Some Human Anti-Glycan Antibodies Lack the Ability to Activate the Complement System [0.03%]
某些人类抗碳水化合物抗体缺乏补体系统激活能力
Nadezhda Shilova,Alexey Nokel,Alexander Lipatnikov et al.
Nadezhda Shilova et al.
Background. Naturally occurring human antibodies against glycans recognize and quickly eliminate infectious bacteria, viruses and aberrantly glycosylated neoplastic malignant cells, and they often initiate processes that involve the complem...
Integrating In Silico and In Vitro Tools for Optimized Antibody Development-Design of Therapeutic Anti-oxMIF Antibodies [0.03%]
基于计算和实验平台的治疗性抗OX40L抗体优化设计
Gregor Rossmueller,Irina Mirkina,Michael Thiele et al.
Gregor Rossmueller et al.
Background: Rigorous assessment of antibody developability is crucial for optimizing lead candidates before progressing to clinical studies. Recent advances in predictive tools for protein structures, surface properties, ...
Clinical Characteristics, Comorbidities, and Treatment in Patients with Pemphigus-A Single-Center Retrospective Study [0.03%]
pemphigus患者临床特征、合并症及治疗的单中心回顾性研究
Natalia Welc,Sandra Ważniewicz,Paweł Głuszak et al.
Natalia Welc et al.
Background/objectives: Pemphigus comprises a diverse group of disorders within the autoimmune bullous dermatoses (AIBDs) spectrum. Among these, pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are the most commonly en...
Intensity of Intrathecal Total IgG Synthesis in Multiple Sclerosis Correlates with the Degree of Pleocytosis, Diversity of Intrathecal Antiviral Antibody Specificities, and Female Sex [0.03%]
多发性硬化症中脑脊液免疫球蛋白合成的强度与细胞数、抗病毒抗体特异性的多样性以及女性性别有关
Benjamin Vlad,Marc Hilty,Stephan Neidhart et al.
Benjamin Vlad et al.
Background: The presence of intrathecal total IgG production is a hallmark of cerebrospinal fluid (CSF) characteristics in multiple sclerosis (MS). Herein, we systematically analyze how the intensity (instead of mere pres...
A High-Affinity Monoclonal Antibody Against the Pancreatic Ductal Adenocarcinoma Target, Anterior Gradient-2 (AGR2/PDIA17) [0.03%]
一种高亲和力的单克隆抗体对抗胰腺导管腺癌靶点前梯度-2（AGR2/PDIA17）
Reeder M Robinson,Leticia Reyes,Benjamin N Christopher et al.
Reeder M Robinson et al.
Background/objectives: Anterior Gradient-2 (AGR2/PDIA17) is a member of the protein disulfide isomerase (PDI) family of oxidoreductases. AGR2 is up-regulated in several solid tumors, including pancreatic ductal adenocarci...
An Improved Theileria parva Sporozoite Seroneutralization Assay for the Identification of East Coast Fever Immune Correlates [0.03%]
改进的东非锥虫孢子体免疫中和试验在识别东海岸热免疫相关物中的应用
Hannah Chege,Samuel Githigia,James Gathumbi et al.
Hannah Chege et al.
Background: Immune correlates of protection are ideal tools to predict treatment or vaccine efficacy. However, the accuracy of the immune correlate and the capability to robustly predict the outcome of a vaccine candidate...
50 Years of Antibody Numbering Schemes: A Statistical and Structural Evaluation Reveals Key Differences and Limitations [0.03%]
抗体编号方案的五十年：统计和结构评估揭示关键差异及局限性
Zirui Zhu,Katherine S Olson,Thomas J Magliery
Zirui Zhu
Background: The complementarity-determining region (CDR) of antibodies represents the most diverse region both in terms of sequence and structural characteristics, playing the most critical role in antibody recognition an...
Salivary Immunoglobulin a Alterations in Health and Disease: A Bibliometric Analysis of Diagnostic Trends from 2009 to 2024 [0.03%]
2009至2024年健康与疾病状态下唾液免疫球蛋白a变化的文献计量分析及诊断趋势研究
Jakub Jankowski,Kacper Nijakowski
Jakub Jankowski
Background/objectives: Salivary immunoglobulin A (IgA) is a mediator of local immunity and host defence. Altered IgA levels may predispose to bacterial invasion of the mucosa in the gastrointestinal tract, including the o...
Development of BCMA-Targeted Bispecific Natural Killer Cell Engagers for Multiple Myeloma Treatment [0.03%]
靶向BCMA双特异性自然杀伤细胞衔接器的开发用于治疗多发性骨髓瘤
Minchuan Zhang,Han Ping Loh,Shiyi Goh Fang et al.
Minchuan Zhang et al.
Background: B-cell maturation antigen (BCMA)-targeted T cell-redirecting immunotherapies, including Chimeric Antigen Receptor (CAR) T-cell therapy and T-cell engagers have demonstrated remarkable success in treating relap...
Increased Levels of Anti- Anisakis Antibodies During Hospital Admission in Septic Patients [0.03%]
感染性患者入院期间抗-Anisakis抗体水平升高
Juan Carlos Andreu-Ballester,Amparo Navarro,Miguel Angel Arribas et al.
Juan Carlos Andreu-Ballester et al.
Background/objectives: In a previous study, we described elevated anti-Anisakis IgG levels in septic patients in relation to disease severity. In this study, our objective was to analyze the evolution of anti-Anisakis imm...