Integrative Analysis of Oxidative Stress and Cellular Senescence Pathways in Chronic Obstructive Pulmonary Disease [0.03%]
慢性阻塞性肺疾病中氧化应激和细胞衰老通路的整合分析
Yanina Timasheva,Gulnaz Korytina,Vitaly Markelov et al.
Yanina Timasheva et al.
Background/Objectives: Chronic obstructive pulmonary disease (COPD) is increasingly viewed as a disorder of impaired cellular adaptation to chronic stress, involving oxidative injury, mitochondrial dysfunction, and accelerated cellular sene...
PXDN, TCF4 and TSPAN7 Are Differentially Expressed in B-Cell Acute Lymphoblastic Leukaemia: An Integrative Analysis [0.03%]
整合分析发现B细胞急性淋巴细胞白血病中PXDN，TCF4和TSPAN7差异表达
Pasquale Primo,Francesco Cecere,Alessandra Cianflone et al.
Pasquale Primo et al.
Background/Objectives: Acute lymphoblastic leukaemia (ALL) is a biologically heterogeneous disease in which transcriptional dysregulation contributes to disease onset and progression. Despite survival rates exceeding 90% in high-income coun...
From Longevity Genetics to Precision Interventions: Integrating Nutrigenomics and Epigenetic Mechanisms of Ageing [0.03%]
从长寿遗传学至精准干预：整合营养基因组学和表观遗传机制抗衰老
Lorin-Manuel Pîrlog,Andreea Cătană,Adela-Diana Pitforodeschi et al.
Lorin-Manuel Pîrlog et al.
Human ageing and longevity are increasingly understood as biologically integrated and heterogeneous processes shaped by interactions among genetic susceptibility, epigenetic remodelling, and environmental modulation. This narrative review e...
Differential DNA Methylation of the Serotonin Receptor Signaling and Glutamatergic Synapse Pathways in Adult Twins Born Preterm [0.03%]
早产双胞胎成人中血清素受体信号传导和谷氨酸能突触通路的差异DNA甲基化
Carl Peter Vittrup Rasmussen,Marianne Nygaard,Morten Frost Nielsen et al.
Carl Peter Vittrup Rasmussen et al.
Background/objectives: Early-life environment may influence long-term neurodevelopment through epigenetic regulation. Serotonergic and glutamatergic pathways are central to brain development and have been implicated in DN...
A Greek Case-Control Replication Study of IKZF1 rs4132601 and CDKN2A rs3731217 in Childhood Acute Lymphoblastic Leukemia [0.03%]
IKZF1基因多态性位点rs4132601和CDKN2A基因多态性位点rs3731217在儿童急性淋巴细胞白血病的病例-对照研究
Ioannis Kyriakidis,Spyridoula D Katsarou,Maria I Zervou et al.
Ioannis Kyriakidis et al.
Background/objectives: Inherited variants in IKZF1 and CDKN2A/2B are among the most consistently reported germline susceptibility markers for childhood acute lymphoblastic leukemia (ALL). Nonetheless, effect sizes differ ...
Transthyretin Amyloidosis-From Peculiar Neuropathy to a Treatable Chronic Multisystemic Disease [0.03%]
转甲状腺素蛋白淀粉样变性病：从罕见的周围神经病变到可治疗的慢性多系统疾病
Sasha A Živković,J David Avila
Sasha A Živković
Transthyretin amyloidosis (ATTR) is a multisystemic disorder associated with extracellular accumulation of misfolded transthyretin (TTR) protein forming insoluble amyloid deposits. Depending on the TTR genotype, ATTR is classified as heredi...
A Homozygous Missense COL1A1 Variant (p.Glu684Lys) Associated with an Arthrochalasia-like Ehlers-Danlos Syndrome Phenotype: A Case Report [0.03%]
COL1A1变异(p.Glu684Lys)与类似关节松弛型埃勒斯-丹洛斯综合征表型的相关性：一例报道
Tatiana Markova,Evgeniya Melnik,Maksim Kurelev et al.
Tatiana Markova et al.
Background/objectives: Arthrochalasia Ehlers-Danlos syndrome (aEDS) is a rare connective tissue disorder characterized by severe joint hypermobility, congenital hip dislocation, skin hyperextensibility, and muscle hypoton...
Case Reports
Genes. 2026 Jun 10;17(6):679. DOI:10.3390/genes17060679 2026
The Role of 5-HT and DA Receptor Genes in Starvation-Induced Anxiety Behavior of Portunus trituberculatus [0.03%]
五价和多巴胺受体基因在中华绒螯蟹饥饿诱导焦虑行为中的作用研究
Yangyang Lv,Wei Zhai,Yuanyuan Fu et al.
Yangyang Lv et al.
Background/objectives: Intraspecific aggression and cannibalism severely reduce survival in aquaculture of the Japanese swimming crab, Portunus trituberculatus. Starvation can induce stress-related behavioral changes and ...
LANTERN 2: Association Between Gene Molecular Profile and STAS in Lung Adenocarcinoma: A Comparative Analysis in a Prospective Real-World Population [0.03%]
灯笼研究2：肺癌腺癌中基因分子分型与STAS的关联性分析：前瞻性真实世界队列中的比较研究
Carolina Sassorossi,Davide Dalfovo,Elisa De Paolis et al.
Carolina Sassorossi et al.
Introduction: Lung cancer, the leading cause of cancer-related mortality worldwide, is a heterogeneous malignancy comprising distinct histological and molecular subtypes, with non-small cell lung cancer (NSCLC) accounting for approximately ...
Observational Study
Genes. 2026 Jun 9;17(6):677. DOI:10.3390/genes17060677 2026
Post-Transcriptional Gene Regulation by MicroRNAs During Barley Malting [0.03%]
微RNA在麦芽酿造过程中对基因的转录后调控作用研究
Sarah J Whitcomb,Marcus A Vinje,Ramamurthy Mahalingam
Sarah J Whitcomb
Background/objectives: Barley malting is an agro-industrial process that produces malt, an essential ingredient for the brewing and distilling industries. Previously, tran-scriptome profiling has revealed mRNA changes dur...