A Novel Tetravalent Bispecific Immune Cell Engager Activates Natural Killer Cells to Kill Cancer Cells without Mediating Fratricide [0.03%]
一种新型四价双特异性免疫细胞衔接器激活自然杀伤细胞选择性杀伤肿瘤细胞而不诱导 fratricide
Ge Yang,Shahryar Khoshtinat Nikkhoi,Hajar Owji et al.
Ge Yang et al.
We previously reported the structure, affinity, and anticancer activity of a bivalent bispecific natural killer cell engager (BiKE) composed of one anti-CD16a VHH and one anti-HER2 VHH fused via a linker. In this study, we explored the engi...
The Accurate Prediction of Antibody Deamidations by Combining High-Throughput Automated Peptide Mapping and Protein Language Model-Based Deep Learning [0.03%]
基于蛋白质语言模型的深度学习结合高通量自动肽图法准确预测抗体脱氨位点
Ben Niu,Benjamin Lee,Lili Wang et al.
Ben Niu et al.
Therapeutic antibodies such as monoclonal antibodies (mAbs), bispecific and multispecific antibodies are pivotal in therapeutic protein development and have transformed disease treatments across various therapeutic areas. The integrity of t...
Therapeutic Drug Monitoring of Infliximab and Adalimumab through Concentration and Anti-Drug Antibodies Assessment; Comparison of Sanquin Diagnostics and Theradiag Assays [0.03%]
英夫利昔单抗和阿达木单抗的治疗药物监测：通过浓度和药物抗体评估进行比较；Sanquin Diagnostics 和 Theradiag 套装对比
Wim H M Vroemen,Shakira S Agata,Joyce J B C van Beers et al.
Wim H M Vroemen et al.
Background: Therapeutic drug monitoring of biological Tumor Necrosis Factor (TNF)-alpha inhibitors is of critical importance. In this study, the performance of practically advantageous chemiluminescent immunoassays of The...
Long-Term Immunity against SARS-CoV-2 Wild-Type and Omicron XBB.1.5 in Indonesian Residents after Vaccination and Infection [0.03%]
印尼居民在接种疫苗和感染后的预防SARS-CoV-2野生型和奥密克戎XBB.1.5的长期免疫力
Karismananda,Ammar Abdurrahman Hasyim,Akihiko Sakamoto et al.
Karismananda et al.
In the post-pandemic era, evaluating long-term immunity against COVID-19 has become increasingly critical, particularly in light of continuous SARS-CoV-2 mutations. This study aimed to assess the long-term humoral immune response in sera co...
Functional Activity of Cytokine-Induced Killer Cells Enhanced by CAR-CD19 Modification or by Soluble Bispecific Antibody Blinatumomab [0.03%]
经CAR-CD19修饰或可溶性双特异性抗体Blinatumomab处理的细胞因子诱导的杀伤细胞的功能活性增强
Silvia Zaninelli,Silvia Panna,Sarah Tettamanti et al.
Silvia Zaninelli et al.
Strategies to increase the anti-tumor efficacy of cytokine-induced killer cells (CIKs) include genetic modification with chimeric antigen receptors (CARs) or the addition of soluble T-cell engaging bispecific antibodies (BsAbs). Here, CIKs ...
A Physiologically Based Pharmacokinetic Model Relates the Subcutaneous Bioavailability of Monoclonal Antibodies to the Saturation of FcRn-Mediated Recycling in Injection-Site-Draining Lymph Nodes [0.03%]
生理药动学模型将单克隆抗体的皮下生物利用度与注射部位引流淋巴结中FcRn介导的再循环饱和度联系起来
Felix Stader,Cong Liu,Abdallah Derbalah et al.
Felix Stader et al.
The bioavailability of a monoclonal antibody (mAb) or another therapeutic protein after subcutaneous (SC) dosing is challenging to predict from first principles, even if the impact of injection site physiology and drug properties on mAb bio...
Dynamics of IgM and IgG Antibody Response Profile against Linear B-Cell Epitopes from Exoerythrocytic (CelTOS and TRAP) and Erythrocytic (CyRPA) Phases of Plasmodium vivax: Follow-Up Study [0.03%]
针对间日疟原虫exoerythrocytic（CelTOS和TRAP）和 erythrocytic（CyRPA）阶段的线性 B 细胞表位的 IgM 和 IgG 抗体反应谱系的动态变化：随访研究
Cinthia Magalhães Rodolphi,Isabela Ferreira Soares,Ada da Silva Matos et al.
Cinthia Magalhães Rodolphi et al.
Malaria is a serious health problem worldwide affecting mainly children and socially vulnerable people. The biological particularities of P. vivax, such as the ability to generate dormant liver stages, the rapid maturation of gametocytes, a...
Novel Monoclonal Antibody Specific toward Amyloid-β Binds to a Unique Epitope within the N-Terminal Region [0.03%]
一种新型针对淀粉样蛋白β的单克隆抗体可结合于N末端区域的独特表位
Giavanna Paterno,Brenda D Moore,Brach M Bell et al.
Giavanna Paterno et al.
Amyloid-β (Aβ) deposition throughout the neuroaxis is a classical hallmark of several neurodegenerative diseases, most notably Alzheimer's disease (AD). Aβ peptides of varied length and diverse structural conformations are deposited with...
Identification of Conserved Linear Epitopes on Viral Protein 2 of Foot-and-Mouth Disease Virus Serotype O by Monoclonal Antibodies 6F4.D11.B6 and 8D6.B9.C3 [0.03%]
抗口蹄疫病毒O型VP2表位的单克隆抗体6F4.D11.B6和8D6.B9.C3的鉴定
Wantanee Tommeurd,Kanyarat Thueng-In,Sirin Theerawatanasirikul et al.
Wantanee Tommeurd et al.
Foot-and-mouth disease (FMD) is a highly infectious disease of cloven-hoofed animals with a significant economic impact. Early diagnosis and effective prevention and control could reduce the spread of the disease which could possibly minimi...
Enhanced N-Glycan Profiling of Therapeutic Monoclonal Antibodies through the Application of Upper-Hinge Middle-Up Level LC-HRMS Analysis [0.03%]
通过应用上铰链中间向上级LC-HRMS分析增强治疗性单克隆抗体的N-聚糖谱分析
Natalia Mesonzhnik,Anton Belushenko,Polina Novikova et al.
Natalia Mesonzhnik et al.
Therapeutic monoclonal antibodies (mAbs) are crucial in modern medicine due to their effectiveness in treating various diseases. However, the structural complexity of mAbs, particularly their glycosylation patterns, presents challenges for ...