T330M Substitution in the Sodium-Dependent Phosphate Transporter NaPi2b Abolishes the Efficacy of Monoclonal Antibodies Against MX35 Epitope [0.03%]
钠依赖性磷酸盐转运蛋白NaPi2b中的T330M替代废除了抗MX35表位单克隆抗体的疗效
Leisan F Bulatova,Vera S Skripova,Aisylu R Sagdeeva et al.
Leisan F Bulatova et al.
Background: Monoclonal antibodies against the sodium-dependent phosphate transporter NaPi2b (SLC34A2) represent a promising approach in the treatment of ovarian and lung cancer. Of particular interest is the potential cancer-specific MX35 e...
A Novel Method for Preparing Uniform Micro-Sized Dry Powder Formulations, Including Aggregation-Controlled VHH [0.03%]
一种制备均匀微米干粉制剂的新方法（包括控制聚集的VHH）
Tatsuru Moritani,Hidekazu Masaki,Ryo Yonehara et al.
Tatsuru Moritani et al.
Background: The preparation of antibodies in powder form without changing their physicochemical properties may enable their use in new drug delivery system therapies or non-refrigerated storage. The variable domain of hea...
Discovery of Antibodies Against Endemic Coronaviruses with NGS-Based Human Fab Phage Display Platform [0.03%]
基于NGS的人源Fab噬菌体展示平台发现针对地方性冠状病毒的抗体
Oscar Chi-Chien Pan,Sean Miller,Ruchin Patel et al.
Oscar Chi-Chien Pan et al.
Background: There is an unmet medical need to develop a vaccine targeting endemic coronaviruses. Antigen-specific monoclonal antibodies (mAbs) are crucial for many assays to support vaccine development. Objective: In this study, we used the...
Low Serological Agreement of Hepatitis E in Immunocompromised Cancer Patients: A Comparative Study of Three Anti-HEV Assays [0.03%]
免疫功能低下的癌症患者中的戊型肝炎的血清学特征研究：三种抗HEV检测试剂条对比研究
Isabel-Elena Haller,Mark Reinwald,Janine Kah et al.
Isabel-Elena Haller et al.
Background/objectives: Hepatitis E virus (HEV) is one of the leading causes of acute hepatitis, with immunosuppressed individuals, such as oncology patients, being particularly vulnerable to chronic infections that may pr...
Future Landscape of Anti-Claudin 18.2 Antibodies in Gastric Adenocarcinoma [0.03%]
抗Claudin 18.2抗体在胃腺癌中的未来前景分析
Wendy M Covert,Jane E Rogers
Wendy M Covert
Advanced gastric adenocarcinoma (GAC) carries a poor prognosis. Targeted therapy in GAC has traditionally been limited to anti-human epidermal growth factor receptor-2 and anti-vascular endothelial growth factor agents. Recent years have br...
Is There a Diagnostic and Prognostic Role for Anti-Nephrin Autoantibodies in Diabetic Nephropathy? [0.03%]
抗 nephrin 自身抗体在糖尿病肾病的诊断和预后中起作用吗？
Han Sean Lee,Henry H L Wu,Arvind Ponnusamy et al.
Han Sean Lee et al.
Diabetic nephropathy (DN) is one of the key causes of end-stage kidney disease worldwide, especially in developed countries. The classic pathogenic development of DN is characterized by microalbuminuria which would progress to nephrotic-ran...
Anti-ADAMTS13 Autoantibodies in Immune-Mediated Thrombotic Thrombocytopenic Purpura [0.03%]
免疫介导的血栓性血小板减少性紫癜中的抗ADAMTS13自身抗体
Michael R Snyder,Robert W Maitta
Michael R Snyder
Autoantibodies to ADAMTS13 are at the center of pathology of the immune-mediated thrombotic thrombocytopenic purpura. These autoantibodies can be either inhibitory (enzymatic function) or non-inhibitory, resulting in protein depletion. Unde...
The Use of Heterologous Antigens for Biopanning Enables the Selection of Broadly Neutralizing Nanobodies Against SARS-CoV-2 [0.03%]
使用异源抗原进行生物淘选可以筛选出针对SARS-CoV-2的广谱中和纳米抗体
Vazirbek S Aripov,Anna V Zaykovskaya,Ludmila V Mechetina et al.
Vazirbek S Aripov et al.
Background: Since the emergence of SARS-CoV-2 in the human population, the virus genome has undergone numerous mutations, enabling it to enhance transmissibility and evade acquired immunity. As a result of these mutations, most monoclonal n...
Treatment of Ebola Virus Disease: From Serotherapy to the Use of Monoclonal Antibodies [0.03%]
埃博拉病毒病的治疗：从血清疗法到单克隆抗体的应用
Dmitriy N Shcherbakov,Anastasiya A Isaeva,Egor A Mustaev
Dmitriy N Shcherbakov
Ebola virus disease (EVD) is an acute illness with a high-case fatality rate (CFR) caused by an RNA virus belonging to the Filoviridae family. Over the past 50 years, regular EVD outbreaks have been reported. The West African EVD outbreak o...
Development of Fully Human Antibodies Targeting SIRPα and PLA2G7 for Cancer Therapy [0.03%]
针对SIRPα和PLA2G7的全人源抗体的开发用于癌症治疗
Seungmin Shin,Du-San Baek,John W Mellors et al.
Seungmin Shin et al.
Background: Macrophages play an important role in eliminating diseased and damaged cells through programmed cell death. Signal regulatory protein alpha (SIRPα) is a crucial immune checkpoint primarily expressed on myeloid cells and macroph...