Oral Paraneoplastic Pemphigus: A Scoping Review on Pathogenetic Mechanisms and Histo-Serological Profile [0.03%]
口腔副肿瘤性天疱疮：发病机制和临床、病理、抗胞质抗体谱系的综述性研究
Domenico De Falco,Sabrina Messina,Massimo Petruzzi
Domenico De Falco
Paraneoplastic pemphigus (PNP) is a rare autoimmune disorder associated with underlying neoplasms, predominantly Non-Hodgkin Lymphomas, affecting adults aged 45 to 70. This review analyzed 87 articles from MEDLINE/PubMed, Ovid and Scopus fo...
Enhancing Tumor Immunity with IL-12 and PD-1 Blockade: A Strategy for Inducing Robust Central Memory T Cell Responses in Resistant Cancer Model [0.03%]
利用IL-12和PD-1阻断增强肿瘤免疫：在耐药癌症模型中诱导强大的中央记忆T细胞反应的策略
Fentian Chen,Kexin Wu,Shiqi Lin et al.
Fentian Chen et al.
Background: Although immune checkpoint inhibitors (ICIs) have demonstrated efficacy in treating advanced cancers, their therapeutic success remains limited for many patients, with initial responders often experiencing resistance and relapse...
Generation, Characterization, and Preclinical Studies of a Novel NKG2A-Targeted Antibody BRY805 for Cancer Immunotherapy [0.03%]
BRY805抗体的生成、表征及癌症免疫治疗的临床前研究
Yaqiong Zhou,Yiru Wang,Jinfeng Liang et al.
Yaqiong Zhou et al.
Immuno-oncology has revolutionized cancer treatment, with NKG2A emerging as a novel target for immunotherapy. The blockade of NKG2A using the immune checkpoint inhibitor (ICI) monalizumab has been shown to enhance the responses of both NK c...
High Prevalence of aCL-IgA and aβ2GPI-IgA in Drug-Free Schizophrenia Patients: Evidence of a Potential Autoimmune Link [0.03%]
无药物治疗的 schizophrenia患者中高频率出现aCL-IgA和aβ2GPI-IgA：可能存在自身免疫机制的证据
Samar Samoud,Imen Zamali,Fatma Korbi et al.
Samar Samoud et al.
Background/objectives: Schizophrenia (SZ) is a complex psychiatric disorder with increasing evidence pointing to an autoimmune component, including the presence of antiphospholipid antibodies (aPLs). This study aims to as...
Ocular Mucous Membrane Pemphigoid Demonstrates a Distinct Autoantibody Profile from Those of Other Autoimmune Blistering Diseases: A Preliminary Study [0.03%]
角结膜粘膜类天疱疮与其它自身免疫性大疱病具有不同的自身抗体谱系：初步研究
Yingzi Liu,Lei Bao,Dharm Sodha et al.
Yingzi Liu et al.
Background: Ocular predominant mucous membrane pemphigoid (oMMP) is a severe subtype of autoimmune blistering disease (AIBD), which can result in scarring and vision loss. The diagnosis of oMMP is challenging as patients often have undetect...
Kazutaka Araki,Ryota Maeda
Kazutaka Araki
This review briefly traces the historical development of antibody research and related technologies. The path from early perceptions of immunity to the emergence of modern immunotherapy has been marked by pivotal discoveries and technologic...
Comparison of Conjugates Obtained Using DMSO and DMF as Solvents in the Production of Polyclonal Antibodies and ELISA Development: A Case Study on Bisphenol A [0.03%]
以DMSO和DMF作为连接体合成介质制备多克隆抗体及ELISA建立的比较研究：双酚A为例
Anna N Berlina,Nadezhda S Komova,Kseniya V Serebrennikova et al.
Anna N Berlina et al.
When developing immunochemical test systems, it is necessary to obtain specific antibodies. Their quality depends, among other things, on the immunogen used. When preparing hapten-protein conjugates to obtain antibodies for low-molecular-we...
Anti-MET Antibody Therapies in Non-Small-Cell Lung Cancer: Current Progress and Future Directions [0.03%]
非小细胞肺癌中抗MET抗体疗法的现状与未来方向
Kinsley Wang,Robert Hsu
Kinsley Wang
Background/Objectives: Non-small-cell lung cancer (NSCLC) remains a leading cause of cancer mortality globally, though advances in targeted therapies have improved treatment outcomes. The mesenchymal-epithelial transition (MET) gene plays a...
Limited Biomarker Potential for IgG Autoantibodies Reactive to Linear Epitopes in Systemic Lupus Erythematosus or Spondyloarthropathy [0.03%]
系统性红斑狼疮或脊柱关节病中针对线性表位的IgG自身抗体生物标志物潜能有限
S Janna Bashar,Zihao Zheng,Aisha M Mergaert et al.
S Janna Bashar et al.
Background: Autoantibodies are commonly used as biomarkers in autoimmune diseases, but there are limitations. For example, autoantibody biomarkers have poor sensitivity or specificity in systemic lupus erythematosus and d...
Ophthalmic Use of Targeted Biologics in the Management of Intraocular Diseases: Current and Emerging Therapies [0.03%]
针对眼部疾病的靶向生物制剂的临床应用：当前及新兴疗法
Yuan Zong,Miki Miyagaki,Mingming Yang et al.
Yuan Zong et al.
Background: Monoclonal antibodies (mAbs) have demonstrated substantial potential in the treatment of intraocular diseases. This review aimed to comprehensively evaluate the applications, efficacy, and safety of mAbs in th...