Pharmacologic Considerations in the Disposition of Antibodies and Antibody-Drug Conjugates in Preclinical Models and in Patients [0.03%]
药物动力学视角下的抗体及抗体偶联药物的临床前模型和病人处置因素考量
Andrew T Lucas,Ryan Robinson,Allison N Schorzman et al.
Andrew T Lucas et al.
The rapid advancement in the development of therapeutic proteins, including monoclonal antibodies (mAbs) and antibody-drug conjugates (ADCs), has created a novel mechanism to selectively deliver highly potent cytotoxic agents in the treatme...
Computational Prediction of the Epitopes of HA1 Protein of Influenza Viruses to its Neutralizing Antibodies [0.03%]
流感病毒HA1蛋白中和抗体表位的计算预测研究
Xiaoyan Zeng,Fiona S Legge,Chao Huang et al.
Xiaoyan Zeng et al.
In this work, we have used a new method to predict the epitopes of HA1 protein of influenza virus to several antibodies HC19, CR9114, BH151 and 4F5. While our results reproduced the binding epitopes of H3N2 or H5N1 for the neutralizing anti...
Single-Domain Antibodies and Their Formatting to Combat Viral Infections [0.03%]
单域抗体及其在对抗病毒感染中的应用格式化研究
Dorien De Vlieger,Marlies Ballegeer,Iebe Rossey et al.
Dorien De Vlieger et al.
Since their discovery in the 1990s, single-domain antibodies (VHHs), also known as Nanobodies®, have changed the landscape of affinity reagents. The outstanding solubility, stability, and specificity of VHHs, as well as their small size, e...
Therapeutic Antibody-Like Immunoconjugates against Tissue Factor with the Potential to Treat Angiogenesis-Dependent as Well as Macrophage-Associated Human Diseases [0.03%]
一种类似抗体的免疫缀合物可针对组织因子治疗血管生成依赖性和巨噬细胞相关的疾病
Zhiwei Hu
Zhiwei Hu
Accumulating evidence suggests that tissue factor (TF) is selectively expressed in pathological angiogenesis-dependent as well as macrophage-associated human diseases. Pathological angiogenesis, the formation of neovasculature, is involved ...
A Collection of Single-Domain Antibodies that Crowd Ricin Toxin's Active Site [0.03%]
一组单结构AIN抗体簇集 ricin 毒素活性位点
Siva Krishna Angalakurthi,David J Vance,Yinghui Rong et al.
Siva Krishna Angalakurthi et al.
In this report, we used hydrogen exchange-mass spectrometry (HX-MS) to identify the epitopes recognized by 21 single-domain camelid antibodies (VHHs) directed against the ribosome-inactivating subunit (RTA) of ricin toxin, a biothreat agent...
Characterization of Monoclonal Antibody-Protein Antigen Complexes Using Small-Angle Scattering and Molecular Modeling [0.03%]
基于小角散射和分子模拟的抗体抗原复合物研究
Maria Monica Castellanos,James A Snyder,Melody Lee et al.
Maria Monica Castellanos et al.
The determination of monoclonal antibody interactions with protein antigens in solution can lead to important insights guiding physical characterization and molecular engineering of therapeutic targets. We used small-angle scattering (SAS) ...
Dimerized Domain V of Beta2-Glycoprotein I Is Sufficient to Upregulate Procoagulant Activity in PMA-Treated U937 Monocytes and Require Intact Residues in Two Phospholipid-Binding Loops [0.03%]
补体β2糖蛋白Ⅰ二聚化结构域V能够上调PMA诱导的U937单核细胞促凝活性并需要两个结合磷脂环上的完整残基
Alexey Kolyada,David A Barrios,Natalia Beglova
Alexey Kolyada
Upregulation of the procoagulant activity of monocytes by antibodies to beta2- glycoprotein I (β2GPI) is one of the mechanisms contributing to thrombosis in antiphospholipid syndrome. Current knowledge about receptors responsible for the u...
Antibody Reactivity of B Cells in Lupus Patients with Increased Disease Activity and ARID3a Expression [0.03%]
ARID3a表达增加的狼疮患者疾病活动增强的B细胞抗体反应性
Julie M Ward,Judith A James,Yan D Zhao et al.
Julie M Ward et al.
Earlier studies showed that the DNA-binding protein, Bright/ARID3a bound to a subset of human and mouse immunoglobulin heavy chain promoters where it enhanced expression. Indeed, mice with transgenic expression of ARID3a in all B lymphocyte...
Current and Potential Uses of Immunocytokines as Cancer Immunotherapy [0.03%]
免疫细胞因子作为癌症免疫治疗的当前和潜在应用
Paul M Sondel,Stephen D Gillies
Paul M Sondel
Immunocytokines (ICs) are a class of molecules created by linking tumor-reactive monoclonal antibodies to cytokines that are able to activate immune cells. Tumor selective localization is provided by the ability of the mAb component to bind...