Methylation Status of Exon IV of the Brain-Derived Neurotrophic Factor (BDNF)-Encoding Gene in Patients with Non-Diabetic Hyperglycaemia (NDH) before and after a Lifestyle Intervention [0.03%]
非糖尿病高血糖患者的生活方式干预前后脑源性神经营养因子（BDNF）基因的第IV外显子甲基化状态研究
Helene A Fachim,Nagaraj Malipatil,Kirk Siddals et al.
Helene A Fachim et al.
BDNF signalling in hypothalamic neuronal circuits is thought to regulate mammalian food intake. In light of this, we investigated how a lifestyle intervention influenced serum levels and DNA methylation of BDNF gene in fat tissue and buffy ...
Opportunities for Early Cancer Detection: The Rise of ctDNA Methylation-Based Pan-Cancer Screening Technologies [0.03%]
基于ctDNA甲基化的泛癌早筛技术发展机遇与挑战
Nicolas Constantin,Abu Ali Ibn Sina,Darren Korbie et al.
Nicolas Constantin et al.
The efficiency of conventional screening programs to identify early-stage malignancies can be limited by the low number of cancers recommended for screening as well as the high cumulative false-positive rate, and associated iatrogenic burde...
Emily M Dennis,David M Garcia
Emily M Dennis
Prions are proteins that can stably fold into alternative structures that frequently alter their activities. They can self-template their alternate structures and are inherited across cell divisions and generations. While they have been stu...
Kenneth C Ehrlich,Hong-Wen Deng,Melanie Ehrlich
Kenneth C Ehrlich
Striated muscle has especially large energy demands. We identified 97 genes preferentially expressed in skeletal muscle and heart, but not in aorta, and found significant enrichment for mitochondrial associations among them. We compared the...
Mallika Vijayanathan,María Guadalupe Trejo-Arellano,Iva Mozgová
Mallika Vijayanathan
Polycomb repressive complex 2 (PRC2) represents a group of evolutionarily conserved multi-subunit complexes that repress gene transcription by introducing trimethylation of lysine 27 on histone 3 (H3K27me3). PRC2 activity is of key importan...
Yasushi Hiraoka
Yasushi Hiraoka
Chromatin is a fundamental and highly conserved structure that carries genetic and epigenetic information in eukaryotic cells [...].
Editorial
Epigenomes. 2022 Jan 2;6(1):2. DOI:10.3390/epigenomes6010002 2022
Victoria Sarne,Sandrina Braunmueller,Lisa Rakob et al.
Victoria Sarne et al.
Tumorigenesis as well as the molecular orchestration of cancer progression are very complex mechanisms that comprise numerous elements of influence and regulation. Today, many of the major concepts are well described and a basic understandi...
Epigenetic Regulation of EMT (Epithelial to Mesenchymal Transition) and Tumor Aggressiveness: A View on Paradoxical Roles of KDM6B and EZH2 [0.03%]
KDM6B和EZH2在上皮间质转化及肿瘤侵袭性中的作用及表观遗传调控机制：冰与火之歌？
Camille Lachat,Michaël Boyer-Guittaut,Paul Peixoto et al.
Camille Lachat et al.
EMT (epithelial to mesenchymal transition) is a plastic phenomenon involved in metastasis formation. Its plasticity is conferred in a great part by its epigenetic regulation. It has been reported that the trimethylation of lysine 27 histone...
Uncovering Differentially Methylated Regions (DMRs) in a Salt-Tolerant Rice Variety under Stress: One Step towards New Regulatory Regions for Enhanced Salt Tolerance [0.03%]
在盐胁迫下发现耐盐水稻品种中的差异甲基化区域（DMR）：向发现新的调控区域以增强盐度耐受性迈出的一步
Liliana J Ferreira,Mark T A Donoghue,Pedro Barros et al.
Liliana J Ferreira et al.
Chromatin structure, DNA methylation, and histone modifications act in a concerted manner to influence gene expression and therefore plant phenotypes. Environmental stresses are often associated with extensive chromatin rearrangements and m...
Biotic Stress-Induced Priming and De-Priming of Transcriptional Memory in Arabidopsis and Apple [0.03%]
生物胁迫诱导的拟南芥和苹果转录记忆的启动和解除
Kay Gully,Jean-Marc Celton,Alexandre Degrave et al.
Kay Gully et al.
Under natural growth conditions, plants experience various and repetitive biotic and abiotic stresses. Salicylic acid (SA) is a key phytohormone involved in the response to biotic challenges. Application of synthetic SA analogues can effici...