Exploring Anticitrullinated Antibodies (ACPAs) and Serum-Derived Exosomes Cargoes [0.03%]
探索抗瓜氨酸化抗体(ACPA)和血清衍生的外泌体货物
Mohammed A Alghamdi,Sami M Bahlas,Sultan Abdulmughni Alamry et al.
Mohammed A Alghamdi et al.
Background: Autoantibodies such as rheumatoid factor (RF) and anticitrullinated protein autoantibodies (ACPAs) are useful tools for rheumatoid arthritis (RA). The presence of ACPAs against citrullinated proteins (CPs), es...
Influence of High Eimeria tenella Immunization Dosages on Total Oocyst Output and Specific Antibodies Recognition Response in Hybrid Pullets (Gallus gallus)-A Pilot Study [0.03%]
高剂量Eimeria tenella免疫对杂交母鸡(Gallus gallus)总体球虫卵囊排出量和特异性抗体识别反应的影响-初步研究
Marco A Juarez-Estrada,Guillermo Tellez-Isaias,Víctor M Petrone-Garcia et al.
Marco A Juarez-Estrada et al.
Background: Two high primary-immunization doses of a wild-type E. tenella strain were assessed in healthy pullets (5K versus 10K sporulated oocysts/bird) to understand the effects of coccidia infection. ...
In Vitro Functional Validation of an Anti-FREM2 Nanobody for Glioblastoma Cell Targeting [0.03%]
用于胶质母细胞瘤细胞靶向的抗FREM2纳米体的体外功能验证
Gloria Krapež,Neja Šamec,Alja Zottel et al.
Gloria Krapež et al.
Background/Objectives: Glioblastomas are the most common brain malignancies. Despite the implementation of multimodal therapy, patient life expectancy after diagnosis is barely 12 to 18 months. Glioblastomas are highly heterogeneous at the ...
A Strategy for Simultaneous Engineering of Interspecies Cross-Reactivity, Thermostability, and Expression of a Bispecific 5T4 x CD3 DART® Molecule for Treatment of Solid Tumors [0.03%]
用于治疗实体瘤的双特异性5T4×CD3 DART分子的种间交叉反应性、热稳定性和表达的同时工程策略
Renhua R Huang,Michael Spliedt,Tom Kaufman et al.
Renhua R Huang et al.
Background: Bispecific antibodies represent a promising class of biologics for cancer treatment. However, their dual specificity and complex structure pose challenges in the engineering process, often resulting in molecules with good functi...
Phenomenological Modeling of Antibody Response from Vaccine Strain Composition [0.03%]
疫苗株组成的抗体反应现象学模型
Victor Ovchinnikov,Martin Karplus
Victor Ovchinnikov
The elicitation of broadly neutralizing antibodies (bnAbs) is a major goal of vaccine design for highly mutable pathogens, such as influenza, HIV, and coronavirus. Although many rational vaccine design strategies for eliciting bnAbs have be...
Targeting CD44 and EpCAM with Antibody Dye Conjugates for the Photoimmunotherapy of Prostate Cancer [0.03%]
靶向CD44和EpCAM的抗体染料共轭物用于前列腺癌的光免疫治疗
Isis Wolf,Susanne Schultze-Seemann,Christian Gratzke et al.
Isis Wolf et al.
Background/objectives: Photoimmunotherapy (PIT) is an innovative approach for the targeted therapy of cancer. In PIT, photosensitizer dyes are conjugated to tumor-specific antibodies for targeted delivery into cancer cell...
How Broadly Neutralising Antibodies Are Redefining Immunity to Influenza [0.03%]
广谱中和抗体如何重新定义了对流感的免疫反应
Rebecca Steventon,Lucas Stolle,Craig Peter Thompson
Rebecca Steventon
Recent avian influenza outbreaks have heightened global concern over viral threats with the potential to significantly impact human health. Influenza is particularly alarming due to its history of causing pandemics and zoonotic reservoirs. ...
Challenges and Insights in Absolute Quantification of Recombinant Therapeutic Antibodies by Mass Spectrometry: An Introductory Review [0.03%]
基于质谱的重组治疗性抗体绝对定量研究挑战与启示——综述性介绍
Sarah Döring,Michael G Weller,Yvonne Reinders et al.
Sarah Döring et al.
This review describes mass spectrometry (MS)-based approaches for the absolute quantification of therapeutic monoclonal antibodies (mAbs), focusing on technical challenges in sample treatment and calibration. Therapeutic mAbs are crucial fo...
Rat as a Predictive Model for Human Clearance and Bioavailability of Monoclonal Antibodies [0.03%]
大鼠作为预测人单克隆抗体清除率和生物利用度的模型
Jason D Robarge,Kevin M Budge,Lucy Her et al.
Jason D Robarge et al.
Background: The prediction of human clearance (CL) and subcutaneous (SC) bioavailability is a critical aspect of monoclonal antibody (mAb) selection for clinical development. While monkeys are a well-accepted model for pr...
Autoantibodies, Oxidative Stress, and Nutritional State in Anorexia Nervosa [0.03%]
厌食症中的自身抗体、氧化应激和营养状况
Andrea Amerio,Eleonora Martino,Antonella Strangio et al.
Andrea Amerio et al.
Background/Objectives: Anorexia nervosa (AN) is a complex psychiatric disorder characterized by an extreme fear of gaining weight, leading to severe calorie restriction and weight loss. Beyond its psychiatric challenges, AN has significant ...