Immune-Related Adverse Events of Cemiplimab Therapy in Advanced Cervical Cancer-Data from the Polish-Czech Cervical Cancer Immunotherapy Group (PCCIG-01) with a Review of the Literature [0.03%]
塞普利单抗治疗晚期宫颈癌的免疫相关不良事件——来自波兰捷克宫颈癌免疫治疗协会（PCCIG-01）的数据及文献回顾
Radosław Łupkowski,Karolina Górniak,Maja Lisik-Habib et al.
Radosław Łupkowski et al.
Background: Immunotherapy has become an integral part of systemic treatment for cervical cancer (CC). This study assessed the safety profile of cemiplimab and the association between immune-related adverse events (irAEs) ...
The Shifting Core: Antigenic Variability of the Influenza Virus Nucleoprotein Despite Evolutionary Conservation [0.03%]
变幻莫测的病毒核心蛋白：流感病毒核蛋白的抗原变异及其保守性进化研究
Alexandra Rak,Veronika Muzurova,Svetlana Donina et al.
Alexandra Rak et al.
Background: The highly mutable influenza virus causes severe annual infections worldwide and results in substantial socioeconomic losses. The spread of infection could be effectively controlled by cross-protective vaccine...
Safety and Efficacy of Mosunetuzumab: Experience in the Hospital Cardinale Giovanni Panico [0.03%]
Mosunetuzumab的安全性和有效性：汉普诺医院卡丁纳乔万尼潘科的临床经验
Giulio Turco,Donatella Tarantino,Antonietta Giuseppa Ferraro et al.
Giulio Turco et al.
Background/objective: Follicular lymphoma (FL) is one of the most common indolent B-cell non-Hodgkin lymphomas (NHL) and is characterized by recurrent relapses despite advances in therapy. Bispecific antibodies that redir...
Ca13Mab-17, a Novel Anti-Cadherin-13 Monoclonal Antibody for Versatile Applications [0.03%]
新颖的抗细胞粘附分子-13单克隆抗体CA13Mab-17用于多种应用
Kai Shimizu,Hiroyuki Suzuki,Mika K Kaneko et al.
Kai Shimizu et al.
Background/objectives: Cadherin-13 (CDH13), part of the cadherin family, is attached to the plasma membrane through glycosylphosphatidylinositol. CDH13 plays essential roles in the development of the neurological and vasc...
A Recombinant Antibody Against Human DRP1 Serine 616 Phosphorylation Enables Detection of BRAFV600E-Associated Mitochondrial Division in Cancer [0.03%]
一种重组抗体针对人类DRP1丝氨酸616磷酸化，可使BRAFV600E相关癌症线粒体分裂的检测成为可能
Shanon T Nizard,Yiyang Chen,Madhavika N Serasinghe et al.
Shanon T Nizard et al.
Background/objectives: Mitochondria are dynamic organelles that continuously undergo balanced cycles of fusion and division to maintain optimal function. Mitochondrial division is mediated by Dynamin-Related Protein 1 (DR...
Brain Delivery of Antibody-Derived Biologicals for Alzheimer's Disease: An Updated Narrative Review [0.03%]
Rachita K Sumbria,Ruben J Boado
Rachita K Sumbria
Antibodies directed against β-amyloid (Aβ) have been developed for the treatment of Alzheimer's disease (AD). However, the in vivo central efficacy is reduced by the poor penetration of antibodies across the blood-brain barrier (BBB). In ...
Post-Chemotherapy Antibody-Based Continuation and Maintenance Strategies in HER2-Positive Metastatic Breast Cancer: A Translational Narrative Review [0.03%]
HER2阳性转移性乳腺癌化疗后的抗体类维持和延续治疗策略：一种转化叙述性综述
Katarzyna Pogoda,Karolina Lewińska,Paulina Kalman et al.
Katarzyna Pogoda et al.
The treatment paradigm for HER2-positive metastatic breast cancer has evolved from continuous chemotherapy-based regimens to a model of finite chemotherapy induction followed by sustained antibody-driven disease control. The CLEOPATRA trial...
IMGT® Nomenclature of Immunoglobulins (IG) or Antibodies and T Cell Receptors (TR): A Common Language for Immunoinformatics and Artificial Intelligence (AI) [0.03%]
免疫球蛋白（IG）或抗体和T细胞受体（TR）的IMGT®命名法：免疫信息学和人工智能（AI）的通用语言
Marie-Paule Lefranc,Gérard Lefranc
Marie-Paule Lefranc
The immunoglobulins (IG) or antibodies and the T cell receptors (TR) are the antigen receptors of the adaptive immune responses (AIR) of jawed vertebrates (Gnathostomata). IMGT®, the international ImMunoGeneTics information system®, was c...
Development of a Human IgG1 Monoclonal Antibody Targeting Transferrin Receptor 1 for Antitumor Drug Delivery [0.03%]
一种针对转铁蛋白受体1的载药抗肿瘤人IgG1单克隆抗体药物的研发
Tingting Ji,Zhaoyun Zong,Ningyuan Gong et al.
Tingting Ji et al.
Background: Transferrin receptor protein 1 (TfR1) plays a central role in cellular iron uptake and is frequently overexpressed in malignant tumor cells, rendering it an attractive target for tumor-directed therapy and drug delivery. Methods...
Non-COVID-19 Vaccinations and the Induction of Autoantibodies in Pemphigus Diseases: A Review of the Speculative Issue and Our Clinical-Laboratory Experience [0.03%]
自身抗体诱导与大疱性 pemphigus 疾病：对一个推测问题的回顾及我们的临床-实验室经验
Maksymilian Markwitz,Natalia Welc,Klementyna Kępińska et al.
Maksymilian Markwitz et al.
Background: Pemphigus diseases are rare autoimmune blistering disorders mediated by pathogenic autoantibodies directed mainly against desmoglein 1 and desmoglein 3. Although most cases are considered idiopathic, external triggers that can d...