Antibodies Against SARS-CoV-2 Nucleocapsid Protein Possess Autoimmune Properties [0.03%]
抗SARS-CoV-2核衣壳蛋白的抗体具有自身免疫特性
Alexandra Rak,Yana Zabrodskaya,Pei-Fong Wong et al.
Alexandra Rak et al.
Background/objectives: Notwithstanding the declaration by the World Health Organization in May 2023 regarding the conclusion of the COVID-19 pandemic, new cases of this potentially lethal infection continue to be document...
Nanobody Therapeutics in Alzheimer's Disease: From Molecular Mechanisms to Translational Approaches [0.03%]
阿尔茨海默病的纳米抗体治疗：从分子机制到转化方法
Deepika Godugu,Kranthi Gattu,Parul Suri et al.
Deepika Godugu et al.
Nanobodies (single-domain antibodies, VHHs) have emerged as versatile tools for evaluating and treating Alzheimer's disease (AD). They offer distinct engineering benefits compared with traditional antibodies and small molecules, including s...
Enhancement of Structural Stability and IgG Affinity of a Z34C-Derived α-Helical Peptide via Lactam Stapling [0.03%]
通过内酯环亚胺连接增强Z34C衍生α-螺旋肽的结构稳定性和IgG亲和力
Jung Gu Lee,Inseo Lee,Joo-Young Kim et al.
Jung Gu Lee et al.
Background: The Fc region of immunoglobulin G (IgG) is a key target in therapeutic and analytical applications, such as antibody purification and site-specific bioconjugation. Although Protein A exhibits strong Fc-binding...
Evaluation of Three Recombinant Antigens for the Detection of Anti-Coxiella Antibodies in Cattle [0.03%]
评估三种重组抗原检测牛体内心杆菌抗体的效果
Barbara Colitti,Consiglia Longobardi,Gabriela Flores-Ramirez et al.
Barbara Colitti et al.
Background/Objectives: The detection of anti-Coxiella antibodies using serological methods is essential for identifying exposed ruminants and preventing this important zoonotic disease in livestock. In recent years, numerous attempts have b...
A Reproducible Sequence-Level Strategy to Enhance Peptide Immunogenicity While Preserving Wild-Type Epitope Recognition [0.03%]
一种可重复的序列水平策略，可在增强肽免疫原性的同时保持野生型表位识别能力
Chia-Hung Chen,Yu-Chi Chiu,Kai-Yao Huang et al.
Chia-Hung Chen et al.
Background: Short peptide epitopes are valuable for mechanistic studies, yet their intrinsic low immunogenicity and lack of commercial antibodies hinder rapid antibody generation. Methods: We developed a reproducible, sequence-level workflo...
Breakthrough for Anticancer Immunotherapy: Current Advances in Manufacturing Protocols of Chimeric Antigen Receptor-Based Therapies [0.03%]
肿瘤免疫疗法的突破：嵌合抗原受体治疗的生产流程的当前进展
Yuxin Qian,Weiwei Ma,Xiao-Ning Xu
Yuxin Qian
Chimeric antigen receptor (CAR)-based immunotherapy has emerged as a transformative strategy in anticancer treatment, driven by advances in CAR construct design, manufacturing platforms, and expansion to diverse immune cell types. The landm...
Head and Neck Dermatitis in Atopic Dermatitis: A Narrative Review of Pathogenesis, Clinical Challenges, and Therapeutic Strategies [0.03%]
特应性皮炎的头颈部皮炎：发病机制、临床挑战和治疗策略的叙述性综述
Giuseppe Lauletta,Cataldo Patruno,Claudio Brescia et al.
Giuseppe Lauletta et al.
Background: Head and neck dermatitis (HND) represents a challenging phenotype of atopic dermatitis (AD), often showing suboptimal response or paradoxical worsening during biologic therapy. Objective: To review the efficacy and safety of cur...
Comparison of Antigen Conjugation to a Peptidic Carrier or to Bovine Serum Albumin in the Serodiagnosis of Canine Visceral Leishmaniasis via Suspension Array Technology [0.03%]
通过悬浮阵列技术比较抗原与肽载体或牛血清白蛋白偶联在犬内脏利什曼病血清学诊断中的作用
Thais Stelzer Toledo,Pauline Martins Cunha,Josué da Costa Lima-Junior et al.
Thais Stelzer Toledo et al.
Backgroud/Objectives: Canine Visceral Leishmaniasis (CVL), caused by Leishmania infantum, is a significant public health concern due to dogs serving as reservoirs for human infection. An accurate and rapid diagnostic method to distinguish s...
Strategies to Screen and Evaluate Brain Targeting Antibodies Using an iPSC-Derived Blood-Brain Barrier Model [0.03%]
利用诱导多能干细胞来源的血脑屏障模型筛选和评估靶向大脑单克隆抗体的方法
Eun Seo Choi,Sophia Sahota,Emily Burnham et al.
Eun Seo Choi et al.
Background: Antibodies that cross the blood-brain barrier (BBB) by targeting receptor-mediated transport (RMT) systems can allow efficient drug delivery to the central nervous system (CNS). In order to improve brain uptak...
Recent Developments in Monoclonal-Antibody-Based Biologic Therapy for Severe Refractory Eosinophilic Asthma [0.03%]
基于单克隆抗体的生物制剂治疗重度难治性嗜酸细胞性哮喘的新进展
Garry M Walsh
Garry M Walsh
Background: Asthma exhibits marked heterogeneity both clinically and at the molecular phenotypic level, requiring specifically targeted treatments to block the key pathways of the disease. Monoclonal-antibody-based biolog...