Marta Baselga,Javier Sánchez-Prieto,Víctor Manuel Medina Pérez et al.
Marta Baselga et al.
Background/objectives: Single-domain antibodies (sdAbs) are derived from camelid heavy-chain antibodies (HCAb). Their small size, high stability, and ease of production, among other properties, makes them highly valuable ...
Physiologically Based Pharmacokinetic Model for Prediction of Immunoglobulins Exposure in Pregnant Women [0.03%]
基于生理的药代动力学模型预测孕妇免疫球蛋白暴露量
Million A Tegenge
Million A Tegenge
Background: Physiologically based pharmacokinetic (PBPK) modeling is applied to address clinical pharmacology issues including dose selection and exposure assessments for special populations (e.g., pediatrics, and renally or hepatically imp...
Developing a 3D Model Culture of an EBV+/CD30+ B-Anaplastic Large Cell Lymphoma Cell Line to Assay Brentuximab Vedotin Treatment [0.03%]
建立一个B细胞来源的EBER阳性的CD30阳性间变性大细胞淋巴瘤（ALCL）的3D培养模型以检测布伦妥木单抗 vedotin疗效
Paolo Giannoni,Gabriella Pietra,Orlando Izzo et al.
Paolo Giannoni et al.
Background/objectives: Three-dimensional (3D) in vitro cell culture models have recently stimulated great interest since they may have more pre-clinical value than conventional in vitro 2D models. In fact, 3D culture mode...
A Novel FLI1 Monoclonal Antibody Which Recognizes EWS::FLI1 with High Affinity Is Useful for Detecting Ewing Sarcoma [0.03%]
一种新型的FLI1单克隆抗体可高效识别EWS::FLI1，有助于尤因肉瘤检测
Saravana P Selvanathan,Olivia O Lansinger,David V Allegakoen et al.
Saravana P Selvanathan et al.
Background: Ewing sarcoma (ES) is a rare tumor that affects children, adolescents, and young adults. ES is associated with high morbidity in all patients and high mortality for those who present with metastatic disease. A...
CEA-4-1BBL: CEACAM5-Targeted 4-1BB Ligand Fusion Proteins for Cis Co-Stimulation with CEA-TCB [0.03%]
CEACAM5导向的4-1BB配体融合蛋白CEA-4-1BBL与CEA-TCBcis共刺激治疗转移性结直肠癌和其他表达CEA的实体瘤中的I期剂量递增和扩展研究
Christina Claus,Claudia Ferrara-Koller,Johannes Sam et al.
Christina Claus et al.
Background/objectives: T cell bispecific antibodies (TCBs) result in the activation of T cell receptor signaling upon binding to tumor antigens providing signal 1 to T cells. To enhance and sustain their activity, a co-st...
Influence and Role of Regulatory B Cells in Organ Transplantation: The State of the Art, Prospects, and Emerging Insights [0.03%]
调节性B细胞在器官移植中的作用和影响：现状、展望及新兴观点
Marina Fernández-González,Santiago Llorente,José Antonio Galián et al.
Marina Fernández-González et al.
B cells have attracted increasing interest in the field of organ transplantation due to their newly discovered immunoregulatory properties in alloimmune responses. Traditionally, B cells have been primarily associated with adaptive immunity...
C1q Is Recognized as a Soluble Autoantigen by Anti-C1q Antibodies of Patients with Systemic Lupus Erythematosus [0.03%]
狼疮患者抗C1q抗体识别C1q作为可溶性自身抗原
Alexandra Anatolieva Atanasova,Ginka Ilieva Cholakova,Alexandra Panagiotis Kapogianni et al.
Alexandra Anatolieva Atanasova et al.
Background and aims: C1q is an autoantigen in different autoimmune disorders, Systemic Lupus Erythematosus (SLE) and Lupus Nephritis (LN) among them. The two functional domains of C1q, the collagen-like region (CLR) and t...
N-Glycosylation of Antibodies: Biological Effects During Infections and Therapeutic Applications [0.03%]
抗体的N-连接糖基化：感染期间的生物学效应及治疗应用
Jessica Castañeda-Casimiro,Luis Vallejo-Castillo,Eliud S Peregrino et al.
Jessica Castañeda-Casimiro et al.
Antibodies are produced by cells of the adaptive immune response and recognize epitopes of microbial structures with high affinity and specificity. Antibodies are recognized by Fc fragment receptors (FcRs) found on the surface of phagocytic...
Rabbit-Derived Antithymocyte Globulin-Associated Perioperative Anaphylaxis in Renal Transplantation: A Multidisciplinary Perspective on Pathophysiology, Clinical Presentation, and Management [0.03%]
肾移植中兔源抗胸肌球蛋白相关术前过敏反应的病理生理、临床表现及处理策略：多学科视角
Imran Gani,Usman Baig,Ahmad Mirza et al.
Imran Gani et al.
Rabbit antithymocyte globulin is one of the most commonly used agents for induction immunosuppression in renal transplantation. It has contributed significantly to improved allograft survival and has a favorable safety profile. Despite its ...
Evaluating the Role of Basiliximab Induction in Simultaneous Liver-Kidney Transplantation: A Multicenter Propensity-Score-Matched Analysis [0.03%]
巴利昔单抗在肝肾联合移植中诱导作用的多中心倾向性匹配分析
Avery Koi,Trine Engebretsen,Alfred S Lea et al.
Avery Koi et al.
Introduction: Simultaneous liver-kidney (SLK) transplant recipients are considered at lower immunologic risk than kidney-alone recipients, so steroid-only induction is often used. However, some centers continue to include...