Monoclonal Antibodies in Light of Mpox Outbreak: Current Research, Therapeutic Targets, and Animal Models [0.03%]
面对猴痘疫情的单克隆抗体：当前研究、治疗靶点和动物模型
Vladimir N Nikitin,Iuliia A Merkuleva,Dmitriy N Shcherbakov
Vladimir N Nikitin
The rapid rise in monkeypox virus infections among humans from 2022 to 2024 has captured the attention of the global healthcare community. In light of the lack of mandatory vaccination and limited data on next-generation vaccines for monkey...
IgE-Crosslinking-Induced Luciferase Expression Test as a Sensitive Indicator of Anisakis Allergy [0.03%]
IgE交联诱导的荧光素酶表达试验作为敏感指示剂在诊断Anisakis过敏中的应用
Haruyo Akiyama,Masashi Niwa,Chisato Kurisaka et al.
Haruyo Akiyama et al.
Background:Anisakis allergy has been increasing, and the diagnosis of it is based on specific serum IgE detection. Recently, the IgE-crosslinking-induced luciferase expression (EXiLE) test has been proposed as convenient tool for detecting ...
Mats Eriksson,Anders Larsson
Mats Eriksson
Immunoglobulin Y (IgY) is the primary antibody found in the eggs of chicken (Gallus domesticus), allowing for large-scale antibody production with high titers, making them cost-effective antibody producers. IgY serves as a valuable alternat...
Investigation of Antibody Pharmacokinetics in Male Reproductive System and Its Characterization Using a Translational PBPK Model [0.03%]
使用转化PBPK模型研究雄性生殖系统中抗体的药代动力学及其特性化
Sree Ojili,Dhaval K Shah
Sree Ojili
Objectives: To investigate the pharmacokinetics (PK) of the monoclonal antibody (mAb) in male reproductive tissues and develop a translational physiologically based pharmacokinetic (PBPK) model to characterize the PK data. Method: The PK of...
Immune Cell Engagers: Advancing Precision Immunotherapy for Cancer Treatment [0.03%]
免疫细胞衔接器：推进癌症治疗的精准免疫疗法
Hyukmin In,Minkyoung Park,Hyeonsik Lee et al.
Hyukmin In et al.
Immune cell engagers (ICEs) are an emerging class of immunotherapies designed to harness the immune system's anti-tumor potential through precise targeting and activation of immune effector cells. By engaging T cells, natural killer (NK) ce...
Assessing the Influence of Selected Permeabilization Methods on Lymphocyte Single-Cell Multi-Omics [0.03%]
评估选定的透化方法对淋巴细胞单细胞多组学的影响
Shifan Ding,Na Lu,Hassan Abolhassani
Shifan Ding
(1) Background: Single-cell multi-omics is a powerful method for the dissection and detection of complicated immunologic functions and synapses. However, most currently available technologies merge datasets of different omics from separate ...
Clinical Scaleup of Humanized AnnA1 Antibody Yielded Unexpected High Reticuloendothelial (RES) Uptake in Mice [0.03%]
人源化AnnA1抗体的临床规模放大导致小鼠网状内皮系统(RES)摄取意外升高
Lu Lucy Xu,Satyendra Kumar Singh,Chelsea Nayback et al.
Lu Lucy Xu et al.
Background/objectives: A mouse antibody directed against truncated Annexin A1 showed high tumor retention in pre-clinical cancer models and was approved by the National Cancer Institute Experimental Therapeutics (NExT) pr...
Evaluation of SARS-CoV-2 Antibody Response Between Paired Fingerprick (HemaPEN®) and Venepuncture Collected Samples in Children and Adults [0.03%]
儿童和成人指尖采血（HemaPEN®）和静脉穿刺标本间SARS-CoV-2抗体反应的评估
Nadia Mazarakis,Zheng Quan Toh,Jill Nguyen et al.
Nadia Mazarakis et al.
Serological surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies is important to monitor population COVID-19 immunity. Dried blood spots (DBS) are a valuable method for serosurveys, particularly in remote ...
Efficient Identification of Monoclonal Antibodies Against Rift Valley Fever Virus Using High-Throughput Single Lymphocyte Transcriptomics of Immunized Mice [0.03%]
利用免疫小鼠的高通量单淋巴细胞转录组学有效识别抗裂谷热病毒的单克隆抗体
Ronit Rosenfeld,Ron Alcalay,Yfat Yahalom-Ronen et al.
Ronit Rosenfeld et al.
Background: Rift Valley fever virus (RVFV) is a zoonotic virus that poses a significant threat to both livestock and human health and has caused outbreaks in endemic regions. In humans, most patients experience a febrile illness; however, i...
Purification of a Fc-Fusion Protein with [Bathophenathroline:metal] Complexes [0.03%]
含有[Bathophenathroline:金属]复合物的Fc-融合蛋白的纯化
Thisara Jayawickrama Withanage,Ron Alcalay,Olga Krichevsky et al.
Thisara Jayawickrama Withanage et al.
In this study, we assess an alternative Fc-fusion protein purification method that does not rely on chromatographic media or ligands. Recombinant human acetylcholinesterase, fused to the Fc domain of human IgG1 (henceforth, AChE-Fc), was pu...