Could Metabolism-Related Long Non-Coding RNAs Be More Conserved than Their Brain-Related Counterparts? [0.03%]
代谢相关长链非编码RNA比大脑相关长链非编码RNA更保守吗？
Laurent Metzinger,Valérie Metzinger-Le Meuth
Laurent Metzinger
The human genome produces a large repertoire of non-coding RNAs (ncRNAs) with important regulatory roles in development, physiology, and most of diseases. Among these, long non-coding RNAs (lncRNAs) have emerged as key modulators of gene ex...
STAG1: Bridging the Gap Between Cohesin Complex and Epigenetic Machinery [0.03%]
桥联分离酶复合物与表观遗传装置的桥梁-STAG1蛋白质
Tiziano Palazzotti,Giulia Bruna Marchetti,Rosa Maria Alfano et al.
Tiziano Palazzotti et al.
Background: The STAG1 gene has been related to a poorly known form of intellectual disability, known as Intellectual Developmental Disorder, Autosomal Dominant 47 (MRD47). Functionally, MRD47 is part of the Cohesinopathies, a small family o...
NuRepress: Inferring Transcriptional Repressors from Phased Nucleosome Architecture [0.03%]
基于相位核小体结构推断转录阻抑物NuRepress
Qianming Xiang,Binbin Lai
Qianming Xiang
Background: The systematic identification of transcriptional repressors remains challenging, as current inference frameworks are predominantly optimized for accessible chromatin, leaving regulatory signals embedded within...
Identification of a High-Yield and Low-Cadmium-Accumulating Rice Cultivar by LAMP-Based Gn1a-i Screening and Physiological Evaluation [0.03%]
基于LAMP的GN1A-i筛选并结合生理评价发掘高产低镉水稻品种
Xiyi Chen,Shangdu Zhang,Yaoxian Chin et al.
Xiyi Chen et al.
Background/objectives: With the acceleration of global industrialization and continuous population growth, the world is increasingly confronted with the dual challenges of food insecurity and cultivated land contamination...
Infantile-Onset Glutaric Acidemia Type I with Mild Hepatopathy: Clinical, Biochemical, and Molecular Characterization of an Iranian Pediatric Cohort [0.03%]
Zahra Beyzaei,Bita Geramizadeh,Seyed Mohsen Dehghani et al.
Zahra Beyzaei et al.
Background: Glutaric acidemia type 1 (GA1) is an autosomal recessive neurometabolic disorder caused by pathogenic variants in glutaryl-CoA dehydrogenase (GCDH), with variable clinical severity despite early biochemical detectability. Popula...
Genome-Wide Identification and Tissue-Specific Expression Analysis of the FtAQP Gene Family in Tartary Buckwheat (Fagopyrum tataricum) [0.03%]
鞑靼亚麻植物FTAQPs基因家族的全基因组鉴定及组织特异性表达分析
Wenxuan Chu,Zhikun Li,Ziyi Zhang et al.
Wenxuan Chu et al.
Background: Tartary buckwheat (Fagopyrum tataricum) serves as an excellent model for studying plant water adaptation mechanisms due to its exceptional drought tolerance. While aquaporins (AQPs) mediate the transmembrane t...
Maternal RFC1 Gene Polymorphisms and Neural Tube Defects: A Case-Control Study in Ethiopia [0.03%]
母体RFC1基因多态性与神经管缺陷的病例对照研究(埃塞俄比亚)
Hasset Tamirat Molla,Dawd Gashu,Barbara Stoecker et al.
Hasset Tamirat Molla et al.
Background: Etiologies of neural tube defects (NTDs) are multifactorial. Genetic, epigenetic and environmental factors may contribute to their reported variation in prevalence across the globe. Ethiopia has among the high...
The Epigenetic Landscape and Exposome of Non-Melanoma Skin Cancer: Mechanisms, Biomarkers, and Therapeutic Perspectives [0.03%]
非黑色素瘤皮肤癌的表观遗传景观和暴露组：机制、生物标志物和治疗前景
Adrian Albulescu,Alina Fudulu,Iulia Virginia Constantin Iancu et al.
Adrian Albulescu et al.
Accounting for over 1.2 million new diagnoses worldwide in 2022, non-melanoma skin cancer (NMSC) represents the most common human cancer, predominantly manifesting as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). NMSC serves...
Extracellular Matrix Signalling and Injury Susceptibility: ACAN and FMOD Variants in Sports-Related Musculoskeletal Injuries [0.03%]
细胞外基质信号传导与受伤易感性：软骨素和角形膜蛋白多糖变体在运动相关的肌肉骨骼损伤中的作用
Agata Rzeszutko-Bełzowska,Agata Leońska-Duniec
Agata Rzeszutko-Bełzowska
Background/Objectives: Musculoskeletal soft-tissue injuries are common among physically active individuals and arise from complex interactions between environmental and biological factors. Genetic variation in genes involved in extracellula...
Toxoplasma gondii GRA12 Inhibits the NF-ΚB Signaling Pathway by Targeting P65 and the IKK Complex [0.03%]
托拉杜里亚吉恩第氏种GRA12通过靶向P65和IKK复合物抑制NF-κB信号通路
Meiling Ou,Xiaowen Fang,Ying Yuan et al.
Meiling Ou et al.
Background: The NF-κB signaling pathway plays a critical role in innate immune defense against infections. However, many pathogens secrete toxins or effectors into host cells to manipulate cellular functions for their su...