Comparative In Vitro Evaluation of Anti-HIV Immunotoxin, Antibody-Drug Conjugate, and Radioimmunoconjugate Targeted by the Same Antibody [0.03%]
基于相同抗体的抗HIV免疫毒素、抗体偶联药物和放射性免疫缀合物在体外的对比研究
Anne-Sophie Kuhlmann,Tami Peters,Donald K Hamlin et al.
Anne-Sophie Kuhlmann et al.
Background: We are developing cytotoxic immunoconjugates (CICs) to eliminate HIV-infected cells. We investigated the efficacy and kinetics of killing by different forms of CICs targeted by the same monoclonal antibody (mA...
Jilei Wu,Chenghua Liu,Fenghao Peng et al.
Jilei Wu et al.
Background: Shiga toxin (Stx), produced by enterohemorrhagic Escherichia coli (EHEC), is a highly potent exotoxin responsible for severe complications such as hemolytic uremic syndrome (HUS). Among its isoforms, Stx2 exhibits stronger cytot...
Antibodies as Tools for Characterization, Isolation and Production Enhancement of Anti-Cancer Drugs and Steroidal Hormones from Ginsenoside and Solasodine Glycoside: A Review [0.03%]
抗体在抗肿瘤药物和甾体激素研究中的应用：综述甘草皂苷和粗毛子莲皂苷中抗肿瘤药物及皮质甾体激素的表征、分离及增效作用
Yukihiro Shoyama
Yukihiro Shoyama
There are a vast number of monoclonal antibodies (MAbs) against biological components; however, the number for natural products is less than 50. MAbs against ginsenosides, i.e., dammarane triterpene glycosides contained in ginseng, were pre...
Robustness Evaluation of a Legacy N-Glycan Profiling Method for a Therapeutic Antibody Under ICH Q14 Lifecycle Principles [0.03%]
ICH Q14生命周期原则下的抗体类药物治疗性N-糖链图谱的稳健性评估
Ming-Ching Hsieh,Chao Richard Li,Margaret A Velardo et al.
Ming-Ching Hsieh et al.
Background: This study assesses the robustness of a legacy N-glycan profiling method for the therapeutic antibody MAB1 with different Peptide-N-glycosidase F (PNGase F) enzyme sources, solid phase extraction (SPE) cartrid...
Paraneoplastic Neurological Syndromes: Advances and Future Perspectives in Immunopathogenesis and Management [0.03%]
肿瘤相关神经系统综合征：免疫病理机制及治疗策略的研究进展与未来趋势
Stoimen Dimitrov,Mihael Tsalta-Mladenov,Plamena Kabakchieva et al.
Stoimen Dimitrov et al.
Paraneoplastic neurological syndromes (PNSs) are immune-mediated disorders caused by an antitumor response that cross-reacts with the nervous system, leading to severe and often irreversible neurological disability. Once considered exceedin...
Autoantibodies as Precision Tools in Connective Tissue Diseases: From Epiphenomenon to Endophenotype [0.03%]
自身抗体在结缔组织病中的精准应用：从伴随现象到内在标志物
Muhammad Soyfoo,Julie Sarrand
Muhammad Soyfoo
Autoantibodies have long been regarded as passive reflections of immune dysregulation in connective tissue diseases (CTDs). Recent advances in systems immunology and molecular pathology have fundamentally redefined them as active molecular ...
Oral Immunotherapy-Induced Changes in IgE, IgG, and IgA: A Review of Antibody Isotype Shifts and Their Clinical Relevance in Food Allergy [0.03%]
口服免疫治疗引起的IgE、IgG和IgA的变化：对食物过敏中抗体类别转换及其临床意义的回顾
Giovanni Lasagni,Laura Vetrugno,Chiara Maria Maggiore et al.
Giovanni Lasagni et al.
Background: Food allergy is a growing public health concern, and oral immunotherapy (OIT) has emerged as a promising approach to induce desensitization and potentially sustained unresponsiveness to allergenic foods. Chang...
Bispecific Antibodies: Strategies Available to Optimize Their Safe Delivery in Patients with Multiple Myeloma [0.03%]
双特异抗体：优化多发性骨髓瘤患者安全用药的策略
Hannah Victoria Giles,Bhuvan Kishore
Hannah Victoria Giles
Bispecific antibodies (BsAbs) have emerged as an important new class drugs for the treatment of multiple myeloma (MM) over the last few years. Currently, BsAbs are only licensed for use as monotherapy in patients with relapsed/refractory MM...
Updates on Antibody Drug Conjugates and Bispecific T-Cell Engagers in SCLC [0.03%]
小细胞肺癌中的抗体偶联药物及双特异性T细胞 engager 的研究进展
Kinsley Wang,Kyle Taing,Robert Hsu
Kinsley Wang
Background/Objectives: Small-cell lung cancer (SCLC) is an aggressive neuroendocrine malignancy characterized by rapid proliferation, early metastasis, and near-universal relapse after initial therapy. While chemo-immunotherapy modestly imp...
Antibody-Based Therapeutics in Breast Cancer: Clinical and Translational Perspectives [0.03%]
乳腺癌的抗体药物：临床和转化视角
Anna Balata,Katarzyna Pogoda
Anna Balata
Breast cancer remains the most common malignancy and one of the leading causes of cancer-related death among women worldwide. Advances in antibody-based therapies have improved outcomes across all biological subtypes: HER2-positive, triple-...