Developability Evaluation of Single-Domain Antibody-Chelator Conjugates for Diagnostic Radiotracers [0.03%]
单区域抗体-螯合剂缀合物放射性药物诊断试剂的可开发性评估
Philipp D Kaiser,Simon Straß,Sandra Maier et al.
Philipp D Kaiser et al.
Background/Objectives: Developability assessment is a critical step in advancing antibody-based molecules toward clinical application. This evaluation typically begins during clinical candidate selection and continues throughout all modific...
Two Highly Specific Mouse Monoclonal Antibodies to the Putative C-Telopeptide of Human Collagen XIα1, a Cancer Biomarker [0.03%]
两种针对人XIα1胶原C-端肽的鼠源单克隆抗体及其在癌症生物标志物检测中的应用研究论文标题翻译
Marcos García-Ocaña,Lorea Legazpi-Olabide,Sandra Rodríguez-Rodero et al.
Marcos García-Ocaña et al.
Background: Collagen XIα1, encoded by the COL11A1 gene, is a minor fibrillar collagen that is overexpressed in various human cancers, in which its presence correlates with tumor aggressiveness and progression. ...
Prevalence of Viral Hepatitis Antibodies Among Alcoholics in Croatia: A Single Center's Results [0.03%]
克罗地亚酒精依赖患者病毒性肝炎感染状况及抗病毒性肝炎相关抗体的流行率
Maja Vilibić,Klara Barbić,Maja Bogdanić et al.
Maja Vilibić et al.
Background/objectives: Viral hepatitis A-E represents a significant public health problem. Data on the prevalence of viral hepatitis markers among alcoholics are inconsistent. ...
Camelid-Derived Nanobodies Targeting Human Epidermal Growth Factor Receptor: Screening, Expression, and Functional Validation [0.03%]
骆驼源针对人表皮生长因子受体纳米抗体：筛选、表达及功能验证
Yunfeng Liu,Qiting Huang,Dongna Zhang et al.
Yunfeng Liu et al.
Objectives: The epidermal growth factor receptor (EGFR) is a clinically relevant membrane receptor that is frequently overexpressed or dysregulated in multiple types of cancer, making it an important target for antibody-based strategies. Na...
Discovery of Anti-SARS-CoV-2 XBB.1.5 and JN.1 Variant-Specific Monoclonal Single-Domain Antibodies from a Synthetic Library [0.03%]
合成抗体库中发现针对XBB.1.5和JN.1变异株的单域单克隆抗体
Isamu Tsuji,Kumiko Okada,Benjamin Kroppen et al.
Isamu Tsuji et al.
Background/Objectives: The SARS-CoV-2 virus frequently undergoes mutations to evade the human immune system. Vaccines for new strains are developed each season, and an identification test confirming the specific strain is essential for vacc...
Microsecond Dynamics of Fc-CD16a Recognition: Impact of Mutations, Core Fucosylation, and Fc Asymmetry [0.03%]
微秒级Fc-CD16a识别动力学：变异、核心岩藻糖基化和Fc不对称性的影响
Sébastien Estaran,Bernard Hehlen,Alain Chavanieu
Sébastien Estaran
Background/objectives: Antibody-dependent cellular cytotoxicity relies on the interaction between the Fc region of immunoglobulin G1 (IgG1) and the CD16a receptor. While removal of core fucosylation on Fc and introduction...
Juan Carlos Silva-Espinoza,Mauricio I Rodriguez Rodriguez,Claire Eunise Perucho et al.
Juan Carlos Silva-Espinoza et al.
Background/Objectives: Schlafen (SLFN) 8 and SLFN9 are mouse members of the Schlafen protein family, believed to have arisen through a gene duplication event. The physiological roles of these proteins remain poorly defined, in part due to t...
Analytical Performance of Nanobody-Based Immunoassay and Immunosensing Platforms for Bacteria and Toxin Detection: A Systematic Review [0.03%]
基于纳米抗体的免疫分析和免疫传感平台用于细菌和毒素检测的分析性能系统评价
Aya Jalil,Nadia Touil,Omar Nyabi et al.
Aya Jalil et al.
Background: bacterial pathogens and their toxins present analytical challenges for rapid and specific detection, contributing to over 600 million cases of illness annually and worsening antimicrobial resistance (AMR). Conventional detection...
Transplacental Antibody Transfer: Mechanisms, Pregnancy-Related Disruptions, and Emerging Experimental Models [0.03%]
胎盘抗体转运：机制、妊娠相关障碍及新兴实验模型
Qiqi Li,Zhengyuan Huang,Zainab Saeed et al.
Qiqi Li et al.
The transplacental transfer of maternal immunoglobulin G from the mother to the foetus is central for providing immunity in early life, resulting in full-term newborns having IgG repertoires and levels similar to those of their mothers. The...
Antibody Avidity Profiles as Diagnostic Biomarkers in Differentiating Acute and Chronic Anisakis simplex-Related Allergic Diseases [0.03%]
用于区分由拟东方线虫引起急性期和慢性期相关过敏疾病的抗体亲和力谱型诊断生物标志物研究
Juan González-Fernández,Laura Ullate,Marta Rodero et al.
Juan González-Fernández et al.
Background/objectives: Allergic features of anisakiasis, caused by ingestion of third-stage larvae of Anisakis simplex via raw or undercooked fish, manifest clinically as acute gastroallergic anisakiasis (GAA) or chronic ...