亡相关基因调控区域的DNA甲基化状态「亨廷顿舞蹈病-非小细胞肺癌」
Nadezhda P Babushkina,Elena Yu Bragina,Densema E Gomboeva et al.
Nadezhda P Babushkina et al.
Background. Studies of comorbid (syntropic) and inversely comorbid (rarely occurring together, i.e., dystropic) diseases have focused on the search for molecular causes of this phenomenon. Materials. We investigated DNA methylation levels i...