Light Chain Isotype and Antibody-Specificity Impact on Virus Neutralization [0.03%]
轻链同种型和抗体特异性对病毒中和的影响
Lin Sun,Roman Palt,Georg Schütz et al.
Lin Sun et al.
Therapeutic antibodies with lambda light chains (λ-Abs) are underrepresented compared to kappa light chains (κ-Abs). Here, we evaluated two SARS-CoV-2-specific monoclonal antibodies (mAbs) that exhibit high (P5C3) and low (H4) antigen bin...
Regulatory T Cell in Kidney Transplant: The Future of Cell Therapy? [0.03%]
调节性T细胞在肾移植中的作用：未来细胞治疗的新方向？
Ahmad Matarneh,Meet Patel,Kinna Parikh et al.
Ahmad Matarneh et al.
The long-term use of immunosuppressive drugs following kidney transplantation increases the risk of life-threatening infections, malignancies, and, paradoxically, eventual allograft rejection. Therefore, achieving a balance between over-imm...
Humanized VHH-hFc Fusion Proteins Targeting the L-HN Fragment of Tetanus Toxin Provided Protection In Vivo [0.03%]
人源化VHH-hFc融合蛋白靶向破伤风毒素L-HN片段提供体内保护作用
Yating Li,Kexuan Cheng,Jiazheng Guo et al.
Yating Li et al.
Background: Tetanus toxin, produced by Clostridium tetani, is the second deadliest known toxin. Antibodies capable of neutralizing tetanus toxin (TeNT) are vital for preventing and treating tetanus disease. ...
Adoptive Cell Immunotherapy in Relapse/Refractory Epstein-Barr Virus-Driven Post-Transplant Lymphoproliferative Disorders [0.03%]
复发/难治性Epstein-Barr病毒驱动的移植后淋巴增殖性疾病中的过继细胞免疫治疗
Martina Canichella,Paolo de Fabritiis
Martina Canichella
Post-transplant lymphoproliferative disorders (PTLD) represent a life-threatening complication following solid organ transplantation (SOT) and allogeneic hematopoietic stem cell transplantation (allo-HSCT), particularly in patients with rel...
Three-Dimensional Modeling of Camelus dromedarius T Cell Receptor Gamma (TRG)_Delta (TRD)/CD1D Complex Reveals Different Binding Interactions Depending on the TRD CDR3 Length [0.03%]
骆驼单峰骆驼T细胞受体γ（TRG）_δ（TRD）/CD1D复合物的三维建模显示，根据TRD CDR3长度不同的结合相互作用
Salvatrice Ciccarese,Marie-Paule Lefranc,Giulia C M Perrone et al.
Salvatrice Ciccarese et al.
Background: In the adaptive immune response of the dromedary (Camelus dromedarius, Camdro), the T cell receptor (TR) repertoire of the gamma-delta (γδ) T cells is unusually diversified both by somatic hypermutation in r...
Protective Potential and Functional Role of Antibodies Against SARS-CoV-2 Nucleocapsid Protein [0.03%]
针对SARS-CoV-2核衣壳蛋白的抗体的功能作用及其保护潜力
Alexandra Rak,Ekaterina Bazhenova,Polina Prokopenko et al.
Alexandra Rak et al.
Cases of new COVID-19 infection, which manifested in 2019 and caused a global socioeconomic crisis, still continue to be registered worldwide. The high mutational activity of SARS-CoV-2 leads to the emergence of new antigenic variants of th...
IgM Antibody Detection as a Diagnostic Marker for Acute Toxoplasmosis: Current Status of Studies and Main Limitations [0.03%]
IgM抗体检测作为急性弓形虫病诊断标志物的研究现状及主要局限性
Karolina Sołowińska,Lucyna Holec-Gąsior
Karolina Sołowińska
Accurate dating of Toxoplasma gondii infection is essential for effective clinical management, particularly in pregnant women and immunocompromised individuals, where distinguishing acute from chronic infection informs treatment decisions. ...
IgG to Galactose-Alpha-1,3-Galactose: Impact of Alpha-Gal IgE Sensitization, Blood Type, and Tick Bites [0.03%]
半乳糖-α-1,3-半乳糖(IgG)：由α-Gal(IgE)致敏、血型及蜱虫叮咬的影响
Samuel M Ailsworth,Matthew MacCallum,Nathan E Richards et al.
Samuel M Ailsworth et al.
Background: Antibodies to galactose-alpha-1,3-galactose (alpha-gal), particularly the IgM and IgG isotypes, are abundant in human sera. These antibodies are known to be an important xenotransplantation barrier, but the full implications of ...
Neutralization of the Pandemic Influenza A/H1N1 Virus with Lama glama Humanized Nanobodies (VHH) [0.03%]
骆羊人源化单域抗体(VHH)中和甲型H1N1流感病毒
Zeila Yazmín Páez-Hernández,Jose Luis Stephano-Hornedo,Jose Alberto Bolaños-Prats et al.
Zeila Yazmín Páez-Hernández et al.
Background/Objetives: Nanobodies (VHH) have become an excellent tool for diagnosis, therapy, and research since VHH shows a high capability of recognizing and neutralizing antigens. VHHs are highly soluble and stable at high temperatures, a...
Generative Deep Learning Design of Single-Domain Antibodies Against Venezuelan Equine Encephalitis Virus [0.03%]
生成式深度学习设计单结构域抗委内瑞拉马脑炎病毒抗体
Jinny L Liu,Gabrielle C Bayacal,Jerome Anthony E Alvarez et al.
Jinny L Liu et al.
Background/objectives: Venezuelan equine encephalitis virus (VEEV) represents a significant biothreat with no FDA-approved vaccine currently available, highlighting the need for alternative therapeutic strategies. Single-...