Evaluating the Therapeutic Efficacy of an Anti-BAFF Receptor Antibody Using a Rheumatoid Arthritis Mouse Model [0.03%]
评估抗BAFF受体抗体的治疗效果：采用类风湿关节炎小鼠模型
Adi Aharon,Rachel Birnboim-Perach,Omer Grotto et al.
Adi Aharon et al.
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation that leads to tissue damage and disability. RA affects approximately 0.5-1% of the global population and is driven ...
Enhanced ADCC Activity of a C-Terminal Lysine Variant of an IgG1 Antibody Driven by N-Linked MAN5 Glycan Using a Reporter Gene Assay [0.03%]
用人源MAN5报告基因体系筛选的IgG1抗体C端赖氨酸突变体Fc段增强ADCC活性
Ming-Ching Hsieh,Kristiina Dorofejeva,Jingming Zhang et al.
Ming-Ching Hsieh et al.
Background: Antibody-dependent cellular cytotoxicity (ADCC) is an immune response where antibodies bind to target cells and activate effector cells through Fcγ receptors, ultimately leading to the destruction of the targ...
Modulating Subcellular Localization to Preserve the Stability and Functionality of Intracellular Nanobodies [0.03%]
调节亚细胞定位以保持胞内纳米抗体的稳定性和功能性
Wenli Sun,Keke Huang,Yaping Cheng et al.
Wenli Sun et al.
Background: Antibodies have revolutionized therapeutics and diagnostics, but their applications are largely restricted to extracellular targets due to challenges in intracellular delivery and stability. Nanobodies, with their small size and...
A Robust, High-Titer, Semi-Automated, and In-Culture Antibody-Capturing Transient CHO Platform Technology [0.03%]
一种稳健、高滴度、半自动化的抗体捕获稳定Chinese Hamster Ovary细胞系平台技术
Lauren Gebhardt,Molica Abel,Jing Zhou et al.
Lauren Gebhardt et al.
Background: Recent advances in antibody discovery technologies, especially progress in de novo synthesis through machine learning, have imposed a significant production challenge for the generation of a large diversity of...
Structural and Functional Characterization of Anti-SARS-CoV-2 Spike Monoclonal Antibodies Produced via Bicistronic Expression in CHO Cells [0.03%]
通过CHO细胞双顺反子表达产生的抗SARS-CoV-2刺突单克隆抗体的结构和功能表征
Federico Francisco Marsili,Fernanda Bittencourt de Aquino,Hiam Rodrigo da Silva Arruda et al.
Federico Francisco Marsili et al.
Background: Recombinant monoclonal antibodies (mAbs) represent the fastest-growing sector of the biopharmaceutical industry, with their efficient expression being a key technological factor for scalability. ...
Monoclonal Antibodies Can Aid in the Culture-Based Detection and Differentiation of Mucorales Fungi-The Flesh-Eating Pathogens Apophysomyces and Saksenaea as an Exemplar [0.03%]
单克隆抗体有助于基于培养的检测和鉴别肉食性病原阿포菲斯霉菌和萨克斯纳霉菌属真菌
Christopher R Thornton,Genna E Davies
Christopher R Thornton
Background: The frequency of necrotising cutaneous and soft tissue infections caused by the Mucorales fungi Apophysomyces and Sakasenaea is increasing. The absence of sophisticated diagnostic technologies in low- and midd...
Novel Humanized Anti-HER3 Antibodies: Structural Characterization and Therapeutic Activity [0.03%]
新型人源化抗her3抗体：结构特征及治疗活性
Alessia Muzi,Roberto Arriga,Giovanni Bulfaro et al.
Alessia Muzi et al.
Background/objectives: The ErbB protein family plays a critical role in the progression of various solid tumors, and HER3 has been implicated in resistance mechanisms to multiple cancer therapies due to its ability to for...
Generation Using Phage-Display of pH-Dependent Antibodies Against the Tumor-Associated Antigen AXL [0.03%]
用于肿瘤相关抗原AXL的pH依赖性抗体噬菌体展示及生成研究
Tristan Mangeat,Célestine Mairaville,Myriam Chentouf et al.
Tristan Mangeat et al.
Background/objectives: Tumor-associated antigens are not tumor-specific antigens but proteins that are overexpressed by tumor cells and also weakly expressed at the surface of healthy tissues. Therefore, some side effects...
Edward John Filippone,John L Farber
Edward John Filippone
Primary podocytopathies, including minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS), are caused by a circulating factor or factors injurious to the podocyte. An immunologic origin seems likely based on responsivene...
Purification and Characterization of Immunoglobulin Y (IgY) Targeting Surface Antigen 1 (SAG1) of Toxoplasma gondii [0.03%]
针对弓形虫表面抗原1(SAG1)的免疫球蛋白Y(IgY)的纯化与鉴定
Enrique Adrián Herrera-Aguirre,Diana León-Núñez,Jaime Marcial-Quino et al.
Enrique Adrián Herrera-Aguirre et al.
Toxoplasma gondii (T. gondii) is an obligate intracellular protozoan parasite responsible for toxoplasmosis, a disease with significant health implications for humans and animals. The surface antigen 1 (SAG1) of T. gondii is a major immunod...