Association of Toll-Like Receptor Gene Polymorphisms with Tuberculosis in HIV-Positive Participants [0.03%]
TLR基因多态性与HIV阳性患者的结核病的关联研究
Svetlana Salamaikina,Vitaly Korchagin,Ekaterina Kulabukhova et al.
Svetlana Salamaikina et al.
Genetic factors in the HIV-background may play a significant role in the susceptibility to secondary diseases, like tuberculosis, which is the leading cause in mortality of HIV-positive people. Toll-like receptors (TLRs) are considered to b...
Epigenetic Regulation in Heterosis and Environmental Stress: The Challenge of Producing Hybrid Epigenomes to Face Climate Change [0.03%]
表观遗传调控在杂种优势和环境胁迫中的作用：应对气候变化的混合表观基因组生产的挑战
Fátima Duarte-Aké,Rosa Us-Camas,Clelia De-la-Peña
Fátima Duarte-Aké
Epigenetic regulation has the potential to revolutionize plant breeding and improve crop yields by regulating gene expression in plants. DNA methylation and histone modifications are key epigenetic modifications that can impact plant develo...
Dylan Wrede,Mika Bordak,Yeabtsega Abraham et al.
Dylan Wrede et al.
Epigenetics generally involves genetic control by factors other than our own DNA sequence. Recent research has focused on delineating the mechanisms of two major epigenetic phenomena: DNA methylation and histone modification. As epigenetics...
Therapeutic Applications of Azanucleoside Analogs as DNA Demethylating Agents [0.03%]
亚核苷类似物作为DNA去甲基化剂的治疗应用
Fallon Gallimore,Tamer E Fandy
Fallon Gallimore
Azanucleosides, such as 5-azacytidine and decitabine, are DNA demethylating agents used in the treatment of acute myeloid leukemia and myelodysplastic syndromes. Researchers continue to explore their utility in the treatment of other hemato...
Graft-Derived Cell-Free DNA Quantification following Liver Transplantation Using Tissue-Specific DNA Methylation and Donor-Specific Genotyping Techniques: An Orthogonal Comparison Study [0.03%]
肝移植后利用组织特异性DNA甲基化和供者特异性基因分型技术测定移植物衍生的无细胞DNA含量：一项正交对比研究
Daniel R A Cox,Tess McClure,Fan Zhang et al.
Daniel R A Cox et al.
Background: Graft-derived cell-free DNA (gdcfDNA) analysis has shown promise as a non-invasive tool for monitoring organ health following solid organ transplantation. A number of gdcfDNA analysis techniques have been described; however, the...
Histone Demethylase Modulation: Epigenetic Strategy to Combat Cancer Progression [0.03%]
表观遗传调控组蛋白去甲基化酶抗肿瘤药物发现及机制研究
Rashmi Srivastava,Rubi Singh,Shaurya Jauhari et al.
Rashmi Srivastava et al.
Epigenetic modifications are heritable, reversible changes in histones or the DNA that control gene functions, being exogenous to the genomic sequence itself. Human diseases, particularly cancer, are frequently connected to epigenetic dysre...
Critical Considerations for Investigating MicroRNAs during Tumorigenesis: A Case Study in Conceptual and Contextual Nuances of miR-211-5p in Melanoma [0.03%]
微小核糖核酸在肿瘤发生过程中的研究需考虑的关键问题：以黑色素瘤中miR-211-5p为例分析概念和语境差异
Fatemeh Vand-Rajabpour,Meghan Savage,Rachel L Belote et al.
Fatemeh Vand-Rajabpour et al.
MicroRNAs are non-coding RNAs fundamental to metazoan development and disease. Although the aberrant regulation of microRNAs during mammalian tumorigenesis is well established, investigations into the contributions of individual microRNAs a...
Epigenome-Wide Changes in the Cell Layers of the Vein Wall When Exposing the Venous Endothelium to Oscillatory Shear Stress [0.03%]
暴露于振荡剪切应力下静脉内皮层对静脉壁各细胞层表观基因组的影响
Mariya A Smetanina,Valeria A Korolenya,Alexander E Kel et al.
Mariya A Smetanina et al.
Epigenomic changes in the venous cells exerted by oscillatory shear stress towards the endothelium may result in consolidation of gene expression alterations upon vein wall remodeling during varicose transformation. We aimed to reveal such ...
Chemical Inhibitors Targeting the Histone Lysine Demethylase Families with Potential for Drug Discovery [0.03%]
表观遗传修饰酶组蛋白赖氨酸去甲基化酶家族的小分子抑制剂及药物研发潜力
Nando Dulal Das,Hideaki Niwa,Takashi Umehara
Nando Dulal Das
The dynamic regulation of histone methylation and demethylation plays an important role in the regulation of gene expression. Aberrant expression of histone lysine demethylases has been implicated in various diseases including intractable c...
Ayoung Kim,Kyumin Mo,Hyeonseok Kwon et al.
Ayoung Kim et al.
Breast cancer remains a common cause of cancer-related death in women. Therefore, further studies are necessary for the comprehension of breast cancer and the revolution of breast cancer treatment. Cancer is a heterogeneous disease that res...