Polymeric Delivery System for mRNA Therapeutics: Design Principles and Recent Advances [0.03%]
用于mRNA治疗的聚合物递送系统：设计原则和最新进展
Sidi Bao,Irene Rose Reuben,Josie Ward et al.
Sidi Bao et al.
Messenger RNA (mRNA) therapeutics are redefining treatment approaches in vaccines, cancer immunotherapy, protein replacement, and gene editing. Lipid nanoparticles have enabled early clinical successes, but they can be limited by liver-domi...
Next-Generation Sequencing and Variant Cataloguing for Screening and Diagnosis of Mucolipidoses and Other Lysosome-Related Organelle Disorders, Including Lysosomal Membrane or Transport Disorders [0.03%]
下一代测序和变异目录在黏脂贮积病及其他溶酶体相关器官疾病的筛查与诊断中的应用，包括溶酶体膜或转运疾病
Irina Vlasova-St Louis,Svetlana Khaiboullina
Irina Vlasova-St Louis
Next-generation sequencing (NGS) has transformed the diagnostic landscape for inherited metabolic diseases by enabling high-resolution detection of pathogenic variants across genetically heterogeneous lysosomal pathways. This is particularl...
The Correlation Between the Presence of BRAFV600E and TERT Promoter Mutation and the Response to Treatment with Iodine 131 in Differentiated Thyroid Cancer Patients [0.03%]
BRAFV600E和TERT启动子突变与分化型甲状腺癌患者¹³₁碘治疗反应的相关性研究
Roko Granić,Ivan Blažeković,Josipa Miš et al.
Roko Granić et al.
Objectives: The response to radioiodine therapy (RAI) in differentiated thyroid cancer (DTC) patients is one of the most important factors that determines the treatment outcome and overall prognosis. The objective of this study is to determ...
Liver Mitochondrial Transcriptomic Responses to Dietary Crude Protein and Phosphorus Deficiencies and Feed Restriction in Wethers [0.03%]
公羊肚脐中肝脏线粒体转录组对日粮粗蛋白和磷缺乏及限饲的响应
Elmer E Fernandez,David J Innes,Walter G Bottje et al.
Elmer E Fernandez et al.
Background/Objectives: Seasonal crude protein (CP) and phosphorus (P) deficiency in northern Australian pastures reduces feed intake and growth of grazing ruminants, but the hepatic mitochondrial mechanisms underlying this response remain u...
DNMT1 and MBD2/3 Modulate Population Density-Dependent Plasticity in Terminal Oocyte Development in Bean Beetle, Callosobruchus maculatus [0.03%]
豌豆象卵巢生殖细胞终末分化过程中DNMT1和MBD2/3对种群密度依赖性表观遗传可塑性的调节作用
Qianquan Chen,Yongqin Li,Yeying Wang
Qianquan Chen
Background/Objectives: The bean beetle (Callosobruchus maculatus) exhibits population density-dependent plasticity in the terminal oocyte maturation rate. DNA methyltransferase 1 (DNMT1) plays a conserved function in reproduction that is in...
NR0B1 Gene Variants as Rare Forms of Primary Adrenal Insufficiency in Children: Case Report and Narrative Review [0.03%]
NR0B1基因变异在儿童原发性肾上腺皮质功能不全中的罕见形式：病例报告和叙事综述
Ilaria Montafia,Sotirios Dimarakis,Cristina Partenope et al.
Ilaria Montafia et al.
Primary adrenal insufficiency (PAI) is a severe and potentially life-threatening condition characterised by the inability of the adrenal cortex to produce enough glucocorticoids and/or mineralocorticoids. The clinical signs of PAI are prima...
Transcriptomic and Weighted Gene Co-Expression Network Analysis Reveals Molecular Regulatory Mechanisms of Cold Stress in Rice [0.03%]
基于水稻冷胁迫的转录组和加权基因共表达网络分析揭示其分子调控机制
Bo Ma,Haoqiang Du,Kefei Tan et al.
Bo Ma et al.
Background: Cold stress is a major abiotic factor limiting rice growth and yield. Elucidating the molecular mechanisms underlying cold tolerance is therefore of great significance for variety improvement. This study focused on the cold-tole...
Genome-Wide Identification and Characterization of the MYB Transcription Factor Family in Platycodon grandiflorus and Its Potential Involvement in Flavonoid Biosynthesis Regulation [0.03%]
桔梗MYB转录因子家族的鉴定及其可能参与黄酮类生物合成调控
Yalan Feng,Yeying Wu,Siyuan Ren et al.
Yalan Feng et al.
Background: MYB transcription factors are key regulators of plant growth, development, secondary metabolism, and stress responses. However, this family has not been systematically characterized in the traditional medicinal plant Platycodon ...
Regulation of Chromatin Acetylation by Alcohol: Dependence on Sex, Brain Region, and Mode of Exposure [0.03%]
酒精对染色质乙酰化调节的影响：性别、脑区和暴露方式的作用
Kelly M Abshire,Andrey E Ryabinin,Deena M Walker
Kelly M Abshire
Both genetic and epigenetic factors influence the development and pathology of alcohol use disorder (AUD), which is further associated with changes in learning, memory, and synaptic plasticity. Histone acetylation is an epigenetic mechanism...
Copy Number Variant Detection by NIPT: Biological Constraints and the Limits of Prenatal Genomic Inference [0.03%]
无创产前筛查中拷贝数变异检出的生物学限制及产前基因组检测限度分析
Dorina Merhala,Béla Veszprémi,Réka Anna Vass
Dorina Merhala
Background: Non-invasive prenatal testing (NIPT) based on analysis of Cell-Free Fetal DNA has transformed screening for common aneuploidies and is increasingly extended to genome-wide detection of copy number variants (CN...