Integrating Transcriptomics, Network Pharmacology, and Machine Learning to Reveal Transglutaminase 2 (TGM2) as a Key Target Mediating Taurocholate Efficacy in Colitis [0.03%]
整合转录组学、网络药理学和机器学习，揭示转谷胺酰胺酶2（TGM2）是介导胆酸治疗结肠炎的关键靶点
Junhong Zhu,Huijin Jia,Lanlan Yi et al.
Junhong Zhu et al.
Background: Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with a rising global incidence. Natural conjugated taurocholic acid (TCA) possesses anti-inflammatory properties and shows potential thera...
Genome-Wide Association Study for Body Conformation Traits in Kazakh Fat-Tailed Coarse-Wool Sheep [0.03%]
哈萨克肥尾粗毛羊体型外貌性状的全基因组关联分析
Zhanerke Akhatayeva,Kairat Dossybayev,Altynay Kozhakhmet et al.
Zhanerke Akhatayeva et al.
Background: In Kazakhstan, there is a notable demand for fat-tail sheep breeds in both domestic and international markets, which has led to the prioritization of certain breeds for breeding purposes. Among the various she...
Minigene Splice Assays Allow Pathogenicity Reclassification of RPE65 Variants of Uncertain Significance [0.03%]
小型基因剪接试验可对RPE65意义不明变异的致病性进行再分类
Daan M Panneman,Erica G M Boonen,Zelia Corradi et al.
Daan M Panneman et al.
Background/objectives: Obtaining a genetic diagnosis for patients with inherited retinal diseases has become even more important since gene-specific therapies have become available. When genetic screening reveals variants...
Cloning and Characterization of 12 TCP Genes in Medicinal Plant Plantago asiatica via De Novo Transcriptome Assembly [0.03%]
一枝黄花（Plantago Asiatica）中TCP基因的de novo转录组测序及克隆与鉴定
Xingbin Lv,Ling Zhang,Yufang Hu et al.
Xingbin Lv et al.
Background:Plantago asiatica (P. asiatica) is an important Chinese traditional medicinal plant of the family Plantaginaceae and widely used in pharmaceutical industries. TCP transcription factors play an important role in plant development,...
Exploring Copy Number Variants in a Cohort of Children Affected by ADHD: Clinical Investigation and Translational Insights [0.03%]
注意缺陷多动障碍患儿拷贝数变异的研究：临床调查与转化见解
Federica Mirabella,Valentina Finocchiaro,Mariagrazia Figura et al.
Federica Mirabella et al.
Background/Objectives: Attention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder frequently associated with other neuropsychiatric conditions, characterized by high clinical heterogeneity and a complex genetic ...
Association of Obesity-Related Genetic Variants with Android Fat Patterning and Cardiometabolic Risk in Women [0.03%]
与女性中心性肥胖体形及心血管代谢风险相关的遗传因素研究
Débora Sá,Maria Isabel Mendonça,Francisco Sousa et al.
Débora Sá et al.
Background/Objectives: The location and distribution of excess fat, rather than overall adiposity, are stronger predictors of cardiometabolic risk and are commonly assessed using the waist-to-hip ratio (WHR). Fat distribution in women has a...
Identification of Novel Gene Cluster Potentially Associated with Insecticide Resistance in Anopheles gambiae s.l [0.03%]
冈比亚疟蚊新虫害抵抗基因簇的识别
Hyacinthe Dipina Ki,Mahamadi Kientega,Sabéré O G Yemien et al.
Hyacinthe Dipina Ki et al.
Background/objectives: Despite the increasing emergence of resistance, insecticide-based tools remain the primary method for malaria vector control in Africa. To maintain the effectiveness of these interventions, continuo...
Chloroplast Genome Evolution and Codon Usage In the Medicinal Plant Pothos chinensis (Araceae) [0.03%]
三七基因组进化及密码子使用偏好分析
Hua Chen,Jisi Zhang
Hua Chen
Background/objectives: Pothos chinensis is commonly used as traditional medicine in China and India. Codon usage analysis is a good way to understand plants' evolution. However, there is no report about the codon usage bi...
Genotype-Phenotype Correlations in PRPH2 Retinopathies: A Comprehensive Analysis of 36 Patients from the Oxford Eye Hospital, UK [0.03%]
视锥营养不良患者中PRPH2基因型与表型的相关性分析：英国牛津眼科医院36名患者的全面分析
Saoud Al-Khuzaei,Mital Shah,Arun Reginald et al.
Saoud Al-Khuzaei et al.
Purpose: To investigate genotype-phenotype correlations in PRPH2-retinopathies in a cohort of 36 patients from the Oxford Eye Hospital and report on novel pathogenic variants. ...
Obesity and the Genome: Emerging Insights from Studies in 2024 and 2025 [0.03%]
肥胖与基因组：2024年和2025年研究的新见解
Lindsey G Yoo,Courtney L Bordelon,David Mendoza et al.
Lindsey G Yoo et al.
Obesity is an epidemic that currently impacts many nations. The persistence of this disease is shaped by both genetic and epigenetic factors that extend beyond calorie balance. Research in the past year has revealed that epigenetic and cell...