Genomic Diversity and Resistance Backgrounds of Enterobacteriaceae from Gulls and Coastal Environments [0.03%]
来自海鸥和沿海环境的肠杆菌科的基因组多样性及抗性背景
Vanessa Silva,Micaela Quintelas,Manuela Caniça et al.
Vanessa Silva et al.
Background/Objectives: Enterobacterales are widely distributed in animals and environmental matrices and represent important reservoirs of antimicrobial resistance within a One Health framework. Gulls are particularly relevant because of th...
Pyroptosis-Ferroptosis Crosstalk Suggests Candidate Molecular Clusters and Immune Remodeling in Peri-Implantitis [0.03%]
关于植体周围炎中铁死亡和细胞焦亡相互作用的分子簇及免疫重塑的候选机制研究
Xinda Li,Zhijia Liu,Jiaxuan Nie et al.
Xinda Li et al.
Background: Peri-implantitis is a major biological complication for the long-term stability of dental implants but its molecular heterogeneity and mechanism of programmed cell death are unknown. The present study aimed to elucidate the mole...
A Staged Whole-Blood Transcriptomic Framework Identifies a Compact Myeloid-Lymphoid Activity Score in Systemic Lupus Erythematosus [0.03%]
系统性红斑狼疮中鉴定出一组简明的髓系-淋巴组织活性评分的分阶段全血转录组框架
Chuanwei Zhang,Lijun Pang,Ziheng Zhu et al.
Chuanwei Zhang et al.
Background/objectives: Peripheral-blood transcriptomic profiling can capture molecular heterogeneity in systemic lupus erythematosus (SLE), but discovery-stage signatures often show limited transportability across cohorts...
Functional Characterization of Fad Genes from Two Chemosymbiotic Bivalves Inhabiting the Haima Cold Seep [0.03%]
采自海马冷泉的两chemosymbiotic帘蛤Fad基因的功能表征
Runlin Liu,Meixia Chen,Danli Jiang et al.
Runlin Liu et al.
Background/objectives: Chemosymbiotic bivalves play a fundamental role in deep-sea cold seep and hydrothermal vent ecosystems, where essential long-chain polyunsaturated fatty acids (LC-PUFAs) are scarce. Whether these bi...
Frequency-Domain Transformation of cfDNA End-Motif Profiles Enhances Robust Cancer Detection [0.03%]
基于cfDNA末端基序的频率域变换增强癌症检测能力
Xinwei Sheng,Xinming Du,Qianqian Shi et al.
Xinwei Sheng et al.
Background/Objectives: Cell-free DNA (cfDNA) end-motifs (EDMs) are promising fragmentomic features for noninvasive cancer detection; however, their diagnostic utility may be limited by background signals from abundant hematopoietic-derived ...
Biallelic ATG9B Variants Define a Novel Autophagy-Related Neurodevelopmental Disorder with Cerebellar Ataxia [0.03%]
ATG9B双等位基因变异定义了一种自噬相关的新神经发育障碍疾病，以小脑共济失调为特征
Seval Kılıç,Kerem Esmen,Jean-Loup Méreaux et al.
Seval Kılıç et al.
Background/objectives: Autophagy is a highly conserved eukaryotic cellular process whose dysfunction results in human pathologies including cancer and neurodegenerative disease. First identified in yeast, ATG genes are ce...
ABO and Amelogenin Determination by PCR, from Experimental Bloodstains and from Museum Specimens, Using a Non-Destructive Approach [0.03%]
一种非破坏性方法，用于实验性血痕和博物馆样本的ABO和amelogenin基因检测
Tadeusz Dobosz,Małgorzata Bonar,Anna Jonkisz et al.
Tadeusz Dobosz et al.
Background/objectives: Museum collections constitute valuable material for investigating a wide range of histological processes. This results from the historical selection of unusual and advanced disease cases by museum c...
TRAPPC9-Related Intellectual Developmental Disorder: A Systematic Review and a Novel Case of a Complex Structural Variant [0.03%]
TRAPPC9相关智力发育障碍的系统性综述及复杂结构变异的新病例分析
Marta Calvo,Giuseppe Reynolds,Maria Luca et al.
Marta Calvo et al.
Background: Autosomal recessive intellectual developmental disorder-13 (MRT13; OMIM #613192) is a rare neurodevelopmental disorder caused by pathogenic variants in TRAPPC9. Most reported variants are single-nucleotide variants (SNVs), small...
Temporal Orchestration of Krüppel-like Factors During Cardiac Remodeling Following Isoproterenol-Induced Myocardial Injury [0.03%]
异丙肾上腺素诱导的心肌损伤后心脏重塑过程中Krüppel样因子的时序调控
Michelle G Santoyo-Suárez,Juan Andrés García-Loredo,Jimena Deyanira Mares-Montemayor et al.
Michelle G Santoyo-Suárez et al.
Background: Myocardial infarction triggers a complex remodeling process involving inflammation, hypertrophy, fibrosis, and electrical adaptation, ultimately predisposing the heart to failure. Krüppel-like factors (KLFs) are transcriptional...
Establishment of a New-Generation National Reference Material System for Fragile X Syndrome Using Targeted Long-Read Sequencing [0.03%]
基于目标长读测序的脆性X染色体综合征新一代国家参考品系的建立
Mi Zhang,Wenxin Zhang,Fei Gao et al.
Mi Zhang et al.
Background: Fragile X syndrome (FXS) is the most common monogenic cause of inherited intellectual disability and is primarily caused by CGG repeat expansion in the FMR1 gene. Conventional diagnostic methods have limited p...