Louis Tirot,Pauline E Jullien,Mathieu Ingouff
Louis Tirot
Cytosine methylation is an epigenetic mark present in most eukaryotic genomes that contributes to the regulation of gene expression and the maintenance of genome stability. DNA methylation mostly occurs at CG sequences, where it is initiall...
Epigenetic Analyses of Alcohol Consumption in Combustible and Non-Combustible Nicotine Product Users [0.03%]
可燃和非可燃尼古丁产品使用者的饮酒表观遗传分析
Kelsey Dawes,Luke Sampson,Rachel Reimer et al.
Kelsey Dawes et al.
Alcohol and tobacco use are highly comorbid and exacerbate the associated morbidity and mortality of either substance alone. However, the relationship of alcohol consumption to the various forms of nicotine-containing products is not well u...
Deciphering Plant Chromatin Regulation via CRISPR/dCas9-Based Epigenome Engineering [0.03%]
基于CRISPR / dCas9的表观基因组工程解析植物染色质调控元件
Annick Dubois,François Roudier
Annick Dubois
CRISPR-based epigenome editing uses dCas9 as a platform to recruit transcription or chromatin regulators at chosen loci. Despite recent and ongoing advances, the full potential of these approaches to studying chromatin functions in vivo rem...
Can Immune Suppression and Epigenome Regulation in Placenta Offer Novel Insights into Cancer Immune Evasion and Immunotherapy Resistance? [0.03%]
胎盘免疫抑制和表观基因调控能为揭示癌细胞的免疫逃逸及免疫治疗抗性提供新见解吗？
Sultana Mehbuba Hossain,Chiemi F Lynch-Sutherland,Aniruddha Chatterjee et al.
Sultana Mehbuba Hossain et al.
Cancer is the second leading cause of mortality and morbidity in the developed world. Cancer progression involves genetic and epigenetic alterations, accompanied by aggressive changes, such as increased immune evasion, onset of metastasis, ...
Combinatorial Epigenetic and Immunotherapy in Breast Cancer Management: A Literature Review [0.03%]
乳腺癌管理中表观遗传学和免疫治疗的联合应用：文献回顾
Yu-Ting Lee,Yu-Ming Chuang,Michael W Y Chan
Yu-Ting Lee
Breast cancer is one of the leading causes of death among cancer patients worldwide. To date, there are several drugs that have been developed for breast cancer therapy. In the 21st century, immunotherapy is considered a pioneering method f...
Interplay between DNA and RNA Modifications: A Constantly Evolving Process [0.03%]
DNA和RNA修饰的相互作用：一个不断发展的过程
Annalisa Fico,Luciano Di Croce,Maria R Matarazzo
Annalisa Fico
The epigenome refers to the entirety of DNA methylations, histone modifications, nucleosome occupancy, and coding and non-coding RNAs (and their modifications) in different cell types [...].
Vijay Gahlaut,Gaurav Zinta,Vandana Jaiswal et al.
Vijay Gahlaut et al.
Plant breeding conventionally depends on genetic variability available in a species to improve a particular trait in the crop. However, epigenetic diversity may provide an additional tier of variation. The recent advent of epigenome technol...
UV Radiation and Its Relation to DNA Methylation in Epidermal Cells: A Review [0.03%]
紫外线辐射与表皮细胞DNA甲基化关系的研究进展综述
Naila Francis Paulo de Oliveira,Beatriz Fernandes de Souza,Marina de Castro Coêlho
Naila Francis Paulo de Oliveira
DNA methylation is the most studied epigenetic mark, and it can be altered by environmental factors. Among these factors, ultraviolet radiation (UV) is little explored within this context. While the relationship between UV radiation and DNA...
The Contribution of Epigenetic Inheritance Processes on Age-Related Cognitive Decline and Alzheimer's Disease [0.03%]
表观遗传继承过程在年龄相关性认知衰退及阿尔茨海默病中的作用
Aina Bellver-Sanchis,Mercè Pallàs,Christian Griñán-Ferré
Aina Bellver-Sanchis
During the last years, epigenetic processes have emerged as important factors for many neurodegenerative diseases, such as Alzheimer's disease (AD). These complex diseases seem to have a heritable component; however, genome-wide association...
Chia-Ling Hsu,Yi-Chen Lo,Cheng-Fu Kao
Chia-Ling Hsu
During the process of aging, extensive epigenetic alterations are made in response to both exogenous and endogenous stimuli. Here, we summarize the current state of knowledge regarding one such alteration, H3K4 methylation (H3K4me), as it r...