Monoclonal Antibodies in Pregnancy of Patients with Systemic Lupus Erythematosus: Friend or Foe? A Case Report of a Patient with Multiple Pregnancies [0.03%]
抗磷脂综合征合并系统性红斑狼疮患者妊娠期单克隆抗体变化：敌或友？一例多次妊娠患者的报告
Chiara Orlandi,Angela Tincani,Micaela Fredi et al.
Chiara Orlandi et al.
Systemic lupus erythematosus (SLE) is an autoimmune disease that predominantly affects women of childbearing age, and active disease during pregnancy is associated with increased maternal and fetal morbidity. Belimumab is an effective biolo...
Julia Cieślawska,Mariola Pawlaczyk,Justyna Gornowicz-Porowska
Julia Cieślawska
Human hair performs a number of important physiological and esthetic functions. Hair loss and alopecia are complex disorders which affect people all over the world. Hair loss can be an early manifestation of various autoimmunological disord...
SARS-CoV-2 Infection and COVID-19 Vaccine Antibody Responses in Two Canadian Cohorts of Persons Living with HIV [0.03%]
HIV阳性者感染SARS-CoV-2及COVID-19疫苗抗体反应的两项加拿大队列研究
Sharon L Walmsley,Leif Erik Lovblom,Bryan Boyachuk et al.
Sharon L Walmsley et al.
Objectives: To determine the incidence and outcomes of SARS-CoV-2 infection and to evaluate seroconversion rates and quantify antibody responses to COVID-19 vaccines in two cohorts of persons living with HIV at a possible higher risk of poo...
Beata Pamuła,Martyna Banach,Marta Mikońska et al.
Beata Pamuła et al.
Background/Objectives: Antibodies are a rapidly expanding field in drug discovery, but their monospecificity limits therapeutic applications, particularly in complex inflammatory diseases. Multispecific therapeutics, which combine variable ...
Dynamics of 1,3-β-D-Glucan in Invasive Candidiasis: A Narrative Review of Microbiological Aspects and Diagnostic Implications [0.03%]
侵袭性念珠菌病中1,3-β-D-葡聚糖动力学：微生物学方面和诊断含义的叙述性综述
Maddalena Calvo,Marta Caccamo,Dalila Maria Cammarata et al.
Maddalena Calvo et al.
Invasive candidiasis (IC) remains a significant cause of morbidity and mortality among critically ill, hematologic, and neonatal patients worldwide. Rapid and accurate diagnosis is essential to guide timely antifungal therapy and improve ou...
The Effect of FcRn Binding on Ocular Disposition of Monoclonal Antibodies [0.03%]
FcRn结合对单克隆抗体眼部分布的影响
Sanika Naware,Saurav Kulkarni,Sahil Salvi et al.
Sanika Naware et al.
Background/Objectives: The neonatal Fc receptor (FcRn) plays a crucial role in extending the systemic half-life of monoclonal antibodies (mAbs), but its influence on ocular distribution remains incompletely understood. This study investigat...
The Multi-Attribute Method (MAM), An Advanced LC-MS Approach for Protein A Resin Performance and Lifecycle Evaluation [0.03%]
一种先进的LC-MS方法(MAM)用于蛋白A树脂性能及全生命周期评估
Jingming Zhang,Matthew Larsen,Timothy Blanc et al.
Jingming Zhang et al.
Background: Protein A resins are indispensable for monoclonal antibody (mAb) production, yet their condition and performance are traditionally assessed using indirect or qualitative methods. In this study, the multi-attri...
Immunogenetic Architecture of Chronic Lymphocytic Leukemia at Early Stage: Insights from the O-CLL1 Cohort [0.03%]
慢性淋巴细胞白血病早期阶段的免疫遗传学特征——来自O-CLL1队列的见解
Davide Bagnara,Andrea Nicola Mazzarello,Monica Colombo et al.
Davide Bagnara et al.
Background/objectives: The immunoglobulin heavy-chain variable (IGHV) gene repertoire represents a characteristic feature of chronic lymphocytic leukemia (CLL), although its configuration is not well defined at the early ...
Dermatomyositis with Anti-MDA5 Autoantibodies After SARS-CoV-2 mRNA Vaccination Treated with Tofacitinib: Integrating Literature Evidence and a Novel Observation [0.03%]
抗MDA5自身抗体阳性的皮肌炎患者接种新冠mRNA疫苗后的病例及托法替布治疗：结合文献证据和新观察结果
Maurizio Benucci,Elisa Cioffi,Francesca Li Gobbi et al.
Maurizio Benucci et al.
COVID-19 mRNA vaccines activate type I interferon pathways and in genetically or immunologically predisposed individuals may trigger autoimmune responses, including autoantibodies against melanoma differentiation-associated protein 5 (MDA5)...
Evaluation of Anti-dsDNA Antibodies in Laboratory Practice: Management of Different Analytical Methods and Correlation with HEp-2 Immunofluorescence Patterns [0.03%]
实验室实践中抗dsDNA抗体评估：不同分析方法的管理与HEp-2免疫荧光模式的相关性
Massimo Papale,Carmela Paolillo,Loredana Iafelice et al.
Massimo Papale et al.
Background: Anti-double-stranded DNA (anti-dsDNA) antibodies are a key serological marker for systemic lupus erythematosus (SLE) and are commonly assessed in conjunction with anti-nuclear antibody (ANA) testing by indirec...