Rational Design and Characterization of a Mutated Nanobody for Specific Targeting of Heparan Sulfate [0.03%]
合理设计并表征一种用于特异性靶向硫酸肝素的突变型纳米抗体
Junfang Hao,Qian Xu,Yanyan Cui et al.
Junfang Hao et al.
Background: Viral attachment mediated by host cell surface receptors is the first step in viral infection. As a key cell surface receptor, heparan sulfate (HS) mediates the attachment and entry of numerous non-enveloped v...
Characterization of Anti-Phospholipid Antibodies in Lyme Borreliosis Using In-House Developed ELISAs [0.03%]
利用实验室自建ELISA方法检测莱姆病患者的抗磷脂抗体及其特征分析
Polona Žigon,Katja Lakota,Katarina Ogrinc et al.
Polona Žigon et al.
Objectives: Borrelia burgdorferi sensu lato, a spirochete bacterium responsible for Lyme borreliosis-the most common tick-borne infection in North America and Europe-can trigger the production of antiphospholipid antibodi...
Anti-Type I Interferon Autoantibodies in COVID-19 and Systemic Lupus Erythematosus: A Comparative Review [0.03%]
COVID-19和系统性红斑狼疮中抗I型干扰素自身抗体的比较研究
Xin Rong Lim,Ryan Xuan Wei Teo,Rae Yi Xin Par et al.
Xin Rong Lim et al.
Type I interferons (IFN-I), including IFN-α, IFN-β, and IFN-ω, are central to antiviral defence and immune regulation. Autoantibodies targeting IFN-I (anti-IFN-I AAbs) have emerged as key pathogenic factors in severe coronavirus disease ...
Improving Gallbladder Cancer Outcomes with Antibody-Based Therapies and Immunological Profiling: A Literature Review [0.03%]
基于抗体的疗法和免疫学谱分析在改善胆囊癌结局中的作用：文献综述
Christian Caglevic,Mario Alex Contreras-Torrez,Felipe Reyes-Cosmelli et al.
Christian Caglevic et al.
Gallbladder cancer (GBC) is an aggressive tumor that, together with the cholangiocarcinomas, constitutes the spectrum of biliary tract cancer (BTC). These tumors are characterized by a frequently late diagnosis, marked genomic heterogeneity...
The Shifting Paradigm of Monoclonal Antibodies in COVID-19 Management: From Early Triumphs to Viral Resistance and Future Perspectives [0.03%]
新冠管理中单克隆抗体的转变范式：从早期胜利到病毒抵抗和未来展望
Francesco Ferrara,Flavia De Berardinis,Manlio Scognamiglio et al.
Francesco Ferrara et al.
Background: Monoclonal antibodies (mAbs) initially played a major role in outpatient COVID-19 management by providing rapid passive immunity and reducing progression to severe disease. However, continuous SARS-CoV-2 evolu...
From Single Cells to Silicon: Emerging Technologies Transforming Monoclonal Antibody Discovery [0.03%]
从单细胞到硅芯片：新兴技术推动抗体发现转型升级
Victoria Sherwood,Denise Harold,Richard O&#x;Kennedy et al.
Victoria Sherwood et al.
Monoclonal antibody (mAb) discovery has been transformed by advances in single-cell technologies, microfluidics, high-throughput sequencing, and computational design. Modern platforms enable the interrogation of large numbers of individual ...
Development and Validation of Cell-Based Bioassay for the Detection of Neutralizing Antibodies to Ocrelizumab in Human Serum Using Antibody-Dependent Cell-Mediated Cytotoxicity Test in a Reporter Cell Line Expressing FcγRIIIa [0.03%]
基于细胞的检测抗奥法奇尤单抗中和抗体的生物测定方法的发展及验证：使用报告基因细胞系表达FcγRIIIa的抗体依赖性细胞毒性试验
Olga Strizhakova,Grigory Poroshin,Andrei Pershin et al.
Olga Strizhakova et al.
Background/objectives: Ocrelizumab is a humanized monoclonal antibody targeting CD20, approved for the treatment of adult patients with relapsing multiple sclerosis (RMS) and primary progressive multiple sclerosis (PPMS)....
A Novel Monoclonal Antibody Targeting the A29 Protein of Monkeypox Virus and Its Application in Immunoassay [0.03%]
一种靶向猴痘病毒A29蛋白的单克隆抗体及其在免疫测定中的应用
Nan Jia,Weixiao Wang,Guangwei Zhao et al.
Nan Jia et al.
Background: The monkeypox virus (MPXV) has attracted considerable global attention due to its potential to cause widespread outbreaks, necessitating the development of rapid and accurate diagnostic methods of significant ...
Immunochemical Determination of IgE and IgG Autoantibodies in Patients with Chronic Spontaneous Urticaria: A Narrative Review [0.03%]
慢性自发性荨麻疹患者IgE和IgG自身抗体的免疫化学测定：综述型叙事回顾
Chrysoula-Evangelia Karachaliou,Evangelia Livaniou
Chrysoula-Evangelia Karachaliou
Background/Objectives: Chronic spontaneous urticaria (CSU) is characterized by almost daily wheals or angioedema lasting for more than six weeks and not attributable to a defined inducing factor. CSU reportedly affects 1-2% of the general p...
Carolyn Chiu,Muhammad Zaki Jawaid,Daniel Lee Cox
Carolyn Chiu
Background/Objectives: The unprecedented structural and binding data for antibodies to the SARS-CoV-2 virus taken together with the mutations for the spike protein allows for a broad simulation study of antibody-spike protein binding. This ...