Purification of Human Immunoglobulin G with Bathophenanthroline-Zn2+, -Fe2+, or -Cu2+ Complexes [0.03%]
含锌、亚铁或铜的双苯并稠合硫杂茂配合物纯化人免疫球蛋白G
Thisara Jayawickrama Withanage,Ron Alcalay,Olga Krichevsky et al.
Thisara Jayawickrama Withanage et al.
Background/objectives: Pharmaceutical companies are aware of the ongoing effort to satisfy the increasing global demand for therapeutic-grade monoclonal antibodies (mAbs), an especially difficult challenge for poor and de...
Validation and Optimization of PURE Ribosome Display for Screening Synthetic Nanobody Libraries [0.03%]
用于筛选合成型纳米抗体库的PURE核糖体展示技术的验证与优化
Bingying Liu,Daiwen Yang
Bingying Liu
Background/objectives: PURE (Protein synthesis Using Recombinant Elements), an ideal system for ribosome display, has been successfully used for nanobody selection. However, its limitations in nanobody selection, especial...
A Targeted Integration-Based CHO Cell Platform for Simultaneous Antibody Display and Secretion [0.03%]
一种用于同时展示和分泌抗体的CHO细胞平台
Jessica P Z Ng,Mariati Mariati,Jiawu Bi et al.
Jessica P Z Ng et al.
Objective: We developed a targeted integration-based CHO cell platform for simultaneous antibody display and secretion, enabling a streamlined transition from antibody library screening to production without requiring the...
The Role of Monoclonal Antibodies as Therapeutics in HPV-Related Head and Neck Cancers: An Updated Review [0.03%]
人乳头瘤病毒相关头颈癌的单克隆抗体治疗作用：最新综述
Michael Zalin,Shaan Patel,Carter Coggins et al.
Michael Zalin et al.
Background/objectives: The increasing prevalence of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) has necessitated a revaluation of therapeutic strategies. HPV-driven OPSCC differs from...
Potentiating Antibody-Dependent Cellular Cytotoxicity in Triple-Negative Breast Cancer via the Humanized Anti-CD147 Antibody [0.03%]
通过人源化抗CD147抗体促进三阴性乳腺癌的抗体依赖性细胞毒性作用
Kanyarat Thongheang,Thanathat Pamonsupornwichit,Kanokporn Sornsuwan et al.
Kanyarat Thongheang et al.
Background: Triple-negative breast cancer (TNBC) is an aggressive subtype with high metastatic potential, poor prognosis, and the absence of estrogen receptors, progesterone receptors, and human epidermal growth factor re...
A Comprehensive Review About the Use of Monoclonal Antibodies in Cancer Therapy [0.03%]
抗体药物抗肿瘤研究进展的全面回顾与分析
Angel Justiz-Vaillant,Bijay Raj Pandit,Chandrashekhar Unakal et al.
Angel Justiz-Vaillant et al.
Monoclonal antibodies (mAbs) targeting various pathways in cancer therapy play crucial roles in enhancing the immune system's ability to recognise and eliminate tumour cells. These therapies are designed to either block inhibitory immune ch...
An Exceedingly Rare Case of Mechanobullous Epidermolysis Bullosa Acquisita in a Prepubertal Child: A Review of the Clinical and Laboratory Considerations [0.03%]
罕见的青春期前儿童获得性机械性大疱性表皮松解症病例报告：临床及实验室检查分析
Aleksandra Wiktoria Bratborska,Maciej Spałek,Monika Bowszyc-Dmochowska et al.
Aleksandra Wiktoria Bratborska et al.
Introduction: Epidermolysis bullosa acquisita (EBA) is a rare autoimmune disease causing subepithelial blistering due to autoantibodies against type VII collagen. While mechanobullous EBA predominantly affects adults, our...
Effect of Acute Lung Injury (ALI) Induced by Lipopolysaccharide (LPS) on the Pulmonary Pharmacokinetics of an Antibody [0.03%]
脂多糖诱导急性肺损伤对单克隆抗体肺部药代动力学的影响研究
Shweta Jogi,Dhaval K Shah
Shweta Jogi
Objective: To investigate the effect of Lipopolysaccharide (LPS)-induced acute lung injury (ALI) on the pulmonary pharmacokinetics (PK) of a systemically administered antibody in mice. ...
A Nationwide Seroprevalence Study for Measles in Individuals of Fertile Age in Romania [0.03%]
罗马尼亚生育年龄人群 measles 流行病学的全国血清流行病学调查研究
Aurora Stanescu,Simona Maria Ruta,Mihaela Leustean et al.
Aurora Stanescu et al.
Background/Objectives: Romania remains endemic for measles due to suboptimal vaccine coverage rates. During the last three epidemics, the highest incidence of measles was recorded in children younger than 1 year, who should have been partia...
Impact of Monoclonal Antibody Aggregates on Effector Function Characterization [0.03%]
单克隆抗体聚集体对效应功能表征的影响
Wendy J Walton,Shousong Jason Zhang,Joseph J Wilson et al.
Wendy J Walton et al.
Background/objectives: Monoclonal antibodies have successfully been used for a variety of indications. Many therapeutic antibodies are IgG1 and elicit effector functions as part of their mechanism of action. It is well kn...